EXTENSION AND VERIFICATION OF CANCER FAMILY PEDIGREES

癌症家族谱系的延伸和验证

• 批准号: 2104776
• 负责人: MICHAEL C STEEL
• 金额: $ 2.29万
• 依托单位: UNIVERSITY OF ST. ANDREWS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2104776
• 关键词: breast neoplasms; cancer registry /resource; cancer risk; environment related neoplasm /cancer; family genetics; human subject; medical records; neoplasm /cancer epidemiology; neoplasm /cancer genetics; ovary neoplasms

The purpose of this application is to obtain support for one additional full-time medical genealogist who will be attached to the staff of the Genetics Registry of the Medical Research Council's Human Genetics Unit, Edinburgh, Scotland. The specific remit of that individual will be to extend and verify the details of family histories obtained by the principal investigator and the two co-investigators from patients attending "cancer family" clinics in Edinburgh, Glasgow, Aberdeen and Dundee. These clinics provide a comprehensive counselling and investigation service for patients with a family history of cancer (notably for women at increased risk of breast/ovarian cancer on the basis of family history). Their operation is co-ordinated and, in the setting of a uniform health service, they offer the prospect of near-complete coverage of the Scottish population. The distinctive Scottish records of Births, Marriages and Deaths, to which the MRC registry has privileged access, facilitate the construction of very large and accurate pedigrees which, in turn, are the starting point for precise estimation of risks to individual family members, for establishment of an at-risk register, for mapping of cancer genes by linkage analysis, for epidemiological studies on the interaction of genetic and environmental factors in carcinogenesis and for intervention trials in high-risk groups. These longer-term objectives lie beyond the scope of the present application but are clearly dependent upon the efficiency with which extended family trees can be constructed. Because of rapidly increasing demand for the services of "cancer family" clinics, the present resources of the MRC Genetics Registry are severely strained. An additional full-time genealogist to search the Registrar General's records to trace ancestors and collateral branches of families of patients attending these clinics will accelerate a crucial rate-limiting step for much important research.

本申请的目的是获得额外的支持 全职医学家谱学家将隶属于 医学研究委员会人类遗传学部门的遗传学注册表， 爱丁堡，苏格兰。 该人的具体职责将是 扩展和验证由 主要研究人员和患者的两个共同研究者 参加爱丁堡，格拉斯哥，阿伯丁和 邓迪。 这些诊所提供了全面的咨询和 针对癌症家族史的患者的调查服务 （尤其是针对患有乳腺/卵巢癌风险增加的女性 家族史）。 他们的操作是协调的，在环境中 在统一的卫生服务中，他们提供了几乎完整的前景 苏格兰人口的覆盖范围。 苏格兰独特的记录 MRC注册中心享有的出生，婚姻和死亡 访问，促进构建非常大而准确的血统 反过来，这是确切估计风险的起点 单个家庭成员，用于建立高危登记册 通过链接分析映射癌症基因，用于流行病学研究 关于癌变中遗传和环境因素的相互作用 以及在高危组中进行干预试验。 这些长期 目标超出了本应用的范围，但显然是 取决于扩展的家谱的效率 构造。 由于对服务的需求迅速增加 “癌症家庭”诊所，MRC遗传学的当前资源 注册表严重紧张。 额外的全职家谱学家 搜索注册官的记录以追踪祖先和抵押品 参加这些诊所的患者家族的分支将加速 许多重要研究的关键限制步骤。