PSYCHOBIOLOGY OF STRESS IN FAILURE-TO-THRIVE

成长失败的压力心理生物学

• 批准号: 2200328
• 负责人: MARY J WARD
• 金额: $ 29.47万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2200328
• 关键词: behavior test; body height; body weight; child physical development; cortisol; diet; early diagnosis; emotional adjustment; human subject; infant human (0-1 year); interview; longitudinal human study; malnutrition; marriage /marital status; maternal behavior; mother child interaction; nutrition related tag; postnatal growth disorder; preschool child (1-5); psychobiology; psychological adaptation; psychological stressor; questionnaires; saliva; social behavior; social support network; socioeconomics; stress; behavior test; body height; body weight; child physical development; cortisol; diet; early diagnosis; emotional adjustment; human subject; infant human (0-1 year); interview; longitudinal human study; malnutrition; marriage /marital status; maternal behavior; mother child interaction; nutrition related tag; postnatal growth disorder; preschool child (1-5); psychobiology; psychological adaptation; psychological stressor; questionnaires; saliva; social behavior; social support network; socioeconomics; stress

Failure to thrive (FTT) is a disorder of physical growth in which children of previously normal weight fall below standards for age. Although its etiology is unknown, studies indicate that children with FTT and their mothers are subject to a variety of psychosocial stressors. We propose to study FTT as a stress response syndrome, using adrenocortical activity during feeding and play as a biological indicator of the stress response. There are two components of the proposed project: First, a study of social, behavioral, emotional, and adrenocortical functioning in 150 9- to 24-month-old FTTs and 150 normally-growing children from the same age range, and their mothers. For mothers and children, measures will be obtained for (a) environmental factors (demographics, socioeconomic status, life stress, social support, and marital satisfaction); (b) individual maternal and child factors (child emotional expression and temperament; maternal psychiatric disorders); (c) interactional factors (emotional behavior in play and feeding, and attachment); and (d) adrenocortical activity (salivary cortisol). Second, a longitudinal study of individual differences in growth outcome in the FTT group, in which all children with FTT will be followed for one year after intake. At three-month intervals, children will be examined, anthropometric data updated, and parents interviewed about the child's diet. At 6 and 12 months after intake, the environmental, individual, and interactional measures will be repeated. Analyses will focus on (1) group differences between FTTs and normals on measures of behavior, emotional expression, and patterns of adrenocortical activity; (2) associations among behavior, maternal psychopathology, infant attachment and adrenocortical activity; and (3) individual differences among FTTs in the environmental, individual, interactional, and adrenocortical activity, as predictors of growth outcome.

未能蓬勃发展（FTT）是一种身体成长的障碍，儿童 先前正常体重的年龄低于标准范围以下。 虽然它是 病因尚不清楚，研究表明患有FTT及其儿童 母亲受到各种社会心理压力源的约束。 我们建议 使用肾上腺皮质活性研究FTT作为应力反应综合征 在进食和发挥作用中，作为压力反应的生物学指标。 拟议项目有两个组成部分：首先，研究 150 9至的社会，行为，情感和肾上腺皮质功能 24个月大的FTT和150名通常成长的儿童 范围及其母亲。 对于母亲和孩子，措施将是 获得（a）环境因素（人口统计，社会经济地位， 生活压力，社会支持和婚姻满意度）； （b）个人 母亲和儿童因素（儿童情绪表达和气质； 孕产妇精神病）； （c）互动因素（情感 游戏和喂食以及依恋的行为）； （d）肾上腺皮质 活性（唾液皮质醇）。 其次，对生长结果个体差异的纵向研究 FTT小组，其中所有有FTT的儿童将遵循一年 进气。 在三个月的间隔中，将检查儿童， 人体测量数据已更新，父母对孩子的采访 饮食。 在摄入后的6和12个月后，环境，个人和 将重复进行互动措施。 分析将重点介绍（1）FTT和正态之间的组差异 肾上腺皮质的行为，情绪表达和模式的度量 活动; （2）行为，孕产妇心理病理学，婴儿之间的关联 附着和肾上腺皮质活性； （3）个体差异 在环境，个人，互动和 肾上腺皮质活性，作为增长结果的预测指标。