PEDIATRIC ONCOLOGY GROUP

儿科肿瘤组

• 批准号: 2084519
• 负责人: TERESA J. VIETTI
• 金额: $ 21.58万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1995-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2084519
• 关键词: clinical trials; cooperative study; human subject; neoplasm /cancer therapy; pediatric neoplasm /cancer

The Children's Cancer Center at St. Louis Children's Hospital, Washington University School of Medicine, is one of the 30 full member institutions, 29 affiliate, 12 consortia and 9 CCOP institutions of the Pediatric Oncology Group who have pooled their patient resources and scientific expertise to study the natural history of childhood cancer, develop and compare effective therapeutic regimens and investigate the toxicity and effectiveness of new anticancer agents in the treatment of children with cancer. The investigators at Washington University include pediatric oncologists, radiologists, radiation therapists, neurologists, surgeons, and pathologists. All children with malignant disease are placed on cooperative group protocols if they are eligible, and if informed consent is obtained. Data accessioned at the time the patient is placed on study protocol, during the study, and when off therapy is submitted to the Group Statistical Office for data analysis, interpretation and eventual publication. The investigators at Washington University serve in multiple administrative and research capacities for the Group. The diagnostic studies, pathological findings, surgical procedure and therapeutic plan for all new patients and patients who relapse are discussed at the weekly Tumor Board Conference. Access to intensive multimodal therapy and experiment compounds is facilitated by the close contact of our institution with the nearby Pediatric Oncology Group Operations Office and with the Group Chairman who is one of our investigators. The Principal Investigator directs the single largest therapeutic Group study (for newly diagnosed non-T, non-B acute lymphoblastic leukemia), and the laboratory of another investigator serves as the Pediatric Oncology Group Reference Laboratory for the study of N-myc and N-ras oncogene activation, and for the establishment of lymphoblastoid cell lines from patients with neuroblastoma.

华盛顿圣路易斯儿童医院的儿童癌症中心 大学医学院是30个正式机构之一， 29分支机构，12个财团和9个CCOP机构 汇集了患者资源和科学的肿瘤学小组 研究儿童癌症，发展和发展的专业知识 比较有效的治疗方案并研究毒性和 新抗癌药在治疗儿童的有效性 癌症。 华盛顿大学的调查人员包括儿科 肿瘤学家，放射科医生，放射治疗师，神经病学家，外科医生，外科医生 和病理学家。 所有患有恶性疾病的儿童均被置于 合作小组协议（如果有资格），如果有知情同意 获得。 将患者进行研究时登录的数据 协议，在研究期间以及未接受治疗时 小组统计办公室用于数据分析，解释和最终 发布。 华盛顿大学的调查人员在 该小组的多个行政和研究能力。 这 诊断研究，病理发现，外科手术和 所有新的新患者的治疗计划是 在每周的肿瘤委员会会议上讨论。 访问密集 多模式疗法和实验化合物促进了关闭 与附近的儿科肿瘤学集团联系我们机构 运营办公室以及我们是我们的团体主席之一 调查人员。 主要研究人员指导最大的 治疗组研究（对于新诊断的非T，非B急性 淋巴细胞白血病）和另一位研究者的实验室 作为研究的小儿肿瘤学组参考实验室 N-Myc和N-Ras癌基因的激活，以及建立 来自神经母细胞瘤患者的淋巴母细胞细胞系。