MAGNETIC RESONANCE OF SPINAL CORD INJURY

脊髓损伤的磁共振

• 批准号: 2268791
• 负责人: PONNADA A NARAYANA
• 金额: $ 28.82万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2268791
• 关键词: aspartate; biological models; body movement; edema; evoked potentials; hemorrhage; histology; image processing; laboratory rat; lactates; magnetic resonance imaging; nervous system disorder diagnosis; nuclear magnetic resonance spectroscopy; spinal cord imaging /visualization; spinal cord injury

Every year in the United States 10,000 to 20,000 young adults suffer permanent disability as a result of spinal cord injury. However, a proper evaluation and characterization of spinal cord injury is hindered by lack of a non-invasive radiologic modality. In these studies we propose to critically assess the role of magnetic resonance (MR), which includes both magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) , in the non-invasive diagnosis and prognosis of spinal cord injury. The proposed studies will be performed on three types of injuries with different severity in a rodent model with histopathological profiles similar to those seen in humans. The MRI-inferred extent and location of hemorrhage, edema and residual cord tissue (based on fast spin echo volume imaging and three-dimensional image analysis) will be validated with quantitative histology performed on the same animals. The MRS-determined changes in the concentration of N-acetyl aspartate (NAA) and lactate as a result of injury to the spinal cord will be compared with those determined using standard biochemical techniques. Both these studies will be performed at seven time points following the cord injury. In addition, MR results will be compared and correlated with functional (behavioral and electrophysiological) studies performed longitudinally. These studies could provide non-invasively additional and important information for predicting neurologic outcome following spinal cord injury and help customizing treatment on an individual basis in humans.

每年在美国，有10,000至20,000名年轻人受苦 脊髓损伤导致永久性残疾。 但是， 妨碍了脊髓损伤的正确评估和表征 由于缺乏非侵入性放射学方式。 在这些研究中我们 提议批判性地评估磁共振（MR）的作用， 包括磁共振成像（MRI）和磁共振 光谱法（MRS），在非侵入性诊断和预后 脊髓损伤。 拟议的研究将在三个 啮齿动物模型中严重程度不同的伤害类型 组织病理学特征与人类相似。 这 MRI提出的范围和出血，水肿和残留绳的位置 组织（基于快速自旋回波体积成像和三维 图像分析）将通过执行的定量组织学验证 在同一动物上。 MRS确定的浓度变化 N-乙酰基天冬氨酸（NAA）和乳酸因脊柱受伤而导致乳酸 将绳索与使用标准生化确定的脐带进行比较 技术。 这两个研究将在七个时间点进行 绳索受伤。 此外，将比较MR结果，并 与功能（行为和电生理）研究相关 纵向执行。 这些研究可以无创地提供 预测神经系统结果的其他重要信息 脊髓损伤后并帮助定制治疗 人类的个人基础。