BIOACTIVE AGENTS FROM DRYLAND PLANTS OF LATIN AMERICA

来自拉丁美洲旱地植物的生物活性剂

• 批准号: 2291803
• 负责人: BARBARA N TIMMERMANN
• 金额: $ 56.16万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2291803
• 关键词: BIOACTIVE; AGENTS; DRYLAND; PLANTS; LATIN

This International Cooperative Biodiversity Group was assembled in response to RFA No. TW-92-0I. The objective of this 5-year project is to discover and develop pharmaceuticals and crop-protection agents from plants of arid and semi-arid ecosystems in Latin America to promote sustained economic growth while conserving biological resources in these fragile environments. Plants will be collected from poorly known floristic areas of Mexico, Chile and Argentina. To collect the greatest diversity of plants for a comprehensive screening program, an ethnobotanical as well as a random pattern approach will be employed by the Latin American collaborators. A specific aim will be to collect a minimum of 600 species of higher plants per year. The collected samples will be processed to obtain a minimum of 1,200 crude extracts for a battery of biological testings in the U.S. These will be evaluated by our collaborators for novel lead compounds in a) binding (receptor target) and enzyme assays; active samples will be followed up by concentration response and bioresponse assays as well as anti-microbial and anti-viral bioassays. Therapeutic areas of potential target application include: central nervous system, cardio-vascular, intermediary metabolism, allergy/inflammation, gastrointestinal, cancer, anti-virals and anti-bacterials. Recollection of those plants showing biological activity in primary and secondary screens will be done to provide sufficient plant material for isolation, structural characterization and further testing of the biodynamic principles using a bioassay-guided approach in Associate Projects 2 and 3. An information management component will be organized to insure a timely and efficient transfer of information between members of each associate project as well as between countries, industrial collaborators and the U.S. Scientific coordinator. Prior to exploitation of a newly discovered biological product, critical issues concerning implications for biodiversity and sustained economic growth will be identified and strategies for minimizing negative impacts and guaranteeing local community benefits will be developed.

这个国际合作生物多样性小组集会 对RFA的响应TW-92-0i。这个5年项目的目的是 发现和开发药品和农作物保护剂 拉丁美洲的干旱和半干旱生态系统的植物促进 持续经济增长，同时保存生物资源 脆弱的环境。 植物将从墨西哥鲜为人知的植物区域收集 智利和阿根廷。收集植物的最大多样性 综合筛查计划，一种民族植物学和随机的 图案方法将由拉丁美洲合作者采用。一个 具体目的是收集至少600种高级植物 每年。 收集的样品将进行处理以获得至少1200个原油 在美国进行一系列生物学测试的提取物将是 由我们的合作者评估用于新型铅化合物A）绑定 （受体靶标）和酶测定；主动样品将随后 浓度响应和生物响应测定以及抗微生物 和抗病毒生物测定。潜在靶标的治疗领域 应用程序包括：中枢神经系统，心血管，中介 代谢，过敏/炎症，胃肠道，癌症，抗病毒 和抗菌。 回忆那些在原发性和 将进行次要屏幕以提供足够的植物材料 隔离，结构表征和进一步测试 使用生物测定指导的方法中的生物动力原理 项目2和3。 将组织信息管理组件以确保及时确保 和有效的信息传输在每个同伴的成员之间 各国，工业合作者和之间的项目以及 美国科学协调员。 在开发新发现的生物产品之前，关键 关于生物多样性和持续经济的影响的问题 将确定增长和最大程度地减少负面影响的策略 并保证将开发当地社区福利。