PREVENTIVE ONCOLOGY AWARD

预防肿瘤学奖

• 批准号: 2104885
• 负责人: Sara S. Strom
• 金额: $ 8.38万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2104885
• 关键词: African American; DNA damage; Hodgkin's disease; Mexican Americans; antineoplastics; cancer prevention; cancer risk; chemical carcinogen; chemical carcinogenesis; cytogenetics; drug adverse effect; family genetics; genetic markers; human subject; interview; longitudinal human study; lung neoplasms; mutagen testing; mutagens; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplasm /cancer pharmacology; oncology; reproduction

This proposal describes a plan for a Preventive Oncology Academic Award and my personal development towards a multi-disciplinary approach to cancer epidemiology. Two project are described, the first one analyzes the extent to which heredity contributes to lung cancer etiology in two different ethnic groups, African Americans and Mexican Americans and in patients diagnosed before 45 years of age. This project is built upon an on-going study. During the award period, we will obtain detailed environmental and family history information from personal interviews. These data will be integrated with cyto- and molecular genetic markers. Using a family study design and segregation analysis (mixed and regressive models) as the primary statistical tool, we will determine: a) risk of cancer in relatives and patient's clinical and demographic characteristics associated with such increase; b) etiologic model(s) and parameter estimates; c) genetic heterogeneity to establish whether certain molecular, cytogenetic, clinical, and demographic parameters can discriminate between the hereditary and non-hereditary cases; d) identify specific kindreds for linkage analysis. These studies will enhance the knowledge of gene-environment interactions in lung carcinogenesis, identify groups of individuals and families who are at increased risk, and may help in identifying oncogenic mechanisms. In the second project we will analyze mutagen sensitivity in a cohort of 225 adult Hodgkin's disease patients enrolled since 1987 in a study of genotoxicity. During this award period, we will interview the patients to collect epidemiological data (risk factors, family history of cancer, reproductive history, second malignancies). Annual follow-up contacts will be done to update health histories. Epidemiologic and cytogenetic data will be integrated to analyze baseline, inter- and intra-individual differences in susceptibility to genetic damage. We will determine long-term genotoxicity of different treatments and the risk of adverse outcomes (second malignancies and reproductive events). The research projects outlined in this award will broaden my understanding of the interactions of cyto and molecular genetic markers and epidemiologic risk factors related to the etiology of lung cancer and in the understanding of genetic susceptibility induced by chemotherapeutic treatments.

该建议描述了预防肿瘤学学术奖的计划 以及我采用多学科方法的个人发展 癌症流行病学。描述了两个项目，第一个分析了 遗传在两种中有助于肺癌病因的程度 不同的族裔，非裔美国人和墨西哥裔美国人以及 45岁之前诊断出的患者。该项目建立在一个 正在进行的研究。在奖励期内，我们将获得详细的 来自个人访谈的环境和家族史信息。 这些数据将与细胞和分子遗传标记集成。 使用家庭研究设计和隔离分析（混合和回归 ）作为主要统计工具，我们将确定：a） 亲戚的癌症以及患者的临床和人口统计学特征 与这种增加有关； B）病因模型和参数 估计； c）遗传异质性确定是否确定 分子，细胞遗传学，临床和人口参数可以 区分遗传和非遗传病例； d）确定 特定的链接分析。这些研究将增强 对肺癌发生中基因环境相互作用的知识， 确定风险增加的个人和家庭群体，并且 可能有助于识别致癌机制。在第二个项目中 将分析225个成年霍奇金的队列中的诱变敏感性 自1987年以来，疾病患者从事遗传毒性研究。期间 在这个奖励期，我们将采访患者收集 流行病学数据（风险因素，癌症家族史，生殖 历史，第二个恶性肿瘤）。年度后续联系将进行 更新健康历史。流行病学和细胞遗传学数据将是 整合以分析基线，间和个体内部差异 对遗传损害的敏感性。我们将确定长期的遗传毒性 不同的治疗和不良后果的风险（第二 恶性和生殖事件）。研究项目概述了 该奖项将扩大我对Cyto和Cyto相互作用的理解 与分子遗传标记和流行病学风险因素有关 肺癌的病因和理解遗传易感性 通过化学治疗诱导。