HUMAN BEHAVIORAL PHARMACOLOGY OF DRUG ABUSE

药物滥用的人类行为药理学

• 批准号: 2115861
• 负责人: GEORGE BIGELOW
• 金额: $ 9.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2115861
• 关键词: AIDS education /prevention; HIV infections; antisocial personality; behavior modification; behavioral medicine; buprenorphine; cocaine; disease /disorder proneness /risk; drug abuse; drug abuse chemotherapy; drug abuse education; drug abuse therapy; drug addiction antagonist; high risk behavior /lifestyle; human subject; narcotic antagonists; opiate alkaloid; psychological reinforcement; psychopharmacology

The candidate and the research unit are dedicated to multi-faceted human research on the behavioral pharmacology of drug abuse. This laboratory is the site of the following NIDA-supported programs of which the candidate is director: an institutional postdoctoral research training program, a drug abuse Treatment Research Center, and a drug abuse Treatment Research Unit -- all of which focus on the human behavioral pharmacology of drug abuse. The candidate proposes to continue his directorship of these programs and to continue conducting human research on the topics listed below. General themes to be pursued in this research program include: Medications development for drug abuse treatment; Development of human experimental methods in drug abuse psychopharmacology; Development of behavioral treatment techniques; Integration of behavioral and pharmacological treatments; Assessment of individual differences among drug abusers; Assessment and reduction of HIV risk behavior and infection. I. Human laboratory studies of drug abuse clinical pharmacology Pharmacological modulation of cocaine effects Buprenorphine clinical pharmacology Opioid drug discrimination Opioid mixed agonist-antagonist clinical pharmacology Acute opioid physical dependence II. Clinic studies of drug abuse and its treatment Methadone treatment clinical trials Buprenorphine treatment clinical trials Community reinforcement treatment of drug abuse Assessment and treatment of antisocial drug abusers Assessment of HIV risk behavior and risk factors

候选人和研究部门致力于多方面的人类 研究药物滥用行为药理学。 这个实验室 是以下NIDA支持的程序的网站 候选人是董事：机构的博士后研究培训 计划，药物滥用治疗研究中心和药物滥用 治疗研究单位 - 所有这些专注于人类行为 药物滥用药理学。 候选人建议继续他的 这些计划的董事职位并继续进行人类研究 在下面列出的主题上。 在此中要追求的一般主题 研究计划包括：药物滥用的药物开发 治疗;开发人类滥用药物的实验方法 心理药理学；行为治疗技术的发展； 行为和药理治疗的整合；评估 吸毒者之间的个体差异；评估和减少 艾滋病毒风险行为和感染。 I.药物滥用的人类实验室研究临床药理学 可卡因作用的药理调节 丁丙诺啡临床药理学 阿片类药物歧视 阿片类混合激动剂 - 抗逆邦抗临床药理学 急性阿片类药物依赖 ii。 药物滥用及其治疗的诊所研究 美沙酮治疗临床试验 丁丙诺啡治疗临床试验 滥用药物的社区加强治疗 评估和治疗反社会药物滥用者 评估艾滋病毒风险行为和风险因素