ADRENAL ANDROGEN EXCESS IN HYPERANDROGENIC OLIGO-OVULATION

高雄激素性少排卵时肾上腺雄激素过多

• 批准号: 5215656
• 负责人: RICARDO AZZIZ
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5215656
• 关键词: adrenal disorder; adrenocorticotropic hormone; androgens; clinical research; corticotropin releasing factor; female; female reproductive system disorder; human subject; ovulation; pathologic process; pituitary disorders; women's health

These investigations have the objective of determining the role that excess adrenocortical sensitivity to adrenocortical hormone (ACTH) stimulation plays in the adrenal androgen excess present in over 50% of women with hyperandrogenic oligo-ovulation. It should be noted that hyperandrogenic oligo-ovulation is the most common cause of ovulatory disorders in women, and that androgen excess (hyperandrogenism) affects approximately 5% of the female population, making it one of the most common reproductive endocrine disorders known to man. While the majority of these women have excess ovarian production of androgens, up to 50% of these women will have excessive adrenal androgen secretion. By investigating the etiology of this abnormality, a potential underlying cause for the overall androgen excess may be elucidated. To date we have studied 9 control subjects, 14 hyperandrogenic oligo-ovulatory women with elevated DHEAS (an adrenal androgen) and 11 hyperandrogenic oligo-ovulatory patients with normal DHEAS levels in this study. The protocol examines both the adrenocortical sensitivity to ACTH, as well as the hypothalamic-pituitary-axis sensitivity to ovinecorticotropin releasing hormone (oCRH). We have had to delay further recruitment of patients into the study since the manufacturer of oCRH (ACTHREL, Ferring Laboratories) has withdrawn the product temporarily while control issues were being addressed. We essentially have not had this medication since September 22, 1995. We expect to continue and complete the recruitment of all subjects (30 each of controls, hyperandrogenic patients with adrenal androgen excess, and hyperandrogenic patients without adrenal androgen excess) by the end of 1996.

这些调查的目的是确定 对肾上腺皮质激素（ACTH）的过度肾上腺皮质敏感性 超过50％以上的肾上腺雄激素过量刺激发挥 具有高雄激素寡卵形的女性。 应该指出的是 高雌激素的寡卵形是排卵的最常见原因 女性的疾病以及雄激素过量（高狂力）会影响 大约5％的女性人口，使其成为最多的 人类已知的常见生殖内分泌疾病。 而多数 这些妇女中有多达卵巢的生产过多，多达50％ 这些妇女将过度肾上腺雄激素分泌。 经过 研究这种异常的病因，这是潜在的潜在 总体雄激素过量的原因可能被阐明。 迄今为止，我们研究了9个对照受试者，14个高狂热性 DHEAS升高（肾上腺雄激素）和11 在此中，DHEAS水平正常的高雄激素性寡卵管患者 学习。 该协议检查了肾上腺皮质的敏感性 ACTH以及下丘脑 - 垂体轴对 Ovinecorticotropin释放激素（OCRH）。 我们不得不延迟 由于制造商 OCRH（ACTHREL，FERRING LABORATORIES）已撤回该产品 在解决控制问题的同时暂时。 我们本质上 自1995年9月22日以来，还没有服用这种药物。我们希望 继续并完成所有受试者的招聘（每个主题30个 对照，肾上腺雄激素过量的高雌激素患者，以及 在没有肾上腺雄激素过剩的情况下）到结束时 1996。