SENESCENCE IN THE MELANOCYTE

黑色素细胞的衰老

• 批准号: 2048392
• 负责人: ESTELA E MEDRANO
• 金额: $ 6.99万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2048392
• 关键词: age difference; artificial skin; athymic mouse; cell differentiation; cell growth regulation; cell senescence; cholera toxin; gene expression; human subject; human tissue; melanocyte; melanoma; nevus; tissue /cell culture

Melanocytes participate in the homeostasis of the epidermis. the number of melanocytes in the epidermis, eyes, hair bulbs all begin to decrease around age 40-50 in humans. This proposal will analyze the cellular and biochemical manifestations of in vitro aging of the human melanocyte as isolated cultured cells and in the context of a more physiological environment provided by the use of cultured skin substitutes.

黑素细胞参与表皮的稳态。 数字 表皮中的黑素细胞，眼睛，头发鳞茎都开始减少 人类40-50岁左右。 该建议将分析细胞和 人类黑素细胞体外衰老的生化表现为 孤立的培养细胞，在更生理的背景下 使用培养的皮肤替代品提供的环境。