PSYCHOTHERAPY OF SUBSTANCE USE DISORDERS

物质使用障碍的心理治疗

• 批准号: 2116284
• 负责人: KATHLEEN M. CARROLL
• 金额: $ 6.75万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2116284
• 关键词: clinical trials; cocaine; cognitive behavior therapy; combination therapy; coping; drug abuse chemotherapy; drug abuse therapy; group counseling; human subject; human therapy evaluation; longitudinal human study; naltrexone; opiate alkaloid; psychosocial rehabilitation; relapse /recurrence; urinalysis; videotape /videodisc

A Research Scientist Development award is requested to allow the candidate to pursue research on the development and evaluation of psychotherapeutic treatments for substance abuse on a full-time basis. As described in the Scientific Autobiography, through adherence to a technology model of psychotherapy research, and with emphasis on development and expansion of these rigorous methods to other investigators, the candidate's long-term goal is to improve the effectiveness of substance abuse treatment. As described in the Research Plan, during the term of support from the proposed Research Scientist Development Award, the candidate will serve as Principal Investigator on two projects designed to advance knowledge on the effectiveness of psychosocial treatments for substance use disorders: The first project, Matching and Maintenance Treatments for Cocaine Dependence, will be a randomized clinical trial with 200 ambulatory cocaine abusers which will prospectively test the hypothesis that more severely dependent cocaine abusers will have better outcome when treated with cognitive-behavioral coping skills therapy (Relapse Prevention) over a less structured, supportive approach (Interpersonal Psychotherapy). In addition, this project will evaluate the value of maintenance therapy as a strategy to improve the durability of the effects of brief psychotherapeutic approaches for cocaine abuse. Subjects who complete the initial twelve-week course of treatment and whose cocaine use has improved over pretreatment levels will be randomly assigned to either (1) maintenance treatment, consisting of continuing their study treatment (Relapse Prevention or IPT) on a less frequent basis for six months, or (2) monthly assessment only for six months. The second project, CRA and Naltrexone for Opioid Dependence, will use a dismantling strategy to evaluate whether outcomes for naltrexone treatment can be enhanced through combining it with behavioral incentives and reciprocal relationship counseling. 180 recently detoxified opioid addicts will be randomly assigned to either (1) contingency management plus significant other involvement in addition to standard naltrexone treatment, (2) contingency management in addition to standard naltrexone treatment, or (3) standard naltrexone treatment alone, consisting of thrice weekly clinic visits for naltrexone, thrice weekly supervised urine toxicology screens, and weekly group counseling.

请求一项研究科学家发展奖，以允许 候选人对开发和评估进行研究 全职滥用药物的心理治疗方法。 如科学自传中所述，通过遵守 心理治疗研究的技术模型，并重点 这些严格的方法开发和扩展到其他 调查人员，候选人的长期目标是改善 药物滥用治疗的有效性。 如研究计划中所述，期间 拟议的研究科学家发展奖，候选人将服务 作为旨在提高知识的两个项目的首席研究者 关于社会心理治疗的有效性 疾病： 第一个项目，可卡因的匹配和维护治疗 依赖性将是一项随机临床试验，有200个卧床 可卡因滥用者将前瞻性地检验以下假设 治疗后，严重依赖的可卡因滥用者将有更好的结果 认知行为应对技巧疗法（预防复发） 一种结构不足的支持方法（人际心理治疗）。 此外，该项目将评估维护治疗的价值 作为提高简短效果持久性的策略 可卡因滥用的心理治疗方法。 完成的主题 最初的十二周的治疗过程，可卡因的使用 超过预处理水平将随机分配给（1） 维护处理，包括继续学习治疗 （预防复发或IPT）六个月或 （2）每月评估仅六个月。 第二个项目是阿片类药物依赖的CRA和Naltrexone，将使用 拆卸策略来评估纳曲酮的结果是否 可以通过将其与行为激励措施结合来增强治疗 和相互关系咨询。 180最近排毒阿片类药物 吸毒者将随机分配给（1）应急管理 加上标准纳曲酮之外的其他重要参与 治疗，（2）除标准纳曲酮外，应急管理 治疗，或（3）仅标准纳曲酮治疗，由 纳曲酮的每周三次诊所就诊，每周三次监督 尿液毒理学筛查和每周小组咨询。