Highly Efficient MRI Pulse Sequences for High Resolution Physiological and Functional Brain Imaging

用于高分辨率生理和功能脑成像的高效 MRI 脉冲序列

• 批准号: 10491234
• 负责人: Alexander Beckett
• 金额: $ 159万
• 依托单位: ADVANCED MRI TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491234
• 关键词: 3-Dimensional; Acceleration; Area; Blood; Blood Vessels; Brain; Brain imaging; Cerebrovascular Circulation; Clinical Protocols; Code; Computer software; Data; Deep Brain Stimulation; Development; Diagnosis; Disease; Documentation; Drainage procedure; Echo-Planar Imaging; Environment; Evaluation; Functional Imaging; Functional Magnetic Resonance Imaging; Human; Image; Imaging Techniques; Magnetic Resonance Imaging; Measurement; Measures; Medical; Neocortex; Neurons; Neuropsychology; Noise; Patients; Performance; Physicians; Physics; Physiologic pulse; Physiological; Process; Resolution; Scientist; Signal Transduction; Site; Slice; Software Tools; Specificity; Speed; Techniques; Technology; Testing; Time; Traumatic Brain Injury; Validation; Variant; Venous; Work; analysis pipeline; arterial spin labeling; blood flow measurement; blood oxygen level dependent; brain abnormalities; cerebral blood volume; data analysis pipeline; high resolution imaging; improved; innovation; nervous system disorder; neural circuit; neuronal circuitry; neurovascular; non-invasive imaging; novel; protocol development; public repository; quality assurance; reconstruction; relating to nervous system; temporal measurement

Summary This project will develop MRI physiological imaging with higher spatial and temporal resolution, larger brain coverage, and faster accelerated pulse sequences. The physiologic images have contrasts of microvascular- weighted blood oxygen level dependent (BOLD), cerebral blood flow (CBF) and cerebral blood volume (CBV). Importantly, the techniques to be developed are largely insensitive to venous blood contributions to signal, unlike traditional BOLD echo planar imaging (EPI) sequences, and thus they are extremely useful for precision imaging of physiological markers in neurological disorders and for higher specificity in cortical layer fMRI, enabling higher granularity in human neurocircuitry imaging. Novel acceleration techniques for each pulse sequence will be incorporated to increase slice-volume coverage and improve signal to noise ratio (SNR) and point spread function (PSF) in signal localization. Sequence development and evaluations will be performed at several 3T and 7T imaging sites. We will develop a software package with advanced variants of several pulse sequences: zoomed 3D gradient-and-spin-echo (GRASE), arterial spin labeling (ASL) for CBF imaging, slice- saturation slab- inversion vascular space occupancy (SS-SI-VASO) for CBV imaging, and the novel VASO technique with “multiple acquisitions with global excitation cycling” (MAGEC)-VASO to achieve whole brain coverage. The software package will also include a modular analysis pipeline for use by neuroscientists and physicians without the need for extensive MR-physics or coding expertise. Achieving non-invasive imaging of neuronal circuits in the human brain will allow neuroscientists to study normal brain processes and allow medical scientists to study neurocircuitry changes and neurological diseases. Currently, high-resolution fMRI technology could be used to identify fMRI of neural activity at different cortical depths, but is severely limited by poorly localized signal from venous drainage in the cortex. This project innovates new, robust 3D fMRI imaging sequences that eliminate venous contamination, thus affording high fidelity mapping of fine-scale neuronal circuitry compared to current gradient echo EPI BOLD imaging.

概括 该项目将开发具有更高空间和时间分辨率、更大大脑的MRI生理成像 覆盖范围和更快的加速脉冲序列具有微血管对比。 加权血氧水平依赖性（BOLD）、脑血流量（CBF）和脑血容量（CBV）。 重要的是，要开发的技术很大程度上对静脉血对信号的贡献不敏感， 与传统的 BOLD 回波平面成像 (EPI) 序列不同，因此它们对于精确度非常有用 神经系统疾病的生理标志物成像以及皮质层功能磁共振成像的更高特异性， 为每个脉冲提供更高粒度的人体神经回路成像。 将合并序列以增加切片体积覆盖范围并提高信噪比（SNR）和 信号定位中的点扩散函数（PSF）将在序列开发和评估中进行。 我们将开发一个包含多个脉冲高级变体的软件包。 序列：缩放 3D 梯度和自旋回波 (GRASE)、用于 CBF 成像的动脉自旋标记 (ASL)、切片 用于 CBV 成像的饱和度板 - 反转血管空间占用 (SS-SI-VASO) 以及新型 VASO 通过“全局激发循环多次采集”（MAGEC）-VASO 技术实现全脑 该软件包还将包括供神经科学家使用的模块化分析流程。 医生无需具备丰富的 MR 物理学或编码专业知识即可实现非侵入性成像。 人脑中的神经元回路将使神经科学家能够研究正常的大脑过程并允许 目前，医学科学家正在研究神经回路变化和神经系统疾病。 技术可用于识别不同皮质深度神经活动的功能磁共振成像，但受到严重限制 该项目创新了新的、强大的 3D fMRI 成像。 消除静脉污染的序列，从而提供精细神经网络的高保真度映射 电路与当前梯度回波 EPI BOLD 成像的比较。