Prediction of inertial particle focusing in curved microfluidic ducts.

弯曲微流体管道中惯性粒子聚焦的预测。

• 批准号: DP200100834
• 负责人: Prof Yvonne Stokes
• 金额: $ 26.7万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-22 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100834
• 关键词: Prediction; inertial; particle; focusing; curved

This project aims to develop mathematical models to predict migration of particles suspended in flow through curved microfluidic ducts and their focusing by size to different regions in the cross-section of the duct. New knowledge in mathematics and engineering will be generated through models that capture the two-way force balance between fluid and particles and by a novel use of asymptotics for computational efficiency. Expected outcomes are understanding of the physics that drives particle migration and the parameters that may be used to control particle focusing. This will benefit design and operation of microfluidic devices for particle sorting as required for "liquid biopsy", the isolation of cancer cells in a routine blood sample.

该项目旨在开发数学模型来预测悬浮在流中的颗粒通过弯曲微流体管道的迁移，以及它们按尺寸聚焦到管道横截面的不同区域。数学和工程方面的新知识将通过捕获流体和粒子之间双向力平衡的模型以及通过渐近学的新颖用途来提高计算效率而产生。预期结果是了解驱动粒子迁移的物理原理以及可用于控制粒子聚焦的参数。这将有利于用于颗粒分选的微流体装置的设计和操作，这是“液体活检”（在常规血液样本中分离癌细胞）所需的。