Neurophysiological reward responsiveness, stress, and depressive symptoms across the perinatal period

整个围产期的神经生理奖赏反应、压力和抑郁症状

• 批准号: 10469986
• 负责人: Samantha Pegg
• 金额: $ 4.68万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469986
• 关键词: Animals; Antidepressive Agents; Award; Biological; Child; Childbirth; Clinical; Clinical Research; Cognitive; Complex; Data; Data Collection; Development; Diagnostic; Dorsal; Electroencephalogram; Electroencephalography; Emotional; Estrogens; Event-Related Potentials; Feedback; Fellowship; Frequencies; Goals; Grant; Grooming; Hormones; Hydrocortisone; Impairment; Infant; Intervention; Interview; Knowledge; Life Stress; Link; Literature; Longitudinal Studies; Maintenance; Maternal Behavior; Measures; Mental Depression; Methods; Modeling; Mood Disorders; Mothers; Neurobiology; Neurosciences; Neurosciences Research; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Perinatal; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Prevention; Process; Progesterone; Research; Research Project Grants; Research Support; Research Training; Rewards; Risk; Risk Factors; Safety; Scientist; Second Pregnancy Trimester; Social Impacts; Statistical Methods; Stress; Stress Tests; Suicide; System; Testing; Third Pregnancy Trimester; Time; Training; Training Support; Ventral Striatum; Visit; Woman; Work; antepartum depression; barrier to care; career; depressive symptoms; experience; financial incentive; functional disability; high risk; innovation; neuroimaging; neurophysiology; offspring; perinatal period; peripartum depression; pre-doctoral; preventive intervention; prospective; relating to nervous system; research study; response; skills; social; stress symptom

PROJECT SUMMARY/ABSTRACT Perinatal depression (i.e., depression during pregnancy and following childbirth) is a prevalent and debilitating condition that is associated with significant impairments in maternal functioning and negative impacts on offspring, making the identification of targets for prevention critically needed. Neuroscience research outside of the perinatal period has shown a prospective association between reduced neural reward responsiveness and depression, but the extent to which depression further alters reward responsiveness has yet to be examined. The perinatal period presents a unique time of adaptations of the reward system which have implications for the development of depression, but neuroscience research has primarily been limited to the postpartum period due to concerns about the safety of neuroimaging during pregnancy. Stress has been shown both to reduce reward responsiveness and moderate effects of low reward responsiveness on depression, adding further complexity to pathways to depression across time. Given the added stress and unique biological changes associated with reward system adaptations, longitudinal work is needed to understand pathways through which women develop perinatal depression. As part of a larger project, this research study will use safe and temporally sensitive methods to measure neural reward responsiveness, stress, and depressive symptoms in 100 pregnant women at 20 weeks gestation, 34 weeks gestation, and 8 weeks postpartum. At each assessment, participants will complete a monetary incentive delay task while electroencephalogram is recorded in response to reward and loss feedback. Event-related potential (e.g., the reward positivity, a reliable time-domain measure of initial reward responsiveness) and time-frequency data (i.e., delta and theta activity, frequency-domain markers of sensitivity to rewards and negative outcomes, respectively) will be used to measure neurophysiological response to reward. Participants will complete self-report and interview measures of depressive symptoms and stress at each visit. Through the longitudinal collection of these data, the present research will examine longitudinal associations between reduced reward responsiveness and depression using an innovative bidirectional model to tease apart directionality of these associations across time (Specific Aim 1). This work will also test stress as a moderator of the associations between reward responsiveness and depressive symptoms across the perinatal period (Specific Aim 2). This predoctoral fellowship award will bring together a team of experts in their respective fields and allow for advanced training in life stress assessment, perinatal depression and risk, EEG time-frequency analysis, and quantitative methods. Together, the research project and training will provide the fellow the opportunity to develop necessary skills for a productive career as a clinical scientist investigating alterations in emotional and social processing and how these processes contribute to the development of mood disorders to inform intervention.

项目概要/摘要 围产期抑郁症（即怀孕期间和分娩后的抑郁症）是一种普遍存在且使人衰弱的疾病。 与孕产妇功能严重受损和对婴儿产生负面影响有关的病症 后代，因此迫切需要确定预防目标。以外的神经科学研究 围产期已显示出神经奖赏反应性降低与 抑郁症，但抑郁症进一步改变奖赏反应的程度还有待研究。 围产期是奖励系统适应的独特时期，这对 抑郁症的发展，但神经科学研究主要局限于产后时期 由于担心怀孕期间神经影像学的安全性。研究表明，压力可以减少 奖励反应和低奖励反应对抑郁症的中等影响，进一步增加 随着时间的推移，抑郁症途径的复杂性。考虑到额外的压力和独特的生物变化 与奖励系统的适应相关，需要纵向工作来了解其途径 妇女会出现围产期抑郁症。作为一个更大项目的一部分，这项研究将使用安全和 测量神经奖赏反应、压力和抑郁症状的时间敏感方法 100 名妊娠 20 周、妊娠 34 周和产后 8 周的孕妇。在每个 评估时，参与者将完成一项金钱激励延迟任务，同时脑电图 记录以响应奖励和损失反馈。与事件相关的潜力（例如奖励积极性、可靠的 初始奖励响应的时域测量）和时频数据（即 delta 和 theta 活动， 分别对奖励和负面结果敏感的频域标记）将用于 测量对奖励的神经生理反应。参与者将完成自我报告和访谈措施 每次就诊时的抑郁症状和压力。通过对这些数据的纵向收集，目前 研究将使用以下方法来检验奖励反应性降低与抑郁症之间的纵向关联 一种创新的双向模型，可以梳理这些关联随时间的方向性（具体目标 1）。这项工作还将测试压力作为奖励反应性和 整个围产期的抑郁症状（具体目标 2）。该博士前奖学金将带来 汇集各自领域的专家团队，并进行生活压力评估方面的高级培训， 围产期抑郁症和风险、脑电图时频分析和定量方法。一起，研究 项目和培训将为学员提供发展必要技能的机会，以实现富有成效的职业生涯 临床科学家研究情绪和社会处理的变化以及这些过程是如何发生的 有助于情绪障碍的发展，为干预提供信息。