DEVELOPMENT AND EVALUATION OF AN ARTIFICIAL HEART

人工心脏的开发和评估

• 批准号: 2215343
• 负责人: GERSON ROSENBERG
• 金额: $ 87.24万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-03-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2215343
• 关键词: DEVELOPMENT; EVALUATION; ARTIFICIAL; HEART

Our interdisciplinary group at The Pennsylvania State University has developed a pneumatic artificial heart. The heart is FDA approved for, and has had limited use as, a bridge to cardiac transplantation. Issues regarding clinical use center around potential for hemolysis (not problematic in calf studies), optimal valves (Bjork-Shiley convexo- concave values are no longer available), thrombus that forms at the suture line between the natural atrium and the atrial cuff, and pump size (for smaller patients). We propose to evaluate hemolysis mechanisms, and alternate prosthetic valves and to compare atrial cuff materials. We recently completed the design and fabrication of a clinical heart for use in smaller patients. We propose to perform appropriate animal implant studies to evaluate this heart. Satisfactory completion of this phase of the research will reduce blood damage and reduce the risk of thromboembolism associated with the artificial heart and will provide a second size artificial heart to encompass a broader range of patients. Also included in the proposed work scope is a protocol for the continued clinical use of the artificial heart as a bridge for transplantation in appropriately selected patients (1 patient/year). Spectacular progress is being made in the electric heart being developed through this grant. Recent animal survival has been extended to 13 months with minimal device wear observed. We now propose a series of logical advances to achieve a system that will be optimal for clinical use (i.e. - implanted electronics, implantable battery, a minimal diffusion compliance chamber, wireless electrical energy transmission via inductive coupling and wireless transmission of messages to and from the heart). The use of hybrid bearings for increased life and performance will be evaluated. Motor Hall sensors will be relocated to reduce device size and ease assembly. Control system enhancements to reduce power consumption and eliminate Hall sensors entirely will be investigated. Engineering studies include bench testing, fluid mechanics, and reliability testing. Chronic animal implant studies, using the well- understood, reliable bovine model, will include detailed hematologic evaluation, and control system evaluation during rest, exercise and pharmacologic intervention. Satisfactory completion of this project will result in a useful artificial heart having a two year functional life, which will be a useful therapeutic tool in certain patients with end- stage heart disease who are not able to have heart transplantation.

我们在宾夕法尼亚州立大学的跨学科小组 开发了气动人造心脏。 心脏是FDA批准的， 并且使用有限的AS是心脏移植的桥梁。 问题 关于临床使用的中心围绕溶血的潜力（不是 小牛研究中有问题），最佳瓣膜（Bjork-Shiley convexo- 凹值不再可用），在形成在 天然心房和心房袖口之间的缝合线和泵尺寸 （适用于较小的患者）。 我们建议评估溶血机制，并 替代假肢和比较心房袖口材料。 我们 最近完成了临床心脏的设计和制造 在较小的患者中。 我们建议执行适当的动物植入物 研究以评估这一心脏。 令人满意的完成阶段 这项研究将减少血液损害，并降低 与人造心脏相关的血栓栓塞，将提供 第二尺寸的人造心脏涵盖了更广泛的患者。 拟议的工作范围中还包括一个协议 人造心脏作为移植的临床用途 适当选择的患者（1名患者/年）。 正在发展的电力心脏正在取得壮观的进步 通过这笔赠款。 最近的动物生存已延长至13 几个月的设备磨损几个月。 我们现在提出了一系列 实现最佳临床系统的逻辑进步 使用（即 - 植入电子产品，可植入电池，最小 扩散合规室，无线电能传输通过 传感耦合和无线传输消息往返于 心）。 使用混合轴承来提高寿命和性能 将进行评估。 车厅传感器将被重新定位以降低设备 尺寸和轻松组装。 控制系统增强功能以​​降低功率 将对消费和消除霍尔传感器进行完全研究。 工程研究包括基准测试，流体力学和 可靠性测试。 慢性动物植入物研究，使用 理解，可靠的牛模型将包括详细的血液学 评估和控制系统评估在休息，锻炼和 药理干预。 令人满意的完成该项目将 导致有用的人造心脏具有两年的功能寿命， 对于某些末端患者，这将是有用的治疗工具 无法进行心脏移植的阶段心脏病。

项目成果

A roller screw drive for implantable blood pumps.

用于植入式血泵的滚柱丝杠驱动装置。

• 发表时间: 1982
• 期刊: Transactions - American Society for Artificial Internal Organs
• 作者: Rosenberg,G;Snyder,A;Weiss,W;Landis,D;Geselowitz,D;Pierce,W
• 通讯作者: Pierce,W

An in vitro evaluation of an artificial heart.

人工心脏的体外评估。

• DOI: 10.1097/00002480-199101000-00009
• 发表时间: 1991
• 期刊: ASAIO transactions
• 作者: Jarvis,P;Tarbell,JM;Frangos,JA
• 通讯作者: Frangos,JA

An electrically powered total artificial heart. Over 1 year survival in the calf.

电动全人工心脏。

• DOI: 10.1097/00002480-199207000-00130
• 发表时间: 1992
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Snyder,AJ;Rosenberg,G;Reibson,J;Donachy,JH;Prophet,GA;Arenas,J;Daily,B;McGary,S;Kawaguchi,O;Quinn,R
• 通讯作者: Quinn,R

The artificial heart--1986: partial fulfillment of a promise.

人造心脏——1986年：部分兑现承诺。

• 发表时间: 1986
• 期刊: ASAIO transactions
• 作者: Pierce,WS

Approaches to the artificial heart. Invited speaker.

接近人造心脏。

• 发表时间: 1981
• 期刊: Surgery
• 影响因子: 3.8
• 作者: Pierce,WS;Myers,JL;Donachy,JH;Rosenberg,G;Landis,DL;Prophet,GA;Snyder,AJ
• 通讯作者: Snyder,AJ