Dye-free, on-demand visualization of blood flow during cerebrovascular surgery

脑血管手术期间血流的无染料、按需可视化

基本信息

批准号：
10483677
负责人：
Abhishek Rege
金额：
$ 73.03万
依托单位：
VASOPTIC MEDICAL, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10483677
关键词：
Anastomosis - action Aneurysm Angiography Animal Model Animals Arteriovenous malformation Blood Blood Circulation Blood Flow Velocity Blood Vessels Blood flow Brain Brain Aneurysms Brain region Bypass Caliber Cauterize Cerebrovascular system Clinical Clip Complex Computer software Contrast Media Data Decision Making Dyes Equipment Evaluation Excision Extravasation Feedback Goals Hemorrhage Image Imaging technology Indocyanine Green Intervention Intravenous Laser Speckle Imaging Letters Logistics Manufacturer Name Measurement Methods Microscope Monitor Moyamoya Disease Neurosurgeon Operating Rooms Operative Surgical Procedures Optics Oryctolagus cuniculus Performance Perfusion Phase Postoperative Period Procedures Public Health Rattus Readiness Reperfusion Therapy Resolution Safety Sheep Sterilization Surgeon Surgical Models System Techniques Technology Testing Time Tissue Viability Tissues Validation Variant Vascular blood supply Visual Fields Visualization anterior cerebral artery base blood flow measurement blood perfusion brain surgery cerebrovascular cerebrovascular surgery clinical imaging commercialization cranium data visualization first-in-human imaging system interest middle cerebral artery multiple datasets neurosurgery novel optical imaging post intervention preclinical imaging preservation prevent prototype revascularization surgery success usability

项目摘要

ABSTRACT Cerebrovascular surgeons performing delicate surgeries such as aneurysm clipping, arteriovenous malformation resections, or revascularization procedures could benefit if quantitative information pertaining to the blood flow status of vessels in their surgical field was made available to them. Current technologies that can monitor blood flow at high resolution either use complex dedicated equipment or rely on administration of contrast agents, both of which are disruptive to the surgical procedure and hence, undesired. Dye-based techniques like ICG video- angiography may not be used frequently and often used only for post-surgical confirmation of surgical success. We propose a novel method that can noninvasively provide real-time information about blood flow in the neurosurgeon’s field of view at the spatial scale of microvessels. This modular optical imaging system (called the CVSurgeONTM) will integrate with existing neurosurgical microscopes in operating rooms providing the neurosurgeon-user an on-demand video feed of blood flow information to assist in surgical decision-making. This complementary blood flow information will be obtained using proprietary and licensed laser speckle contrast imaging technology, and optionally presented to the neurosurgeon in his/her visual field overlaid on the region of interest. We have previously built a prototype of the system and validated its function in small and large animal models of reversible and irreversible occlusion of vessels in the brain. Our proposed Phase II project aims to adapt our technology for clinical use in neurosurgery and then conduct first-in-human studies to validate the system performance and usefulness in three important types of cerebrovascular surgeries – aneurysm clipping, cauterization of arteriovenous malformations, and cerebrovascular bypass surgery for moyamoya disease.

抽象的脑血管外科医生进行动脉瘤夹闭、动静脉畸形等精细手术如果有关血流的定量信息，切除或血运重建手术可能会受益他们可以利用当前的血液监测技术。高分辨率流动要么使用复杂的专用设备，要么依赖造影剂的管理，两者都这些都会破坏手术过程，因此不受欢迎的 ICG 视频等基于染料的技术。血管造影可能不会经常使用，通常仅用于术后确认手术成功。我们提出了一种新方法，可以无创地提供有关血液流动的实时信息这种模块化光学成像系统（称为微血管空间尺度）是神经外科医生的视野。 CVSurgeONTM）将与手术室现有的神经外科显微镜集成，提供神经外科医生使用血流信息的点播视频来协助手术决策。这种补充血流信息将使用专有和许可的激光散斑对比度获得成像技术，并可选择在覆盖该区域的视野中呈现给神经外科医生我们之前已经构建了该系统的原型，并在小型和大型动物中验证了其功能。我们提出的第二阶段项目旨在建立可逆和不可逆的大脑血管闭塞模型。将我们的技术应用于神经外科临床，然后进行首次人体研究以验证系统性能和在三种重要类型的脑血管手术中的实用性——动脉瘤夹闭术、动静脉畸形的烧灼和烟雾病的脑血管搭桥手术。