Development of an MRI Template & Neuroimaging Biomarkers of the Pediatric Spinal Cord

MRI 模板的开发

• 批准号: 10352312
• 负责人: Laura Krisa
• 金额: $ 48.95万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10352312
• 关键词: 17 year old; 3-Dimensional; 8 year old; Address; Age; American; Anatomy; Anxiety; Area; Atrophic; Biological; Biological Markers; Cervical; Chest; Child; Childhood; Childhood Injury; Chronic; Classification; Clinical; Clinical Trials; Communities; Data; Data Set; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Esthesia; Functional Imaging; Future; Image; Imaging Techniques; Impairment; Injury; International; Knowledge; Location; Magnetic Resonance Imaging; Measurement; Measures; Methods; Motor; Nature; Neurites; Neurologic; Neurological status; Patients; Population; Process; Public Health; Recovery; Reference Values; Research; Research Personnel; Resolution; Scanning; Sensitivity and Specificity; Severities; Spinal Cord; Spinal Cord Diseases; Spinal Injuries; Spinal cord injury; Spinal cord injury patients; Standardization; Techniques; Tissues; Treatment Effectiveness; Validation; Work; base; biomarker development; clinical imaging; clinical predictors; density; imaging biomarker; imaging modality; injured; neurodevelopment; neuroimaging; neuroimaging marker; neurological recovery; pediatric patients; predictive modeling; quantitative imaging; relating to nervous system; sex; spinal cord imaging; tool; white matter

The neurological consequence of spinal cord injury (SCI) in children is not fully understood. The inability to accurately assess motor, sensation and extent of injury in the pediatric population raises speculation about diagnoses, recovery potential, and treatment effectiveness. This proposed study builds upon the team's previous work to establish quantitative imaging biomarkers using advanced imaging methods such as diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI) and atrophy estimated through a spinal cord cross sectional area (SCCSA) – in pediatric SCI patients. In the recent years magnetic resonance imaging (MRI) methods such as DTI, DKI, SCCSA measurements, and Neurite Orientation Density Dispersion Imaging (NODDI) have shown promising results as powerful and non-invasive biomarkers to evaluate the spinal cord (SC) in children. To the best of our knowledge, our research team is the only one thus far to apply these imaging techniques to the pediatric population. Although all of these techniques have demonstrated potential for providing microstructural information about the SC, the development and application of objective diffusion- based biomarkers for identifying the precise location of the injured cord has been challenging because neither a standard anatomical template of the pediatric SC nor biological age and sex matched normative values are available. Hence, the first aim of this study is to create a standardized SC imaging template and establish SCCSA measurements of the entire pediatric SC between 6-17 years of age. The second aim of this study will establish normative multishell diffusion imaging values for continuous segments of the cervical-thoracic pediatric SC between 6-17 years of age. This work will result in standardization and consistent interpretation of these neuroimaging metrics and will reduce user variability. A sub aim of this work is to demonstrate the feasibility of these imaging biomarkers in a group of children with chronic motor complete (American Spinal Injury Association Impairment Scale (AIS) A and B) SCI. This work will address a significant knowledge gap by providing functional imaging biomarkers to clinicians and researchers so they can objectively determine the extent of severity and level of injury and develop prediction models in pediatric SCI. This work would also aid clinicians in assessing neurological recovery, and evaluate treatment effectiveness in clinical trials. In addition, these imaging biomarkers and normative templates can be extended to other pediatric SC diseases in the future.

儿童脊髓损伤 (SCI) 的神经后果尚未完全明确。 准确评估儿科人群的运动、感觉和损伤程度引发了关于 这项拟议的研究以团队的研究为基础。 先前使用扩散等先进成像方法建立定量成像生物标志物的工作 张量成像 (DTI)、扩散峰度成像 (DKI) 和通过脊髓交叉估计的萎缩 截面积 (SCCSA) – 近年来在儿科 SCI 患者中使用磁共振成像 (MRI)。 DTI、DKI、SCCSA 测量和神经突取向密度色散成像等方法 （NODDI）作为评估脊髓的强大且非侵入性生物标志物已显示出有希望的结果 据我们所知，我们的研究团队是迄今为止唯一应用这些的团队。 尽管所有这些技术都已被证明具有潜力。 提供有关 SC 的微观结构信息、客观扩散的开发和应用- 基于生物标记物来识别受伤脊髓的精确位置一直具有挑战性，因为两者都没有 儿科 SC 的标准解剖模板也没有生物学年龄和性别匹配的规范值 因此，本研究的首要目标是创建标准化的 SC 成像模板并建立。 SCCSA 对 6-17 岁儿童的整个 SC 进行测量 本研究的第二个目标是。 建立颈胸椎连续节段的规范多壳扩散成像值 这项工作将导致 6-17 岁儿童 SC 的标准化和一致解释。 这些神经影像指标将减少用户的变异性。这项工作的一个子目标是展示 这些成像生物标志物在一组慢性运动完全性儿童中的可行性（美国脊柱 伤害协会损伤量表 (AIS) A 和 B) SCI 这项工作将通过以下方式解决重大知识差距。 为忠诚者和研究人员提供功能成像生物标志物，以便他们能够客观地确定 这项工作也有助于确定损伤的严重程度和程度，并开发儿科 SCI 的预测模型。 马在临床试验中评估神经恢复情况和治疗效果。 这些成像生物标志物和规范模板可以扩展到其他儿科 SC 疾病 未来。