NEGATIVE COGNITION DEPRESSION--ETIOLOGY AND COURSE

消极认知抑郁--病因和病程

• 批准号: 3383259
• 负责人: LYN Y ABRAMSON
• 金额: $ 55.95万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3383259
• 关键词: clinical depression; cognition disorders; disease /disorder classification; disease /disorder proneness /risk; human subject; longitudinal human study; mental disorder diagnosis; prognosis; psychological tests; questionnaires; relapse /recurrence; self concept; stress

In evaluating research to test the hopelessness theory and Beck's theory of depression, we have arrived at a very disturbing conclusion: the various research strategies used to test these theories do not provide an adequate test of their basic postulates and may produce results that mislead investigators about their validities. In our view, the problems associated with past research strategies result, in part, from investigators' failure to appreciate the full methodological implications of the kinds of causal relations specified in the cognitive theories and, as a corollary, the heterogeneity that may exist among the depressive disorders. Indeed, researchers have not appreciated that these cognitive theories actually hypothesize the existence in nature of an,as yet, unidentified subtype of depression - "negative cognition depression."Thus, the overarching goal of this collaborative grant is to provide a more powerful test of the hopelessness theory's and Beck's theory's predictors regarding the etiology and subsequent course of negative cognition depression and a validation of this subtype of depression. To this end we plan to conduct a large scale, two-year prospective study designed to test the etiological hypotheses of the cognitive theories of depression. In the Vulnerability Study, 420 currently nondepressed, non-psychopathological individuals who are at either high, medium or low risk for depression based on their cognitive styles will be followed prospectively for 2 years, on a monthly basis, with independent and blind self-report and interview assessments of stressful life events, cognitions and psychiatric status/symptomatology in order to predict onsets and subsequent relapses/recurrences of depression. These studies will contribute to the scientific understanding of the etiology of a subset of the affective disorders, to a more valid nosology of the depressive disorders and to the development of interventions for treating and preventing the negative cognition subtype of depression.

在评估研究以测试绝望理论和贝克的理论时 抑郁症，我们得出了一个非常令人不安的结论：各种 用于检验这些理论的研究策略不能提供足够的 测试其基本假设，并可能产生误导的结果 调查人员关于他们的有效性。在我们看来，问题相关的问题 随着过去的研究策略的部分原因，研究人员失败了 欣赏因果关系的全部方法论上的含义 认知理论中指定的关系，作为必然的关系 抑郁症中可能存在的异质性。的确， 研究人员并没有意识到这些认知理论实际上 假设An的本质中的存在是迄今为止未知的亚型 抑郁 - “负认知抑郁。”因此， 这种协作赠款是为了提供更强大的测试 绝望理论和贝克的理论关于病因的预测指标 以及随后的负面认知抑郁和验证 这种抑郁症的亚型。 为此，我们计划进行大规模的两年前瞻性研究 旨在检验认知理论的病因假设 沮丧。在脆弱性研究中，目前有420个不抑郁的人， 高，中或低的非心理病理学个体 将遵循基于认知风格的抑郁症的风险 前瞻性2年，每月一次，独立和盲人 自我报告和访谈评估压力性生活事件，认知 和精神病状态/症状学，以预测和 随后的抑郁症复发/复发。 这些研究将有助于科学理解 情感障碍子集的病因，对更有效的疾病学 抑郁症和开发干预措施 治疗和预防抑郁症的负面认知亚型。