DIFFERENTIATION OF SEXUAL BEHAVIOR

性行为的分化

• 批准号: 2198168
• 负责人: MICHAEL Jay BAUM
• 金额: $ 16.33万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-02-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2198168
• 关键词: animal developmental psychology; autoradiography; brain mapping; cortisol; developmental neurobiology; estradiol; estrogen receptors; estrogens; experimental brain lesion; female; ferrets; glia; gonadotropin releasing factor; hormone regulation /control mechanism; hypothalamus; hysterectomy; immunocytochemistry; luteinizing hormone; male; male castration; maternal behavior; neuroendocrine system; neurons; parent offspring interaction; peer group; perinatal; preoptic areas; prosencephalon; protooncogene; sex behavior; sex differentiation; social behavior; stimulus /response; testosterone; tritium

The possible interaction between early postnatal social stimulation, derived from peers as well as the mother, and the action of testosterone in controlling the sexual differentiation of patterns of sex partner preference, sexual motivation, and coital performance will be assessed in a carnivore, the ferret. The incidence of maternal licking of the genital region of male versus female ferret kits will be studied, and the possible consequences for the neonatal secretion of testosterone in the two sexes will be assessed. These experiments should show whether early social factors can enhance testosterone secretion in males during neonatal life when this steroid is known to promote the completion of behavioral sexual differentiation in this sex. The effects of neurotoxic lesions of a sexually dimorphic male nucleus of the preoptic/anterior hypothalamic area (Mn-POA/AH) on both the development and adult expression of sex partner preference as well as motivational and performance aspects of psychosexual function will be studied in male ferrets. Also, the ability of coital stimulation to activate the expression of the proto-oncogene, c-fos, in gonaldotropin-releasing-hormone containing (GnRH) neurons as well as in non-GnRH neurons of the dorsal POA/AH and other forebrain regions will be compared in male and female ferrets using immunocytochemistry. These studies should help establish the functional significance of this sexually dimorphic structure. Finally, the ontogeny of estradiol receptors in the POA/AH and other brain regions as well as the migration of neurons along the processes of radial glial cells into the POA/AH will be compared in fetal male and female ferrets using auto-radiographic and immunocytochemical methods. The ability of prenatal steroid manipulations to alter these events will also be studied. These experiments should help establish the mechanism whereby estradiol acts during fetal development to promote the formation of the sexually dimorphic Mn-POA/AH in males. Mechanistic studies of behavioral, neuroendocrine, and neural aspects of sexual differentiation using a higher mammalian model, the ferret, should provide insight into these processes in man.

早期产后社会刺激之间的可能相互作用， 源自同龄人和母亲，睾丸激素在 控制性伴侣模式的性差异化 偏好，性动机和同性表现将在评估中进行评估 食肉动物，雪貂。 生殖器舔的发生率 将研究雄性与雌性雪貂套件的区域，并可能 两性中睾丸激素的新生儿分泌的后果 将被评估。 这些实验应该表明早期社交是否 因素可以增强新生儿生活中男性的睾丸激素分泌 当知道这种类固醇可以促进行为性的完成时 这种性别的差异。 A的神经毒性病变的作用 上/前下丘脑的性二态雄性核 （mn-poa/ah）性伴侣的发展和成人表达 偏爱以及心理婚姻的动机和表现方面 功能将在雄性雪貂中进行研究。 另外，珍藏的能力 刺激以激活原始癌基因的表达C-fos 含有（GNRH）神经元的促性腺激素释放激素以及中 背poa/ah和其他前脑区域的非gnRH神经元将是 使用免疫细胞化学的男性和雌性雪貂进行比较。 这些 研究应有助于确定该性别的功能意义 双态结构。 最后，雌二醇受体的个体发育 POA/AH和其他大脑区域以及神经元的迁移 将比较径向神经胶质细胞进入POA/AH的过程 胎儿和女性雪貂使用自动射线照相和 免疫细胞化学方法。 产前类固醇操作的能力 更改这些事件也将进行研究。 这些实验应该有所帮助 建立雌二醇在胎儿发育过程中起作用的机制 促进男性中性二态Mn-POA/AH的形成。 行为，神经内分泌和神经方面的机械研究 使用较高的哺乳动物模型的性别分化，雪貂应 在人类中洞悉这些过程。