CORE D: Magnetic Resonance Imaging Core (MRIC)

CORE D：磁共振成像核心 (MRIC)

• 批准号: 10450799
• 负责人: GEOFFREY DAVID CLARKE
• 金额: $ 12.53万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10450799
• 关键词: Abdomen; Age; Aging; Algorithmic Software; Algorithms; Anatomy; Bibliography; Biochemical; Biochemical Process; Biochemistry; Biomedical Research; Blood flow; Brain; Cardiac; Cardiovascular system; Clinical; Collaborations; Communities; Computers; Data Analyses; Development; Diabetes Mellitus; Equipment; Fatty acid glycerol esters; Goals; Health care facility; Heart; Heart Diseases; Human; Image; Imaging Techniques; Imaging technology; Institutes; Institution; International; Leadership; Life Cycle Stages; Liver; Longevity; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Metabolic; Metabolic syndrome; Metabolism; Methods; Mission; Modeling; Monitor; Neurologic; Obesity; Organ; Papio; Perfusion; Physiological; Physiological Processes; Physiology; Primates; Procedures; Program Research Project Grants; Research; Research Institute; Research Methodology; Research Personnel; Resource Sharing; Resources; Role; Skeletal Muscle; Standardization; Structure; System; Technology; Texas; Thymus Gland; Tissues; Training; Translational Research; Uterus; Veterinarians; animal imaging; biomedical imaging; hemodynamics; image processing; image translation; imaging facilities; imaging modality; imaging study; in vivo; innovation; instrumentation; minimally invasive; non-invasive imaging; nonhuman primate; normal aging; perinatal intervention; radio frequency; spectroscopic imaging

CORE D: Magnetic Resonance Imaging Core (MRIC) Abstract. The Magnetic Resonance Imaging Core will be located at the UTHSCSA Research Imaging Institute (RII), which is about 5 m miles away from Texas Biomedical Research Institute. The mission of the RII is to provide collaborative access to the biomedical research community advanced, noninvasive, imaging-research methods. This mission is achieved by maintaining a state-of-the-art facility staffed by an internationally recognized team of investigators specializing in the development of imaging methods. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have outstanding trans-species translational- research potential, being applied to non-human primates (NHP) as readily as to humans. The researchers at the RII have used MRI/MRS for studies of baboon brains, hearts and liver, with 26 such studies listed in the bibliography of this section. The aging-developmental programming research group, under Dr. Peter Nathanielsz' leadership, has been at the forefront of introducing non-invasive, advanced biomedical imaging techniques to the study of developmental programming in the baboon model. Dr. Nathanielsz' team has collaborated with RII investigators for the past decade, a collaboration that informs and motivates this core proposal. RII/MRIC imaging instrumentation & expertise emphasizes MRI and MRS because these jointly provide a huge range of anatomical/structural, functional/physiological and biochemical measures with instrumentation dedicated to non-human primate (NHP) research. RII/MIC instrumentation includes a clinical- grade 3 Tesla MRI/MRS system for primate studies. This system is equipped with 32 radiofrequency channels allowing it to perform functional cardiac and neuro MRI studies by taking advantage of parallel imaging technology. RI studies generated in the MRI Core will be used to measure changes in size, function, bulk flow, tissue perfusion, tissue microstructure and in vivo biochemistry. These studies will be carried out in brain, heart, thymus, skeletal muscle and liver/abdomen. Animal-imaging instrumentation is housed with direct access to a state-of-the art veterinary care facility. All baboon MRI studies will be conducted with a certified veterinarian monitoring the subjects through the procedures. In support of this well-coordinated effort by a highly sophisticated team of investigators, the MRI Core will provide translation imaging resources and expertise. Further, for more than two decades the RII has served as a regional and national shared resource, hosting collaborations with investigators from many other institutions. In this proposal, this role is expanded specifically in relation to the consequences of developmental programming of heart disease, diabetes, obesity and metabolic syndrome, and their effects on the life-course of normal aging in the baboon model. The MRI Core supports Projects 1, 2, and 3 of this U19 application. The utility of the MRI Core has been established through previous collaborations jointly involving the Southwest National Primate Research Center and the Barshop Institute for Longevity and Aging Studies. !

CORE D：磁共振成像核心 (MRIC) 抽象的。 磁共振成像核心将位于 UTHSCSA 成像研究所 (RII)， 距德克萨斯生物医学研究所约 5 m 英里。 RII 的使命是提供 与生物医学研究界的协作访问先进的、非侵入性的成像研究 方法。这一使命是通过维护由国际化人员组成的最先进的设施来实现的。 公认的专门从事成像方法开发的研究人员团队。磁共振 成像（MRI）和磁共振波谱（MRS）具有出色的跨物种转化能力 研究潜力，可以像人类一样轻松地应用于非人类灵长类动物（NHP）。研究人员在 RII 使用 MRI/MRS 对狒狒大脑、心脏和肝脏进行研究，其中列出了 26 项此类研究 本节的参考书目。彼得博士领导下的老龄化发展规划研究小组 Nathanielsz 的领导一直处于引入非侵入性先进生物医学成像的最前沿 研究狒狒模型中的发育编程的技术。 Nathanielsz 博士的团队已 过去十年与 RII 研究人员合作，这种合作为这一核心提供了信息并激励了他们 提议。 RII/MRIC 成像仪器和专业知识强调 MRI 和 MRS，因为它们共同作用 提供广泛的解剖/结构、功能/生理和生化测量 专用于非人类灵长类动物 (NHP) 研究的仪器。 RII/MIC 仪器包括临床- 用于灵长类动物研究的 3 级特斯拉 MRI/MRS 系统。该系统配备32个射频通道 使其能够利用并行成像进行功能性心脏和神经 MRI 研究 技术。 MRI Core 中生成的 RI 研究将用于测量尺寸、功能、总体流量、 组织灌注、组织微观结构和体内生物化学。这些研究将在大脑中进行， 心脏、胸腺、骨骼肌和肝脏/腹部。动物成像仪器装有直接 使用最先进的兽医护理设施。所有狒狒 MRI 研究都将由经过认证的人员进行 兽医通过程序监测受试者。为了支持这一协调一致的努力 MRI 核心由高度成熟的研究人员团队提供翻译成像资源和 专业知识。此外，二十多年来，RII 一直作为区域和国家共享资源， 与许多其他机构的研究人员进行合作。在本提案中，这一角色得到了扩展 特别是与心脏病、糖尿病、肥胖症等发育规划的后果有关 和代谢综合征，及其对狒狒模型中正常衰老生命过程的影响。核磁共振成像 Core 支持此 U19 应用程序的项目 1、2 和 3。 MRI Core 的实用性已经确立 通过之前与西南国家灵长类研究中心和 巴肖普长寿与衰老研究所。 ！