ZINC, B12 AND COGNITIVE DECLINE IN THE ELDERLY

锌、维生素 B12 与老年人认知能力下降

• 批准号: 2048455
• 负责人: CHRISTINE L TULLY
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2048455
• 关键词: centenarian human (100+); cognition; dietary supplements; education; female; functional ability; human old age (65+); human subject; human very old age (85+); neuropsychological tests; neuropsychology; nutrient interaction; nutrition of aging; nutrition related tag; questionnaires; vitamin B12; zinc

Decline in old age, particularly in the "failure to thrive" syndrome, has prominent neuropsychosensory components. Evidence is increasing that nutritional factors, particularly micronutrients, can influence neural function, and hence may be a modifiable component of old age cognitive decline. Zinc and vitamin B12 are two important micronutrients, essential for central nervous system function. However, they are frequently inadequate in the diet of elder (based on the current Recommended Daily Allowances). Our recent pilot study in 98 elderly retired women, age 76 to 99, indicated that those with a combination of low serum zinc and low B12 had substantially lower Mini-Mental Status Examination scores when compared to those who had only one low level. The purpose of our proposed observational study is to prospectively examine the associations between the level of zinc, vitamin B12, cognitive decline, and aging. There are 678 women, age 76 to 103, in the study. To explore these relationships further, we propose an expanded four year, prospective, observational study of 760 women, age 76 to 103. We hypothesize that in elderly women: 1) low zinc and low B12 levels will each be related to an accelerated rate of cognitive decline, 2) the combination of low zinc and low B12 levels will be related to an exaggerated rate of cognitive decline (i.e., synergism), 3) certain groups are particularly vulnerable to the effects of low zinc and low B12 (those with low education, and those, specifically, with low pre-morbid cognitive ability) and 4) those who receive zinc and B12 supplements will have a slower rate of cognitive decline than comparable women who are not receiving supplements. These hypotheses will be tested in a population of women participating in an ongoing NIA-funded study (entitled "Independent and dependent life participating in an ongoing NIA-funded study (entitled "Independent and dependent life in the elderly". To test these hypotheses the SERCA applicant, will add a nutritional component to the ongoing NIA-funded study. This nutritional component will include clinical nutritional assessments and the collection of serum samples for the determination of zinc and B12 levels. These micronutrients will then be related to cognitive and functional decline (assessed by annual assessments in the ongoing NIA-funded study).

老年人的减少，特别是“发育迟缓”综合症的减少， 突出的神经心理感觉成分。越来越多的证据表明 营养因素，特别是微量营养素，可以影响神经 功能，因此可能是老年认知的一个可修改的组成部分 衰退。锌和维生素 B12 是两种重要的微量营养素，是人体必需的 对于中枢神经系统功能。然而，他们经常 长者饮食不足（根据现行每日建议 津贴）。我们最近对 98 名 76 岁的老年退休女性进行了试点研究 至 99，表明那些同时具有低血清锌和低水平的患者 B12 的简易精神状态检查分数显着较低 与那些只有一项低水平的人相比。我们提出的目的 观察性研究是前瞻性地检查之间的关联 锌、维生素 B12 的水平、认知能力下降和衰老。有 该研究共有 678 名年龄在 76 岁至 103 岁之间的女性参与。探索这些关系 此外，我们建议扩大四年的前瞻性、观察性 对 760 名年龄在 76 岁至 103 岁之间的女性进行的研究。我们假设老年女性： 1) 低锌和低 B12 水平均与加速 认知能力下降的速度，2）低锌和低B12的组合 水平将与夸大的认知能力下降速度有关（即， 协同作用），3）某些群体特别容易受到影响 低锌和低 B12（受教育程度低的人，以及那些， 具体来说，病前认知能力低）和 4）那些 接受锌和 B12 补充剂的认知速度会减慢 与未接受补充剂的女性相比有所下降。这些 假设将在参与一项研究的女性群体中进行检验 正在进行的 NIA 资助的研究（题为“独立和依赖生活 参加一项由 NIA 资助的正在进行的研究（题为“独立和 老年人的依赖生活”。为了检验这些假设，SERCA 申请人将在 NIA 资助的正在进行的项目中添加营养成分 学习。该营养成分将包括临床营养 评估和收集血清样本以确定 锌和 B12 水平。这些微量营养素将与 认知和功能下降（通过年度评估进行评估） 正在进行的 NIA 资助的研究）。