Comparison of Exercise Mode on Disruptions in Calcium Homeostasis

运动模式对钙稳态破坏的比较

• 批准号: 10437654
• 负责人: Sarah J Wherry
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437654
• 关键词: Acute; Address; Adult; Age; Age-Related Bone Loss; Aging; Area; Attenuated; Award; Biological Markers; Blood specimen; Bone Density; Bone Resorption; C-telopeptide; Calcium; Calcium ion; Cardiometabolic Disease; Clinical; Collagen Type I; Cyclophosphamide; Data; Diabetes Mellitus; Educational Status; Elderly; Exercise; Future; Goals; Guidelines; Health; Heart Diseases; Heart Rate; Homeostasis; Hour; Intervention; Knowledge; Lead; Life; Life Style; Measures; N-terminal; Orthopedics; Osteogenesis; Osteoporosis; Outcome; PTH gene; Participant; Population; Prevention strategy; Procollagen; Quality of life; Randomized; Recommendation; Research; Risk; Serum; Stimulus; Testing; Time; Type I Procollagen; Veterans; Walking; Weight; Weight-Bearing state; Woman; aged; bone; bone health; bone loss; bone turnover; calcium supplementation; cardiometabolic risk; cardiometabolism; design; endurance exercise; exercise intensity; exercise intervention; exercise prescription; experience; experimental study; fitness; fracture risk; functional independence; improved; innovation; lifestyle intervention; men; mode of exercise; novel; osteoporosis with pathological fracture; preservation; prevent; response; response biomarker; sex; treadmill

Endurance exercise is frequently recommended as a means to reduce the risk of cardiometabolic diseases and to reduce the risk of osteoporotic fracture. However, bone does not always adapt in the way that would be expected, and there is evidence that endurance exercise may lead to bone loss under certain conditions. It is our contention that disruptions in calcium homeostasis during exercise, resulting in decreases in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and c-telopeptide of type I collagen (CTX; a marker of bone resorption) at the onset of exercise, may be responsible for the lack of improvements in bone mineral density that are anticipated. Acute studies in this area have predominantly focused on young, healthy adults, primarily men, during stationary cycling exercise. Few studies have been conducted in older adults, but those studies have found that older adults experience similar disruptions in calcium homeostasis in response to an acute bout of endurance exercise. Preliminary comparisons of our studies, as well as research from other labs, also suggests that that mode of exercise conducted during these acute exercise bouts may be an important determining factor in the catabolic bone response to exercise. It appears that weight-bearing exercise (i.e., treadmill) results in smaller increases in PTH and CTX compared to weight-supported exercise (i.e., stationary cycling). This has never been tested using a within-subjects design, so it is unclear if these observed differences are due to the mode of exercise, lab-to-lab differences, or other underlying factors. To address this gap in knowledge, 30 Veterans (15 men, 15 women), aged 60+ years, will complete two 1-hour acute exercise bouts: 1) brisk treadmill walking at 70-80% of maximal heart rate; 2) vigorous stationary cycling at 70-80% maximal heart rate. Blood samples will be collected to measure iCa, PTH, CTX and procollagen type I n- terminal propeptide (P1NP) before, during, and after each exercise bout. The order of the exercise bouts will be randomized and counter-balanced. The primary aim is to determine if mode of exercise results in a differential bone biomarker response in older Veterans. This information is essential for understanding how future exercise interventions should be designed to benefit both cardiometabolic health and bone health. This is especially relevant to Veteran health due to the high burden of both cardiometabolic diseases (e.g., diabetes, heart disease) in the population, as well as evidence of increased osteoporotic fracture risk. The proposed research is significant because it is addressing a knowledge gap that has prevented the ability to design exercise and lifestyle interventions aimed at preserving multiple components of Veteran health, which could have a lasting impact on Veteran quality of life and functional independence. The proposed research is innovative because it is testing a novel hypothesis, the mode of exercise on disruptions in calcium homeostasis, in a population that could greatly benefit from the knowledge to be gained. While the proposed research is an acute study, the results generated will be used to design future clinical interventions for Veteran health. Long-term, information gained from this research will help to define the optimal exercise prescription to improve cardiometabolic without compromising bone health aging Veterans.

耐力运动经常被推荐作为降低心脏代谢疾病风险的一种手段 并降低骨质疏松性骨折的风险。然而，骨骼并不总是以应有的方式适应 预期，并且有证据表明耐力运动在某些情况下可能会导致骨质流失。这是 我们的观点是，运动过程中钙稳态被破坏，导致血清离子浓度降低 钙 (iCa) 以及甲状旁腺激素 (PTH) 和 I 型胶原蛋白 C 端肽 (CTX；一种标记物) 的增加 运动开始时的骨吸收）可能是导致骨矿物质缺乏改善的原因 预期的密度。这一领域的急性研究主要集中在年轻、健康的成年人， 主要是男性，在固定自行车运动中。在老年人中进行的研究很少，但这些研究 研究发现，老年人的钙稳态也会受到类似的破坏，以应对 剧烈的耐力运动。我们的研究以及其他实验室的研究的初步比较， 还表明，在这些急性锻炼期间进行的锻炼方式可能是一个重要的因素 骨分解代谢对运动的反应的决定因素。看来负重运动（即 与负重运动（即静止运动）相比，跑步机）导致 PTH 和 CTX 的增加较小 骑自行车）。这从未使用受试者内设计进行过测试，因此尚不清楚这些是否观察到 差异是由于运动方式、实验室之间的差异或其他潜在因素造成的。为了解决这个问题 知识差距，30 名 60 岁以上退伍军人（15 名男性，15 名女性）将完成两次 1 小时的急性锻炼 训练次数： 1) 在跑步机上以最大心率的 70-80% 快走； 2) 70-80% 的剧烈静态循环 最大心率。将采集血样以测量 iCa、PTH、CTX 和 I 型前胶原 每次运动之前、期间和之后的末端前肽 (P1NP)。练习回合的顺序将 是随机和平衡的。主要目的是确定锻炼方式是否会导致 老年退伍军人的骨生物标志物反应差异。此信息对于了解如何 未来的运动干预措施应旨在有益于心脏代谢健康和骨骼健康。这 由于两种心脏代谢疾病的高负担（例如， 糖尿病、心脏病），以及骨质疏松性骨折风险增加的证据。这 拟议的研究意义重大，因为它正在解决阻碍了能力的知识差距 设计锻炼和生活方式干预措施，旨在保护退伍军人健康的多个组成部分， 可能会对退伍军人的生活质量和功能独立性产生持久影响。拟议的研究是 创新是因为它正在测试一个新的假设，即运动模式对钙的破坏 体内平衡，可以从所获得的知识中大大受益的人群。虽然提议的 研究是一项急性研究，产生的结果将用于为退伍军人设计未来的临床干预措施 健康。从长远来看，从这项研究中获得的信息将有助于确定最佳的运动处方 改善心脏代谢而不损害骨骼健康老龄退伍军人。