ALZHEIMER'S DISEASE RESEARCH CENTER

阿尔茨海默病研究中心

• 批准号: 3104718
• 负责人: ROBERT KATZMAN
• 金额: $ 172.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-28 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104718
• 关键词: Alzheimer's disease; human subject

This proposal is for a five-year renewal of the Alzheimer's Disease Research Center at the University of California at San Diego (UCSD) in consortium with the Salk Institute. The major objective of our ADRC is to enhance research into Alzheimer's disease (AD), a disorder which is a major disabling disease of the elderly accounting for half of nursing home admissions as well as increasing mortality rate and impacting severely upon families and caregivers. We have sought to enlist investigators and develop resources necessary to move forward in a significant way in the understanding of the pathogenesis and pathophysiology of AD with the ultimate goal of learning enough about the disease to be able to prevent or alter its clinical course, at the same time improving our understanding of the clinical diagnosis, course and the relationship of neuropsychological dysfunction to specific brain lesions. The ADRC provides a clinical and neuropathological resource based upon annual evaluations of a cohort of volunteers willing to participate in clinical research, subjects with Alzheimer's disease and related disorders and normal aged matched volunteers. The Clinical Core activity provides subjects for research and pilot projects and also permits study of clinical and neuropsychological changes during the course of AD; forms the base for development of cross- cultural studies of AD, specifically, Hispanic, Chinese and Finnish studies; enables participation in multicenter drug studies and national registries such as CERAD and THA; generates a well edited longitudinal data base. The Neuropathological Core provides a source of brain tissue of patients characterized clinically and neuropathologically for use in research projects. The ADRC provides a setting to facilitate research training of AD investigators and information transfer to the professional and lay communities through our mini-residency program, conferences and other educational activities. We foster interdisciplinary research activities through collaborations, seminars, feasibility and pilot projects. Our specific research projects in this renewal include investigations of the precursor protein for the Beta amyloid present in neuritic plaques (Research Project 1); the specific nature of the memory and other cognitive deficits in the Alzheimer process (Research Project 2); the quantitative anatomical study of Alzheimer brain in regard to neuronal populations in dementia (Research Project 3); and the effect of nerve growth factor as a potential therapeutic modality (Research Project 4); The UCSD ADRC fosters new research initiatives through pilot and feasibility projects which span disciplines from electronmicroscopy to electrophysiology, from clinical psychiatry to neuro-ophthalmology and which involve faculty at neighboring institutions in San Diego as well as at UCSD.

该建议是针对阿尔茨海默氏病的五年续约 加州大学圣地亚哥分校（UCSD）的研究中心 萨尔克研究所的财团。我们ADRC的主要目标是 加强对阿尔茨海默氏病（AD）的研究，这是一种主要的疾病 致残的老年人疾病疗养院一半 入院以及增加死亡率并严重影响 家庭和照顾者。我们试图参与调查人员并发展 以重大方式前进所必需的资源 了解AD的发病机理和病理生理学 对疾病的学习足够的最终目标，能够预防或 改变其临床过程，同时提高我们对 神经心理学的临床诊断，过程和关系 特定脑病变功能障碍。 ADRC提供了临床和 基于对同类的年度评估的神经病理资源 愿意参加临床研究的志愿者 阿尔茨海默氏病和相关疾病和正常老年匹配 志愿者。临床核心活动为研究提供了主题和 试点项目，还允许研究临床和神经心理学 广告过程中的变化；构成了跨界发展的基础 广告的文化研究，特别是西班牙裔，中国和芬兰语 研究；使参与多中心药物研究和国家 Cerad和Tha等登记处；生成良好编辑的纵向数据 根据。神经病理核心提供了脑组织的来源 患者在临床和神经病理学上的特征在于 研究项目。 ADRC提供了促进研究的设置 培训广告调查人员和信息转移给专业人士 并通过我们的迷你居住计划，会议和 其他教育活动。我们培养跨学科研究 通过合作，研讨会，可行性和飞行员的活动 项目。我们在此续签中的特定研究项目包括 研究存在于β淀粉样蛋白的前体蛋白 神经斑块（研究项目1）；记忆的特定本质 以及阿尔茨海默氏症过程中的其他认知缺陷（研究项目2）； 关于神经元的阿尔茨海默氏症大脑的定量解剖学研究 痴呆症的人群（研究项目3）；和神经的影响 生长因子是一种潜在的治疗方式（研究项目4）；这 UCSD ADRC通过飞行员和可行性促进了新的研究计划 从电子显微镜到跨越学科的项目 电生理学，从临床精神病学到神经浏览学和 涉及圣地亚哥邻近机构的教师以及 在UCSD。