Prevention of obesity in Infants of overweight and obese women

预防超重和肥胖女性婴儿的肥胖

基本信息

批准号：
10409647
负责人：
Mina Desai
金额：
$ 19.26万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10409647
关键词：
Address Adult Age-Months Animals Birth Body mass index Brain Breast Feeding Calories Childhood Clinical Trials Cognitive Desire for food Development Dietary intake Eating Economic Burden Energy Intake Environment Epidemic Epigenetic Process Exhibits Exposure to Fatty acid glycerol esters Food Intake Regulation Fostering Gender Generations Gestational Age Growth High Fat Diet Human Milk Hyperphagia Hypothalamic structure Incidence Infant Infant Development Infant Food Infant formula Intake Interruption Intervention Laboratory Study Leptin resistance Life Litter Size Metabolic syndrome Milk Nerve Degeneration Neurodevelopmental Disorder Neurons Newborn Infant Non obese Nutritional Obesity Overweight Perinatal Prevention strategy Public Health Rattus Risk Satiation Signal Transduction Structure of nucleus infundibularis hypothalami Weight Weight Gain Woman adult obesity clinical application early-onset obesity excessive weight gain fetal in utero increased appetite infant adiposity innovation maternal obesity milk intake newborn adiposity novel obese mothers obesity in children obesity prevention offspring prevent programs rapid weight gain relating to nervous system

项目摘要

Throughout the world, obesity and metabolic syndrome are an ongoing epidemic crisis, presenting major public health challenges and significant economic burdens. The developmental programming effects of the in-utero environment is demonstrated by the increased risk of large for gestational age (LGA) newborns and childhood and adult obesity in offspring of overweight/obese (OW/OB) mothers. Animal studies have confirmed that maternal obesity and high fat diet programs the offspring appetite center, the arcuate nucleus, resulting in offspring hyperphagia and rapid weight gain, contributing to the generational cycle of obesity. Compounding the effect of programmed hyperphagia is the impact of breast milk caloric content. Despite evidence that breastfeeding reduces the incidence of childhood obesity, breastfeed LGA infants’ childhood obesity rates are nearly 50% greater than formula fed appropriate for gestational age infants. Maternal BMI and dietary intake are highly correlated with milk total calorie and fat content. Our laboratory studies show that offspring born to and nursed by obese rat dams exhibit hyperphagia and develop early life and adult obesity. In contrast, if these offspring are cross fostered and nursed by non-obese dams (matched for gender and litter-size), the offspring grow to normal weight and BMI as adults. These studies suggest that despite programmed offspring hyperphagia at birth, the restriction to control dam milk prevents excessive newborn weight gain and obesity. We propose that normalized caloric intake and newborn growth will prevent the onset of infant obesity, hyperleptinemia (and leptin resistance), and thus normalize appetite throughout childhood. The proposed studies will 1) Confirm that OW/OB mothers’ milk has increased total calorie content and that infants of OW/OB mothers have increased milk intake, and as an intervention 2) Determine if titrated human milk or formula calorie intake prevents excessive infant weight gain in the first six months of life. This highly innovative study will examine the potential efficacy of a novel preventative strategy to prevent the development of infant obesity and interrupt the generational cycle of obesity.

在世界范围内，肥胖和代谢综合征是一场持续的流行病危机，带来了重大的公共卫生挑战和重大的经济负担。宫内环境对发育规划的影响表现为大于胎龄 (LGA) 新生儿和新生儿风险的增加。超重/肥胖 (OW/OB) 母亲的后代的儿童期和成年肥胖动物研究证实，母亲肥胖和高脂肪饮食会影响后代食欲中枢、弓状核，导致后代食欲过盛和体重快速增加，从而导致后代肥胖。世代循环母乳热量含量的影响加剧了程序性食欲过盛的影响，尽管有证据表明母乳喂养可降低儿童肥胖的发生率，但母乳喂养的 LGA 婴儿的儿童肥胖率比适合胎龄婴儿的配方奶喂养高出近 50%。 BMI 和饮食摄入量与牛奶总热量和脂肪含量高度相关，肥胖母鼠所产下的后代表现出食欲过盛，并会出现早期肥胖和成年肥胖。这些后代由非肥胖母鼠（性别和产仔数相匹配）交叉饲养和喂养，后代成年后体重和体重指数均正常。这些研究表明，尽管子代在出生时有程序性的食欲亢进，但控制母乳的限制却很大。防止新生儿体重过度增加和肥胖。我们建议，正常化的热量摄入和新生儿生长将防止婴儿肥胖、高瘦素血症（和瘦素抵抗）的发生，从而使整个儿童期的食欲正常化。确认 OW/OB 母亲的乳汁总热量含量有所增加，并且 OW/OB 母亲的婴儿的乳汁摄入量有所增加，并作为干预措施 2) 确定滴定母乳或配方奶热量摄入是否可以防止婴儿在前 6 天内体重过度增加这项高度创新的研究将检验一种新型预防策略的潜在功效，以预防婴儿肥胖的发生并中断肥胖的代际周期。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

High-Fat, High-Calorie Breast Milk in Women with Overweight or Obesity and Its Association with Maternal Serum Insulin Concentration and Triglycerides Levels.

超重或肥胖女性的高脂肪、高热量母乳及其与母亲血清胰岛素浓度和甘油三酯水平的关系。

DOI：
发表时间：
2024-01-23
期刊：
影响因子：
0
作者：
Ross, Michael G;Kavasery, Manasa P;Cervantes, MacKenzie K;Han, Guang;Horta, Bernardo;Coca, Kelly P;Costa, Suleyma O;Desai, Mina
通讯作者：
Desai, Mina

TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice.

TNFα 诱导的氧化应激和线粒体功能障碍改变下丘脑神经发生并促进小鼠食欲与饱腹感神经肽的表达。

DOI：
发表时间：
2022-07-09
期刊：
影响因子：
3.3
作者：
Desai, Mina;Stiles, Linsey;Torsoni, Adriana S;Torsoni, Marcio A;Shirihai, Orian S;Ross, Michael G
通讯作者：
Ross, Michael G