ULTRA PORTABLE LOW COST CARDIAC CAMERA

超便携低成本心脏摄像机

• 批准号: 2029214
• 负责人: JEFFREY L LACY
• 金额: $ 24.73万
• 依托单位: PROPORTIONAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2029214
• 关键词: angiography; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; computer program /software; gamma radiation; human subject; personal computers; radionuclides; scintillation cameras; tantalum; tungsten

Nuclear angiography is considered the superior technique for accurate quantitative measurement of ventricular function. Despite this, a growing and predominant fraction of such measurements are performed via echocardiography. Two factors have strongly influenced this shift to a less than optimal technology; 1) the higher equipment costs, and 2) much larger size and lack of portability of the nuclear camera. Proportional Technologies, Inc., proposes to develop an ultra-portable low cost nuclear angiography camera based upon the multiwire proportional camera and 178/Ta generator produced radiopharmaceutical whose cost and portability are directly competitive with echo devices. The camera will incorporate a powerful removable computer with color graphic display and a high speed multiwire sensor. Bedside production of radiopharmaceutical will be provided by an onboard 178/W/178/Ta computer controlled generator equipped with integral dose calibration. In Phase I a prototype camera was successfully produced and thoroughly tested at the Philadelphia Heart Institute. The camera was judged very operationally effective and performed flawlessly in this study. In Phase II six preproduction cameras will be constructed and evaluated in a broad clinical trial combining basic validation of ventricular function measurements required for FDA approval and investigating multiple unique applications offered by the technology. PROPOSED COMMERCIAL APPLICATION: The goal of this project is development of a nuclear angiography camera with substantially lowered cost and improved portability. If successfully developed, this product would facilitate wider usage of the well established and more quantitative nuclear angiography procedure in diagnosis and evaluation of coronary disease, particularly in the critically ill patient. Owing to the sizable patient population undergoing cardiac diagnostic procedure, the market for such a device should be sizable.

核血管造影被认为是准确的优质技术 心室功能的定量测量。 尽管如此，增长 并通过此类测量的主要部分进行 超声心动图。 两个因素强烈影响了这一转变 小于最佳技术； 1）设备成本较高，2） 大小和缺乏核摄像头的便携性。 比例 Technologies，Inc。提议开发超容易发生的低成本核 基于多线比例摄像机和178/TA的血管造影摄像机 发电机生产的放射性药物的成本和便携性是 与Echo设备直接竞争。 相机将包含一个 功能强大的可移动计算机，带有颜色图形显示和高速 多线传感器。 放射药的床边生产将是 由配备的板载178/W/W/178/TA计算机控制的发电机提供 具有整体剂量校准。 在第一阶段，原型相机是 在费城的心脏成功生产和彻底测试 研究所。 摄像机在操作上的判断非常有效，并且 在这项研究中表现完美。 在II阶段六摄影相机 将在一项广泛的临床试验中构建和评估 FDA所需的心室功能测量的基本验证 批准并调查了由 技术。 拟议的商业应用：该项目的目标是开发 核血管造影摄像机的成本大大降低， 提高可移植性。 如果成功开发，该产品将 促进更广泛且更具定量性的更广泛使用 冠状动脉诊断和评估中的核血管造影程序 疾病，特别是在重症患者中。 由于很大 接受心脏诊断程序的患者群体， 这样的设备应该很大。