BEHAVIORAL TREATMENT OF OBESITY

肥胖的行为治疗

• 批准号: 2239940
• 负责人: Thomas A. Wadden
• 金额: $ 10.76万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2239940
• 关键词: aerobic exercise; blood pressure; body composition; caloric dietary content; calorimetry; clinical trials; combination therapy; cues; diet therapy; dietary control; eating disorders; fats; female; health behavior; human subject; human therapy evaluation; interview; longitudinal human study; obesity; overeating; reducing diet; weight control; weight loss

DESCRIPTION (Adapted from the Applicant's Abstract): This is a competing continuation application for a Research Scientist Development Award that was received in July 1987. The goal of the proposed research is to improve the treatment of significantly obese women (30 percent or more overweight) by conducting two randomized trials -- one primarily of exercise and the other of diet. Both studies will assess not only changes in weight but also changes in body composition, resting metabolic rate (RMR) and eating behavior, all of which may affect long-term weight control. A third study will examine the effects of weight cycling. The specific aims of each study are: 1) To determine whether resistance/strength training will prevent reductions in fat-free mass and RMR occurring with weight loss and, thus, improve long-term weight control. A total of 128 women will be randomly assigned to four conditions: a) diet alone; b) diet plus aerobic training, c) diet plus strength training; and d) diet combined with aerobic and strength training. Subjects will be treated for 1 year and followed for a second. 2) To assess the effectiveness of portion - and calorie controlled foods in 120 women randomly assigned to three conditions: 1) a 1200 kcal/d liquid diet; 2) a 1200 kcal/d diet of conventional foods; or 3) a 1200 kcal/d mixed diet, consisting of a liquid diet combined with an evening meal of food. The study will examine the hypothesis that liquid diets are initially effective because they facilitate excellent adherence, but are associated with rapid regaining of weight because of subjects' binge eating when they resume consumption of convention foods. This study will provide the first controlled evaluation of a mixed diet that resembles a popular meal-replacement plan and that is expected to capture the benefits of liquid diets while avoiding their drawbacks. 3) To assess the adverse effects of weight loss and regain in 119 women previously treated in our clinic. The candidate wishes to test the hypothesis that weight loss followed by full weight regain is associated with: 1) an increased percentage of body fat; 2) a lower RMR; and 3) increased problem eating (i.e., binge eating). The candidate's scientific development will be facilitated by visits with colleagues who will provide expertise in: 1) strength training and the measurement of energy expenditure during activity; 2) binge eating; 3) measurement of energy expenditure using doubly labeled water; and 4) methodological issues in weight cycling. The proposed research will provide rich training experiences for two postdoctoral fellows, two psychology graduate students, and several psychiatric residents who will collaborate on the studies.

描述（改编自申请人的摘要）：这是一个竞争 继续申请研究科学家发展奖 1987年7月收到。拟议的研究的目的是改善 对肥胖妇女的治疗（超重30％或更多） 通过进行两个随机试验 - 一个主要是运动和 其他饮食。 两项研究不仅会评估体重的变化，还会评估 还会改变身体成分，静息代谢率（RMR）和进食 行为，所有这些都可能影响长期体重控制。 第三项研究 将检查体重循环的影响。 每个的具体目标 研究是：1）确定电阻/力量训练是否会 防止减轻体重减轻的无脂肪质量和RMR的减少，并且 因此，改善长期体重控制。 共有128名妇女将 随机分配到四个条件：a）单独饮食； b）饮食加氧 训练，c）饮食加力训练； d）饮食与有氧运动结合 和力量训练。 受试者将接受1年的治疗，然后遵循 一秒钟。 2）评估部分和卡路里的有效性 120名随机分配到三个条件的妇女的受控食品：1）a 1200 kcal/d液体饮食； 2）传统食品的1200 kcal/d饮食；或3） 1200 kcal/d混合饮食，由液体饮食组成 晚餐食物。 该研究将研究液体的假设 饮食最初是有效的，因为它们促进了极好的依从性， 但由于受试者的重量快速增加体重 当他们恢复会议食品消费时，暴饮暴食。 这项研究 将提供类似于混合饮食的首次受控评估 一个流行的餐饮计划，预计将捕获 液体饮食的好处，同时避免其缺点。 3）评估 体重减轻的不利影响并恢复了先前治疗的119名妇女 在我们的诊所。 候选人希望检验重量的假设 损失随后重新恢复与：1）增加 体内脂肪的百分比； 2）较低的RMR； 3）饮食增加了 （即暴饮暴食）。 候选人的科学发展将通过访问来促进 将提供专业知识的同事：1）力量培训和 活动期间能量消耗的测量； 2）暴饮暴食； 3） 使用双重标记的水测量能量消耗；和4） 体重骑自行车的方法论问题。 拟议的研究将 为两个博士后研究员提供丰富的培训经验，两个 心理学研究生和几位精神病居民 研究研究。