NEUROMUSCULAR CONTROL IN ACTION TREMOR

动作震颤中的神经肌肉控制

• 批准号: 2264011
• 负责人: Rodger Elble
• 金额: $ 9.39万
• 依托单位: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2264011
• 关键词: adolescence (12-20); bioperiodicity; electromyography; family genetics; human subject; longitudinal human study; nervous system disorder epidemiology; neuromuscular function; sensory feedback; stretch reflex; tremor; vibration; wrist; young adult human (21-34)

Essential tremor is the most common form of pathologic tremor, but little is known about its underlying pathophysiology. Many investigators have speculated that essential tremor emerges from pathological change in the mechanisms of physiologic tremor, but until recently, there was little support for this hypothesis. Mild essential tremor is qualitatively identical to the 8- to 12-Hz component of physiologic tremor. More advanced essential tremor exhibits a frequency of 4 to 7 Hz. Consequently, a negative logarithmic relationship exists between the amplitude and frequency of essential tremor. Based upon these observations, the progression of essential tremor probably entails a gradual reduction in its frequency. A pilot study of 18 patients supported this hypothesis, which will now be tested in a larger cohort of patients. Wrist tremor and forearm electromyograms (EMG), writing tremor and head tremor will be recorded from 100 patients in years 1, 3 and 5 of this grant. The majority of these patients will come from one or more generations of 51 families with essential tremor. Tremor amplitude and frequency will be computed by spectral analysis, and the changes in tremor amplitude and frequency, over time, will be determined. Wrist tremor and forearm EMG will also be recorded from 100 20- to 40-year-old male and female controls. Two groups of controls will be identified: those with and those without a prominent 8- to 12-Hz tremor. The prevalence of a parent with essential tremor in the two groups will be compared. In addition, the prevalence of a prominent 8- to 12-Hz tremor in this cohort of 100 controls will be compared with that in a comparable number of the patients' siblings. These studies will provide important insight into the clinical significance of a prominent 8- to of this tremor to essential tremor. Finally, the essential tremor oscillator will continue to be of essential tremor to sinusoidal and pulsatile a computer-controlled torque motor and provide further insight into the role of the in governing the clinical expression of the, as yet unidentified, neural oscillator of essential tremor.

基本震颤是病理性震颤的最常见形式，但很少 关于其潜在的病理生理学知之甚少。 许多调查人员有 猜测，基本震颤是由于病理变化而产生的 生理震颤的机制，但直到最近，几乎没有 支持这一假设。 轻度基本震颤是定性的 与生理震颤的8至12 Hz成分相同。 更多的 高级必需震颤的频率为4至7 Hz。 因此，存在负面的对数关系 本质震颤的振幅和频率。 基于这些 观察结果，基本震颤的进展可能需要 频率逐渐降低。 一项对18例患者的试点研究 支持这一假设，现在将在较大的队列中进行测试 患者。 腕部震颤和前臂肌电图（EMG），写震颤 并将在1、3和5年的100名患者中记录头部震动 这笔赠款。 这些患者中的大多数将来自一个或多个 几代人有51个基本震颤的家庭。 震颤振幅和 频率将通过光谱分析计算，以及 随着时间的推移，将确定震颤幅度和频率。 手腕 震颤和前臂EMG还将记录在100至40岁之间 男性和女性对照。 将确定两组控件： 那些没有8至12 Hz震颤的人。 这 两组中具有必要震颤的父母的患病率将是 比较的。 另外，突出的8至12 Hz震颤的流行率 将100个对照组与可比的100个对照组进行比较 患者的兄弟姐妹数量。 这些研究将提供重要的 深入了解这一点的临床意义 震颤到基本震颤。 最后，基本震颤振荡器 将继续对正弦和搏动A的必要震颤 计算机控制的扭矩电动机，并进一步了解 迄今为止的临床表达中的作用 基本震颤的身份不明的神经振荡器。