Predictors of Momentary Smoking Lapse Among African American Menthol Cigarette Smokers

非洲裔美国薄荷醇卷烟吸烟者短暂戒烟的预测因素

基本信息

批准号：
10351234
负责人：
Dina Marie Jones
金额：
$ 16.05万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10351234
关键词：
Abstinence Affect African American African American population Behavior Therapy Behavioral trial Biochemical Black race Carbon Monoxide Cessation of life Cigarette Cigarette Smoker Competence Consumption Data Dependence Development Plans Ecological momentary assessment Electronic cigarette Ethnic Origin Exhalation Goals Health Health Disparities Research Intervention Interview K-Series Research Career Programs Literature Malignant Neoplasms Mediating Menthol Mentorship Moods Morbidity - disease rate Nicotine Nicotine Dependence Observational Study Participant Predictive Factor Race Randomized Relapse Research Research Personnel Role Science Scientist Smoke Smoker Smoking Smoking Prevention Smoking Status Surveys Technology Testing Time Tobacco Training aged base career career development cigarette smoke cigarette smoking contextual factors efficacy testing electronic cigarette use experience follow-up mHealth mobile application negative affect nicotine craving novel perceived discrimination perceived stress positive mood prevent primary outcome recruit secondary outcome smoking cessation smoking relapse social disadvantage statistics success summer institute tobacco regulatory science

项目摘要

PROJECT SUMMARY Black cigarette smokers, 85% of whom smoke menthol cigarettes, suffer excess tobacco-caused morbidity and death, including cancer. Menthol (v. non-menthol) cigarette smokers, especially Black smokers, have a greater dependence on nicotine and are less likely to quit smoking, despite having more quit attempts. This may be partly due to greater abstinence-induced declines in positive mood/affect and nicotine cravings. However, there are limited data on the underlying mechanisms that explain smoking lapses among Black menthol smokers. Prior studies have used ecological momentary assessment (EMA) to examine how negative affect (i.e., poor mood), nicotine craving (i.e., urge to smoke), and contextual factors predict cigarette smoking lapse in real- time. Understanding these underlying mechanisms will help us develop effective cessation interventions for Black menthol smokers. To fill these critical research gaps, this study will use EMA to 1) examine the within- subject association between momentary negative affect, nicotine craving, and smoking lapse (aim 1) and 2) examine momentary perceived stress and discrimination as moderators of the momentary affect, nicotine craving, and smoking lapse relationship (aim 2) among Black menthol cigarette smokers who do and do not use e-cigarettes. Our central hypothesis is that, at the within-subjects level, higher levels of negative affect than usual will be associated with stronger nicotine cravings, and in turn predict momentary smoking lapse (any v. no smoking) among Black menthol cigarette smokers during a quit attempt. We will recruit 150 Black Arkansan menthol cigarette smokers aged 21-64 who plan to quit smoking in the next 30 days (n=100 cigarette only smokers; n=50 cigarette-e-cigarette dual users) to test our hypothesis on the primary outcome momentary of smoking lapse (any v no smoking). Secondary outcomes include time to smoking lapse, time to smoking relapse, and cigarette consumption. We will also conduct exploratory between-subject analyses by e-cigarette use status. Participants will complete a baseline 7-day pre-quit EMA wave and 7-day post-quit EMA wave, as well as baseline, 1 month, 3-month, and 6-month follow-up online surveys. Smoking status will be verified using exhaled carbon monoxide. This study will fill literary gaps on momentary predictors of smoking lapses among Black menthol smokers and will provide preliminary data for an R01 application. The PI has assembled an outstanding mentorship team who will guide her rigorous training and career development plans. Through formal coursework, summer institutes, hands-on training, and external trainings the PI will increase her competency in EMA/mHealth, randomized behavioral trials, advanced statistics, and tobacco disparities and regulatory science research. Receipt of this K award will strengthen the PI's likelihood of achieving her career goal to become an independent researcher and conduct technology-supported observational studies and interventions that aim to increase successful smoking cessation among socially-disadvantaged smokers.

项目概要黑人吸烟者（其中 85% 吸薄荷醇卷烟）因烟草引起的发病率过高，并且死亡，包括癌症。薄荷醇（与非薄荷醇）吸烟者，尤其是黑人吸烟者，有更大的尽管有更多的戒烟尝试，但对尼古丁的依赖并且戒烟的可能性较小。这可能是部分原因是戒烟引起的积极情绪/情感和尼古丁渴望的大幅下降。然而，有关于解释黑人薄荷醇吸烟者吸烟失误的根本机制的数据有限。先前的研究已经使用生态瞬时评估（EMA）来检查负面影响（即不良影响）情绪）、尼古丁渴望（即吸烟的冲动）和情境因素可以预测真实的吸烟衰退。时间。了解这些潜在机制将有助于我们制定有效的戒烟干预措施黑色薄荷醇吸烟者。为了填补这些关键的研究空白，本研究将使用 EMA 来 1）检查内部 - 短暂负面情绪、尼古丁渴望和戒烟之间的受试者关联（目标 1）和 2）检查瞬时感知的压力和歧视作为瞬时影响的调节剂，尼古丁吸烟和不吸烟的黑人薄荷醇卷烟者的渴望和戒烟关系（目标 2）使用电子烟。我们的中心假设是，在受试者内部水平上，负面情绪水平较高比平时更强烈的尼古丁渴望，进而预测短暂的戒烟（任何与不吸烟）黑人薄荷醇香烟吸烟者在尝试戒烟期间。我们将招募150名黑人阿肯色州 21-64 岁计划在未来 30 天内戒烟的薄荷醇卷烟吸烟者（n=100 支香烟）仅吸烟者； n=50 名香烟-电子烟双重使用者）来检验我们对主要结果瞬时的假设戒烟（任何戒烟）。次要结果包括戒烟时间、戒烟时间复发和吸烟。我们还将通过电子烟进行探索性受试者间分析使用状态。参与者将完成基线 7 天退出前 EMA 波和 7 天退出后 EMA 波，如下以及基线、1 个月、3 个月和 6 个月的后续在线调查。将验证吸烟状况使用呼出的一氧化碳。这项研究将填补吸烟失误瞬时预测因素的文献空白在黑人薄荷醇吸烟者中进行研究，并将为 R01 应用提供初步数据。 PI已集结优秀的导师团队将指导她严格的培训和职业发展计划。通过正式课程、暑期学院、实践培训和外部培训，PI 将提高她的能力 EMA/mHealth、随机行为试验、高级统计和烟草差异方面的能力监管科学研究。获得 K 奖将增强 PI 实现职业生涯的可能性目标是成为一名独立研究人员并进行技术支持的观察性研究和旨在提高社会弱势吸烟者成功戒烟的干预措施。