Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults

太极拳对减缓老年人认知衰退的功效

基本信息

批准号：
10364668
负责人：
FUZHONG LI
金额：
$ 78.72万
依托单位：
OREGON RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10364668
关键词：
Activities of Daily Living Address Adopted Adult Age-associated memory impairment Aging Alzheimer&apos s Disease American Behavior Therapy Caring Clinical Cognition Cognitive Communities Community Practice Data Dementia Development Diagnosis Disease Progression Educational Intervention Elderly Epidemiology Evidence based program Exercise Foundations Gait Health Health Benefit Health Promotion Healthcare Impaired cognition Impairment Intervention Investigation Knowledge Lead Light Link Mediating Methodology Motor Movement Onset of illness Outcome Outcome Measure Participant Perception Performance Persons Pharmacology Physical Exercise Physical Performance Physical activity Play Process Protocols documentation Public Health Randomized Research Research Design Risk Role Self Efficacy Single-Blind Study Solid Stretching Tai Ji Testing Therapeutic Training Work active control amnestic mild cognitive impairment arm base brain health care burden clinical practice cognitive enhancement cognitive function cognitive training community setting control trial cost cost effective design disorder prevention effective intervention executive function exercise intervention exercise training follow-up health practice health related quality of life high risk human old age (65+)improved mild cognitive impairment multitask novel post intervention preservation prevent primary outcome prospective protective effect secondary outcome therapeutically effective

项目摘要

Project Summary/Abstract Background. Exercise is generally considered a non-pharmacological strategy that plays an important protective role in preserving cognitive function or mitigating the progression of cognitive impairment for older adults with mild cognitive impairment (MCI). Most exercise interventions, however, focus exclusively on physical development. Relatively few interventions have either combined physical and cognitive training concomitantly or explicitly integrated cognitive-physical components for cognitive stimulation. Moreover, the evidence that exercise improves cognitive function in older adults with MCI is both limited and inconclusive, making it difficult to recommend best practices. Objective. The primary objective of this application is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health (TJQMMBH). TJQMMBH is built on a comprehensively researched, evidence-based program that has been shown to have multiple health outcomes but now explicitly integrates a cognitive component aimed at increasing multitasking costs and cognitive demands on performing deliberate daily motor tasks. Accordingly, grounded on our promising pilot data, our primary aim in this proposed study is to determine whether the newly developed TJQMMBH intervention will have a positive effect on cognitive function in older adults with amnestic MCI. We also have four secondary aims that will examine whether (1) TJQMMBH can slow the progression of cognitive impairment; (2) improvement in global cognitive function is mediated through gains in movement confidence; (3) the benefits of the TJQMMBH intervention on cognitive outcomes persist over a post-intervention follow-up period; and (4) there is an association between change in executive function and physical performance. Approach. Our core approach to achieving our research aims is to perform a prospective, single-blind, 3-arm, randomized (active control) trial in which the cognitively enhanced TJQMMBH intervention will be evaluated against a standard Tai Ji Quan intervention and a stretching exercise control. Our design will allow us to test the hypothesis regarding the efficacy of a 6-month TJQMMBH intervention, relative to standard Tai Ji Quan and stretching control, in improving the primary outcomes of global cognitive function and motor-cognitive dual- task gait performance and the secondary outcomes of domain-specific cognitive functions in community- dwelling older adults who have been diagnosed with amnestic MCI per established clinical criteria. Significance and impact. This work is significant because it addresses the currently limited options in community and clinical practice for offering the most effective strategies that address cognitive decline in older adults with MCI. Therefore, if the proposed intervention proves to be effective, the scientific impact is likely to be high in terms of providing an alternative, non-pharmacological-based cognitive training intervention to ameliorate cognitive decline in older Americans with MCI and delay or prevent the onset of dementia.

项目概要/摘要背景。运动通常被认为是一种非药物策略，具有重要的作用在保持老年人认知功能或减轻认知障碍进展方面发挥保护作用患有轻度认知障碍（MCI）的成年人。然而，大多数运动干预措施只专注于身体发育。相对较少的干预措施结合了身体和认知训练伴随或明确地整合认知物理成分以进行认知刺激。此外，锻炼可以改善患有 MCI 的老年人的认知功能的证据既有限又不确定，使得推荐最佳实践变得困难。客观的。该应用程序的主要目标是确定认知增强的功效运动干预 - 太极拳：保持大脑健康（TJQMMBH）。 TJQMMBH 建立在经过全面研究、基于证据的计划，已被证明具有多种健康成果但现在明确整合了一个认知组件，旨在增加多任务处理成本和认知能力需要执行有意识的日常运动任务。因此，基于我们有希望的试点数据，我们这项拟议研究的主要目的是确定新开发的 TJQMMBH 干预措施是否会对患有遗忘性 MCI 的老年人的认知功能有积极影响。我们还有四所中学目的是检查（1）TJQMMBH 是否可以减缓认知障碍的进展； (2) 整体认知功能的改善是通过运动信心的增强来调节的； (3) 好处 TJQMMBH 对认知结果的干预在干预后的随访期内持续存在；和（4）执行功能的变化和身体表现之间存在关联。方法。我们实现研究目标的核心方法是进行前瞻性、单盲、三臂、将评估认知增强 TJQMMBH 干预的随机（主动对照）试验反对标准的太极拳干预和伸展运动控制。我们的设计将使我们能够测试关于 6 个月 TJQMMBH 干预效果相对于标准太极拳的假设和伸展控制，改善整体认知功能和运动认知双重功能的主要结果任务步态表现和社区特定领域认知功能的次要结果根据既定临床标准被诊断患有遗忘性 MCI 的居住老年人。意义和影响。这项工作很重要，因为它解决了当前有限的选择社区和临床实践提供最有效的策略来解决老年人认知能力下降的问题患有 MCI 的成人。因此，如果所提议的干预措施被证明是有效的，其科学影响可能会在提供替代性、非药物性认知训练干预方面表现出色改善患有 MCI 的美国老年人认知能力下降，并延缓或预防痴呆症的发作。