The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation

睡眠不足和失眠症对情绪调节的行为和神经标志物的影响

• 批准号: 10449844
• 负责人: Tony J Cunningham
• 金额: $ 15.26万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10449844
• 关键词: Acute; Adult; Amygdaloid structure; Anterior; Automobile Driving; Aversive Stimulus; Award; Behavioral; Biological Markers; Brain region; Chronic; Clinical; Complement; Data; Data Analyses; Data Collection; Deterioration; Development; Diagnosis; Discipline of Nursing; Emotional; Emotions; Etiology; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Grant; Hyperactivity; Impairment; Individual; Insula of Reil; K-Series Research Career Programs; Link; Medical; Mental Depression; Mental disorders; Mentorship; Methodology; Military Personnel; Mood Disorders; Moods; Neurocognitive; Occupations; Outcome; Participant; Patient Recruitments; Patients; Pattern; Play; Prefrontal Cortex; Process; Protocols documentation; Reporting; Research; Research Personnel; Rest; Risk; Risk Factors; Role; Sampling; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Symptoms; Time; Training; Translational Research; Volition; behavior test; behavioral pharmacology; behavioral response; career development; cohort; computerized data processing; coping; design; effective therapy; emotion dysregulation; emotion regulation; emotional distress; emotional functioning; emotional reaction; experience; first responder; functional MRI scan; hazard; high risk; improved; longitudinal design; mood regulation; multimodality; neural circuit; neural correlate; neural network; novel therapeutics; recruit; relating to nervous system; response; skills; sleep regulation; suicidal risk; therapeutic target; trend

PROJECT SUMMARY Healthy functioning necessitates an ability to manage our emotions. A growing body of evidence suggests that sleep plays a crucial role in this adaptive process by maintaining the neural circuitry required to optimize emotion regulation. Further, chronically disrupted sleep is a common feature and potentially an underlying cause of a number of psychiatric disorders marked by impaired mood and emotion regulation, such as depression. The consequences of this relationship become even more dire with the recognition that chronic sleep disruption more than doubles the risk of suicide. The objective of the proposed study is to determine the overlapping and differential impact of clinical insomnia in patients and multiple nights of insufficient sleep in healthy controls on behavioral and neural responses during an emotion regulation task. My central hypothesis is that clinical sleep disturbance and multiple nights of truncated sleep both disrupt the circuitry needed for successful emotion regulation, and therefore are critical drivers in the dysregulation of emotional functioning. The primary rationale is that a vast majority of our understanding of the relationship between disrupted sleep and emotion function has relied either on single-night, acute sleep deprivation or assessment of trends in large samples, leaving a major gap in understanding the mechanistic impact of longer, more chronic sleep loss on emotion regulation. This information is essential to understand the degree to which different forms of disrupted sleep account for mood and emotion dysregulation in a host of psychiatric conditions. In the proposed study, I will recruit patients with Insomnia Disorder (ID; n=25) and healthy individuals that undergo a normal sleep (n=25) or sleep restriction (n=25) protocol. All participants will complete an emotion regulation paradigm on two occasions, once as a baseline, and a second time during functional magnetic resonance imaging (fMRI). I predict that when employing emotion regulation strategies to aversive stimuli, sleep restricted participants and ID patients will have largely overlapping behavioral and neural network outcomes, including impaired ability to volitionally reduce negative behavioral responses, amygdala hyperactivity, and weaker negative connectivity between the amygdala and prefrontal cortex. The study is a necessary next step in determining the behavioral and neural consequences of chronic sleep disruption on the ability to effectively regulate emotions, which can then be used as targets for the development of new therapies. My training plan adeptly complements both the technical and theoretical aspects needed to successfully navigate the proposed project and my trajectory of future research. The selected activities will provide the opportunity to develop expertise in the design of longitudinal sleep studies, fMRI data processing and analysis, theoretical understanding of Insomnia Disorder and its relationship to psychiatric presentations, and how to design and implement large-scale RCTs. Through this award, I will receive the necessary data and training to establish myself as an independent investigator and prepare for future R01 submissions investigating the variance in emotional dysregulation due to sleep disruption relevant to a host of psychiatric conditions.

项目概要 健康的机能需要有能力管理我们的情绪。越来越多的证据表明 睡眠通过维持优化情绪所需的神经回路，在这种适应过程中发挥着至关重要的作用 规定。此外，长期睡眠中断是一个常见特征，并且可能是导致睡眠障碍的根本原因。 许多以情绪和情绪调节受损为特征的精神疾病，例如抑郁症。这 随着人们认识到慢性睡眠障碍更严重，这种关系的后果变得更加可怕。 自杀风险增加一倍以上。拟议研究的目的是确定重叠和 患者临床失眠和健康对照者多晚睡眠不足对睡眠的不同影响 情绪调节任务期间的行为和神经反应。我的中心假设是临床睡眠 干扰和多晚睡眠不足都会破坏成功情绪所需的电路 调节，因此是情绪功能失调的关键驱动因素。主要理由 我们对睡眠紊乱和情绪功能之间关系的大部分理解 依赖于单晚严重睡眠剥夺或对大样本趋势的评估，留下了主要的 在理解更长时间、更长期的睡眠不足对情绪调节的机械影响方面存在差距。这 信息对于了解不同形式的睡眠中断对情绪的影响程度至关重要 以及许多精神疾病中的情绪失调。在拟议的研究中，我将招募以下患者 失眠症（ID；n=25）和经历正常睡眠（n=25）或睡眠限制的健康个体 (n=25) 协议。所有参与者将两次完成情绪调节范式，一次作为 基线，以及功能磁共振成像 (fMRI) 期间的第二次。我预测在雇用时 针对厌恶刺激、睡眠受限的参与者和智力障碍患者的情绪调节策略将在很大程度上 行为和神经网络结果重叠，包括自愿减少负面影响的能力受损 行为反应、杏仁核过度活跃以及杏仁核和杏仁核之间较弱的负连接 前额皮质。这项研究是确定行为和神经后果的必要的下一步 慢性睡眠中断会影响有效调节情绪的能力，然后可以将其用作 新疗法的开发。我的培训计划巧妙地补充了技术和理论方面 需要成功地引导拟议的项目和我未来的研究轨迹。选定的活动 将提供机会发展纵向睡眠研究设计、功能磁共振成像数据处理方面的专业知识 失眠症的分析、理论理解及其与精神病表现的关系， 以及如何设计和实施大规模随机对照试验。通过这个奖项，我将获得必要的数据和 培训使我自己成为一名独立调查员并为未来的 R01 提交调查做好准备 由于与许多精神疾病相关的睡眠中断而导致的情绪失调的差异。