STRESS AND REPRODUCTIVE HORMONES IN DEPRESSED WOMEN

抑郁女性的压力和生殖激素

• 批准号: 2249391
• 负责人: ELIZABETH ANN YOUNG
• 金额: $ 23.19万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2249391
• 关键词: adrenocorticotropic hormone; catheterization; cortisol; depression; dexamethasone; eating disorders; estradiol; female; female reproductive system disorder; follicle stimulating hormone; gonadotropin releasing factor; hormone regulation /control mechanism; human subject; hypothalamic pituitary adrenal axis; luteinizing hormone; menstrual cycle; neuropsychology; pituitary gonadal axis; progesterone; secretion; stress; weight loss

Depression is a disorder, with a strong predilection for women. Abnormalities of several hormonal axes particularly the adrenal (stress) and thyroid axes have been well documented in depressed women,'but few studies have explored the hypothalamic pituitary gonadal (HPG) axis. The occurrence of sex bias in the expression of depressive illness after the onset of puberty, as well as anecdotal studies suggesting an association between mood and cyclic gonadal steroid changes suggest that gonadal axis hormones may modulate the onset and course of depression. Hormones of the hypothalamic pituitary adrenal (HPA) axis have been demonstrated to affect the hypothalamic pituitary gonadal axis, particularly the secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus. Hypothalamic amenorrhea, exercise induced amenorrhea and anorexia nervosa all demonstrate activation of the HPA axis accompanying the abnormalities in GnRH and LH secretion. This suggests that activation of the HPA axis is closely linked to abnormal GnRH secretion in humans. This project proposes to study the interactions between these two hormonal axes (stress and gonadal) to determine if depression in women is accompanied by abnormalities in reproductive axis hormones and if abnormalities in the reproductive axis are linked to abnormalities in the HPA axis, or if the two abnormalities can co-exist independently. To characterize baseline secretion in these two axes, overnight, continuous withdrawal catheter studies using 5 minute integrated sampling will be conducted in depressed women to examine pulsatile secretion of the gonadal hormones (LH, FSH, estradiol and progesterone) as well as pulsatile secretion of the stress axis hormones (ACTH and cortisol). These data will be compared with data from control women matched for age and menstrual cycle day. In depressed women pulse frequency and amplitude of LH secretion will each be examined, as well as frequency and amplitude of ACTH and cortisol pulses. GnRH secretion, as assessed by LH secretion in the periphery, appears to be the most sensitive index of disruptions in HPG axis secretion, but gonadal steroid hormones will also be evaluated. The data on HPA axis pulsatility will determine if secretory drive in depressed women increases in the zenith and nadir of the circadian rhythm, and if the onset of circadian driven secretory episodes shift in depressed women. In normal women, the influence of gonadal axis hormones on functioning of the HPA axis will be explored by comparing the two axes and the response to dexamethasone at different phases of the menstrual cycle in a subgroup of the control women. It is hoped that these data will contribute to our understanding of the impact of stress and HPA axis activation on the reproductive axis in women, as well as furthering our knowledge about abnormalities in gonadal hormones in depressed women.

抑郁症是一种疾病，对女性有很大的偏爱。 几个激素轴，特别是肾上腺（应力）的异常 甲状腺轴在沮丧的女性中已经有充分的记录，但很少 研究探索了下丘脑垂体性腺（HPG）轴。这 性偏见在表达抑郁疾病之后的发生 青春期的发作以及轶事研究表明了关联 在情绪和循环性腺类固醇之间的变化之间表明性腺轴 激素可能会调节抑郁症的发作和过程。激素 已经证明下丘脑垂体肾上腺（HPA）轴影响 下丘脑垂体性腺轴，尤其是分泌 促性腺激素从下丘脑释放激素（GNRH）。下丘脑 闭经，运动诱导的闭经和神经性厌食症 证明伴随异常的HPA轴激活 GnRH和LH分泌。这表明HPA轴的激活是 与人类的GNRH分泌有着密切相关。该项目提出了建议 研究这两个激素轴之间的相互作用（应力和 性腺）确定女性的抑郁症是否伴随 生殖轴激素的异常和if nrormalinal in 生殖轴与HPA轴异常有关，或者 两个异常可以独立共存。表征基线 这两个轴的分泌，一夜之间，连续退出导管 使用5分钟的集成抽样的研究将在抑郁中进行 妇女检查性腺激素的脉动分泌（LH，FSH， 雌二醇和孕酮）以及应力的脉动分泌 轴激素（ACTH和皮质醇）。这些数据将与数据进行比较 从对照妇女匹配年龄和月经周期。沮丧 将检查女性脉搏频率和LH分泌的幅度 以及ACTH和皮质醇脉冲的频率和振幅。 gnrh 分泌物在外围的LH分泌评估，似乎是 HPG轴分泌中最敏感的索引，但性腺 类固醇激素也将进行评估。 HPA轴脉动性的数据 将确定沮丧妇女的分泌驱动力是否增加 昼夜节律的Zenith和Nadir，以及昼夜节律的发作 驱动的分泌情节在沮丧的女性中发生了变化。在普通女性中 性腺轴激素对HPA轴功能的影响将是 通过比较两个轴和对地塞米松的响应来探索 月经周期的不同阶段 女性。希望这些数据将有助于我们的理解 应力和HPA轴激活对生殖轴的影响 妇女，以及我们对性腺异常的了解 抑郁妇女中的激素。