Brain Maturation in Adults with FASD

患有 FASD 的成人的大脑成熟度

基本信息

批准号：
10442629
负责人：
EDWARD P RILEY
金额：
$ 33.7万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10442629
关键词：
Address Adolescence Adolescent Adult Affect Age Age-Years Aging Alcohols Anatomy Animal Model Anisotropy Attention deficit hyperactivity disorder Behavior Behavioral Brain Brain scan Cerebral cortex Characteristics Child Classification Clinical Research Cognition Cognitive Data Demographic Factors Development Diffuse Diffusion Diffusion Magnetic Resonance Imaging Disease Down Syndrome Empirical Research Entropy Evaluation Face Family Fetal Alcohol Exposure Fetal Alcohol Spectrum Disorder Fetal Development Fetal alcohol effects Follow-Up Studies Goals Growth Human Image Impaired cognition Individual Knowledge Life MRI Scans Magnetic Resonance Imaging Methods Myelin Neurodevelopmental Disorder Neuropsychological Tests Outcome Parietal Participant Pattern Phase Population Protocols documentation Public Health Publishing Quality of life Recording of previous events Registries Reporting Research Rest Sampling Scanning Seeds Signal Transduction Structure System Techniques Teenagers Testing Time Universities Washington Work age group age related alcohol exposure base behavior test cerebral atrophy connectome data modeling developmental disease disorder control embryo/fetus emerging adult fetal functional MRI scan improved in utero insight myelination neurodevelopment recruit signal processing white matter young adult

项目摘要

Project Summary Exposure to alcohol in utero can have devastating effects on the developing fetus, including growth deficits, cognitive and behavioral anomalies, alterations in brain, and distinct facial characteristics; collectively these are referred to as fetal alcohol spectrum disorders (FASD). While research over the last 40 years has characterized these alterations and provided numerous potential mechanisms for the effects of prenatal alcohol exposure (PAE), very little data exists on long-term consequences as the majority of clinical research has focused on children and adolescents. Many of the consequences of PAE are thought to be lifelong, yet data on individuals past young adulthood are rare, despite animal model data suggesting long-term consequences and altered trajectories of behavioral development. The goal of this application is to address this significant shortfall in our knowledge by evaluating the protracted effects of prenatal alcohol exposure on the brain. Previous large studies from Seattle, WA developed well-characterized research samples of individuals with a classification of having an FASD who are now adults between 30 and 60 years of age. These individuals are currently being recruited into a registry of research participants. Over 150 of these individuals have had previous structural MRI scans conducted while in their teens and twenties. A subset of subjects and matched controls (N=90) will be recruited to have another MRI session in which structural, DTI, and connectivity assessments will be conducted. Comparisons between these and earlier scans will provide insight into the changes in overall brain structure, white matter integrity, and function with age in subjects with alcohol exposure histories. We postulate that brain maturation following PAE follows an altered trajectory relative to normal developing controls. This work will begin to examine a major gap in our knowledge about the impact of PAE by addressing for the first time the longitudinal changes in brain during the adult period, and identify gaps in knowledge regarding FASD in adulthood.

项目概要在子宫内接触酒精会对发育中的胎儿产生毁灭性影响，包括生长缺陷、认知和行为异常、大脑改变以及独特的面部特征；总的来说，这些是称为胎儿酒精谱系障碍 (FASD)。虽然过去 40 年的研究已经描述了这些改变的特征，并提供了产前影响的许多潜在机制酒精暴露（PAE），与大多数临床研究一样，关于长期后果的数据很少重点关注儿童和青少年。 PAE 的许多后果被认为是终生的，但尽管动物模型数据表明长期的，但关于成年后个体的数据很少行为发展的后果和改变的轨迹。该应用程序的目标是解决通过评估产前酒精暴露对胎儿的长期影响，我们的知识存在重大缺陷大脑。之前来自华盛顿州西雅图的大型研究开发了特征良好的研究样本年龄在 30 至 60 岁之间、属于 FASD 分类的个体。这些目前正在招募个人加入研究参与者登记册。其中超过 150 人之前在十几岁和二十多岁的时候就进行过结构性核磁共振扫描。主题的子集和将招募匹配的对照 (N=90) 进行另一次 MRI 会议，其中结构、DTI 和将进行连通性评估。这些与早期扫描之间的比较将提供洞察力研究酒精受试者的整体大脑结构、白质完整性和功能随年龄的变化暴露历史。我们假设 PAE 后的大脑成熟遵循相对于正常发育控制。这项工作将开始检查我们对影响的认识中的一个主要差距 PAE 首次解决成年期大脑的纵向变化，并确定差距成年期有关 FASD 的知识。