PATIENT CENTERED OUTCOMES METHOD FOR NEUROLOGIC DISEASE

神经系统疾病以患者为中心的结果方法

• 批准号: 2237063
• 负责人: CAROLYN EMILY SCHWARTZ
• 金额: $ 2.71万
• 依托单位: FRONTIER SCIENCE & TECH RESEARCH FDN,INC
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2237063
• 关键词: PATIENT; CENTERED; OUTCOMES; METHOD; NEUROLOGIC

The purpose of this project is to develop a new patient-centered outcomes methodology for chronic neurologic diseases which will eventually be used to develop practice guidelines for cost-effective and efficacious preventive treatment. This project will use multiple sclerosis (MS) as a model, and will apply a utility-based approach which integrates patient preferences, neurologic function, and societal cost in its evaluation of treatment trade-offs. This methodology requires validating a set of sensitive, reliable, and valid neurologic and patient-preference assessment tools, considering a series of societal cost models, and integrating them in the evaluation of clinical research on pharmaco- and rehabilitation therapies. The investigation will proceed in two phases. First, psychometric analyses will be done on preliminary versions of the proposed tools using available cross-sectional and longitudinal data. Second, data will be collected for two years from 230 MS patients undergoing pharmaco or rehabilitation therapies. Several health state models of societal cost will be used to evaluate the cost-effectiveness and -efficacy of these interventions. Future work will extend this -work to practice guidelines and to other chronic neurologic diseases.

该项目的目的是开发以患者为中心的新结果 慢性神经系统疾病的方法最终将使用 制定实践指南以具有成本效益和有效性 预防治疗。该项目将使用多发性硬化症（MS）作为 模型，并将采用基于公用事业的方法来整合患者 偏好，神经功能和社会成本在评估中 治疗权衡。 此方法需要验证一组敏感，可靠和 有效的神经系统和患者预先评估工具，考虑到 一系列社会成本模型，并将它们整合到评估中 关于药物和康复疗法的临床研究。这 调查将分为两个阶段。首先，心理测量分析 将在提议的工具的初步版本上使用 可用的横截面和纵向数据。第二，数据将是 从接受Pharmaco或 康复疗法。几种健康状态的社会成本模型 将用于评估这些成本效益和效能 干预措施。未来的工作将扩展这项工作以练习指南 以及其他慢性神经系统疾病。