GENE TESTS FOR COLON CANCER RISK--PSYCHOSOCIAL STUDIES

结肠癌风险的基因测试——社会心理研究

• 批准号: 2209506
• 负责人: GLORIA M. PETERSEN
• 金额: $ 28.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2209506
• 关键词: African American; attitude; cancer risk; caucasian American; colon neoplasms; coping; data collection; family genetics; genetic counseling; genetic disorder diagnosis; health surveys; human subject; interview; neoplasm /cancer genetics; questionnaires; racial /ethnic difference; social psychology; African American; attitude; cancer risk; caucasian American; colon neoplasms; coping; data collection; family genetics; genetic counseling; genetic disorder diagnosis; health surveys; human subject; interview; neoplasm /cancer genetics; questionnaires; racial /ethnic difference; social psychology

The main goal of this proposal is to develop appropriate comprehensive counseling guidelines for predictive colon cancer gene testing by: (1) assessing perceptions and attitudes toward the gene tests, including their social and psychological determinants, and (2) assessing the impact of the test on at-risk persons. Our specific aims are: 1. To characterize in at-risk individuals those psychosocial factors that predict willingness to undergo genetic testing for colon cancer, to determine projected uses that will be made of the gene test, and to determine the influence of social context, primarily family culture, in shaping at-risk individuals' attitudes toward and perceptions of the gene test. This will be accomplished by a mail survey of 1,000 adults at risk for colon cancer. 2. To compare attitudes toward and perceptions of genetic testing for colon cancer between white and African-American individuals (and a subsample of their families). This will be accomplished with the mail survey data and by qualitative telephone interviews with members of 50 families (25 white, 25 African-American) sampled from the mail survey. 3. To identify predictors of psychological distress associated with pre- and post-disclosure cancer risk perception based on: experiences with cancer, knowledge/beliefs/feelings about cancer, implicit models of illness regarding cancer, cancer risk perceptions, coping behaviors, and tolerance for ambiguity. We will offer MSH2 and MLH1 gene tests to 200 individuals at high risk for colon cancer, based on family history. Data will be collected by questionnaire and interviews before and after gene testing (at one month, six months, and one year post disclosure). The gene test will result in one of three possible outcomes: definite gene- positive, definite gene-negative, and inconclusive gene-negative. The first two outcomes are expected when the mutation in the family is known; the last outcome may occur when the mutation is not known, but the family history is strongly suggestive of hereditary colon cancer. We will stratify on the three outcomes and compare pre- and post disclosure measures of distress and attitudes. 4. To assess post disclosure prevention-oriented health behaviors among persons receiving gene positive, gene negative and inconclusive test results. Because screening recommendations may vary with age, we will stratify our analyses by age groups as well as gene test outcome.

该提案的主要目标是开发适当的综合 预测性结肠癌基因测试指南：（1） 评估对基因测试的看法和态度，包括 社会和心理决定因素，以及（2）评估 对高危人士进行测试。我们的具体目的是： 1。要在风险中表征那些心理社会因素 预测对结肠癌进行基因检测的意愿， 确定将由基因测试制成的投影用途，然后 确定社会背景的影响，主要是家庭文化， 塑造高危个人对基因的态度和看法 测试。这将通过对1000名处于危险的成年人的邮件调查来完成 结肠癌。 2。比较对基因检测的态度和看法 白人和非裔美国人之间的结肠癌（以及 家人的子样本）。这将通过邮件完成 调查数据以及通过定性电话访谈与50位成员 从邮件调查中取样的家庭（25名白人，25名非裔美国人）。 3。确定与前相关的心理困扰的预测因素 基于： 癌症，知识/信念/对癌症的感觉，隐性模型 关于癌症，癌症风险感知，应对行为和 对歧义的容忍度。我们将提供MSH2和MLH1基因测试200 基于家族史，患有结肠癌高风险的人。数据 将通过问卷调查和吉恩之后的访谈收集 测试（披露后一个月，六个月和一年）。基因 测试将导致三个可能的结果之一：确定的基因 - 阳性，确定的基因阴性和不确定的基因阴性。这 当家族突变已知时，预计会有前两个结果。 当突变不知道，但家庭可能会发生最后的结果 历史强烈暗示了遗传性结肠癌。我们将 对三个结果进行分层并比较披露前后 苦难和态度的衡量标准。 4.评估预防后披露的预防健康行为 接受基因阳性，基因阴性和尚无定论测试的人 结果。由于筛查建议可能随着年龄的增长而变化，我们将 按年龄组以及基因测试结果对我们的分析进行分层。