Prediction of inertial particle focusing in curved microfluidic ducts.

弯曲微流体管道中惯性粒子聚焦的预测。

• 批准号: DP200100834
• 负责人: Prof Yvonne Stokes
• 金额: $ 26.7万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-22 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100834
• 关键词: Prediction; inertial; particle; focusing; curved

This project aims to develop mathematical models to predict migration of particles suspended in flow through curved microfluidic ducts and their focusing by size to different regions in the cross-section of the duct. New knowledge in mathematics and engineering will be generated through models that capture the two-way force balance between fluid and particles and by a novel use of asymptotics for computational efficiency. Expected outcomes are understanding of the physics that drives particle migration and the parameters that may be used to control particle focusing. This will benefit design and operation of microfluidic devices for particle sorting as required for "liquid biopsy", the isolation of cancer cells in a routine blood sample.

该项目旨在开发数学模型，以预测悬浮在弯曲的微流体管道流中的颗粒的迁移，并将其聚焦在管道横截面中的不同区域的大小上。数学和工程方面的新知识将通过模型来生成，这些模型可以捕获流体和粒子之间的双向力平衡，并通过新的渐近用药来用于计算效率。预期的结果是对驱动颗粒迁移的物理学的理解以及可用于控制粒子聚焦的参数。这将有益于“液体活检”所需的微流体设备的设计和操作，即常规血液样本中癌细胞的分离。