7T MRI as a potential tool for detection of pathology in Alzheimer's disease
7T MRI 作为检测阿尔茨海默病病理的潜在工具
基本信息
- 批准号:10349883
- 负责人:
- 金额:$ 10.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer&aposs disease patientAmyloidAmyloid beta-ProteinAmyloid beta-Protein PrecursorAnatomyApplications GrantsAutopsyBiologicalBiological MarkersBrainBrain regionBudgetsClinicalCommunitiesContractsControl GroupsDataData ReportingDepositionDetectionDevelopmentDiagnosisDiseaseDisease MarkerDisease ProgressionEarly DiagnosisEducational process of instructingExposure toFunctional disorderGoalsHomeostasisHumanImageImaging TechniquesImpairmentIndividualInvestigationIronKnowledgeMagnetic Resonance ImagingMagnetismMeasurementMeasuresMentorshipMethodsMicroscopicMicroscopyNerve DegenerationNeurofibrillary TanglesNeurosciencesNeurosciences ResearchNoiseNormal tissue morphologyOnset of illnessOutcomeOxidation-ReductionPathologicPathologyPatientsPatternPerformancePlayPositron-Emission TomographyPredispositionProductionProfessional CompetencePropertyProteinsProtocols documentationRadiationResearchResearch Project GrantsResolutionRoleScanningScientistSenile PlaquesSignal TransductionSourceTechniquesTestingTimeTissuesTrainingVariantVisualizationWorkabeta accumulationbasecareercareer developmentclinical diagnosiscohortdesigndiagnostic tooldisease prognosisdisease prognosticelectron densityexperiencehealthy volunteerimprovedin vivoinsightinterestlecturesmagnetic fieldnervous system disorderneuroimagingneuropathologynovelpre-clinicalradio frequencyradiotracerrecruitsexsymposiumtissue mappingtoolultra high resolutionvolunteer
项目摘要
Project Summary/Abstract
Amyloid-beta (Aβ) is a small piece of a larger protein called amyloid precursor protein. It accumulates in
stages into microscopic amyloid plaques that are considered a hallmark of a brain affected by Alzheimer’s
disease (AD). Positron emission tomography (PET) is an established technique to detect Aβ plaques in vivo.
Some preclinical and postmortem data report an accumulation of redox-active iron near Aβ plaques.
magnetic resonance imaging (MRI) of Aβ plaques has been attempted using various techniques, notably
with susceptibility contrast. The non-invasive detectability of Aβ plaques in MRI has so far been largely
attributed to iron deposition accompanying Aβ plaques. It is believed that the susceptibility shortening
effects of paramagnetic iron are the primary source of contrast between plaques and surrounding tissue. We
hypothesized that aggregations of iron associated Aβ would increase electron density and induce notable
changes in local susceptibility value. Due to higher susceptibility at ultra-high field (UHF) strengths, induced
iron susceptibility is large enough to generate contrast relative to surrounding normal tissues that can be
visualized by quantitative susceptibility techniques at 7 Tesla (7T) MRI.
The goal of this proposal is to bring forward an alternative platform for analysis of pathologic
biomarkers in AD patients, thanks to ultrahigh field (7T) MR neuroimaging. The development of
specialized sequences for 7T susceptibility MRI will enable the comparison and microstructural data in AD
patients at an unprecedented resolution; this, in turn, will provide a deeper understanding of the in vivo
pathophysiology of AD and allow us to potentially identify a set of susceptibility-based markers of disease
pathology. Specifically, we expect our integrated approach to help us validate UHF MRI as a unique tool to
improve AD diagnosis and prognostic measurements. Our central hypothesis is that UHF MRI provides a
unique and powerful measure of changes associated with AD in the brain, and may be integrated with
existing neuroimaging tools to achieve unprecedented visualization of the consequences of disease
pathology.
This career development project also includes a training plan designed to refine and address gaps in the
applicant’s technical and scientific knowledge and experience, develop his research career skills, expose
him to the neuroimaging and neuroscience communities, and lay the groundwork for his career as an
independent scientist. The training plan encompasses: coursework in neurological disorders, clinical
neuroscience, research grant applications, and budget management; presentation of his work at technical
MRI and neuroscience conferences; delivery of formal classroom lectures and small-group teaching
sessions; mentorship of research volunteers; organizing a research symposium; and hands-on training
during the conduct of the research project.
项目概要/摘要
β 淀粉样蛋白 (Aβ) 是一种称为淀粉样前体蛋白的较大蛋白质的一小部分,它积聚在其中。
阶段为微小的淀粉样蛋白斑块,这被认为是受阿尔茨海默病影响的大脑的标志
正电子发射断层扫描 (PET) 是一种体内检测 Aβ 斑块的成熟技术。
一些临床前和尸检数据报告了 Aβ 斑块附近氧化还原活性铁的积累。
已经尝试使用各种技术对 Aβ 斑块进行磁共振成像 (MRI),特别是
迄今为止,MRI 中 Aβ 斑块的无创检测能力已基本实现。
据认为,这是由于伴随 Aβ 斑块的铁沉积所致。
顺磁性铁的作用是斑块和周围组织之间对比的主要来源。
提出铁相关 Aβ 的聚集会增加电子密度并引起显着的
由于超高场 (UHF) 强度下的磁化率较高,导致局部磁化率值发生变化。
铁磁化率足够大,可以产生相对于周围正常组织的对比度
通过 7 特斯拉 (7T) MRI 的定量磁化率技术可视化。
该提案的目标是提出一个用于病理分析的替代平台
AD 患者的生物标志物,得益于超高场 (7T) MR 神经影像学的发展。
7T 磁化率 MRI 的专用序列将使 AD 中的比较和微观结构数据成为可能
患者以前所未有的分辨率;这反过来又将提供对体内的更深入的了解。
AD 的病理生理学,使我们能够潜在地识别一组基于易感性的疾病标志物
具体来说,我们希望我们的综合方法能够帮助我们验证 UHF MRI 作为一种独特的工具。
改善 AD 诊断和预后测量 我们的中心假设是 UHF MRI 提供了一种方法。
与 AD 相关的大脑变化的独特而强大的测量方法,并且可以与
现有的神经影像工具可以实现疾病后果的前所未有的可视化
病理。
该职业发展项目还包括旨在完善和解决职业发展差距的培训计划。
申请人的技术和科学知识和经验,发展他的研究职业技能,暴露
他进入了神经影像学和神经科学界,并为他的职业生涯奠定了基础
独立科学家的培训计划包括:神经系统疾病、临床课程。
神经科学、研究资助申请和预算管理的技术工作介绍;
MRI 和神经科学会议;提供正式的课堂讲座和小组教学
会议;对研究志愿者的指导;组织研究研讨会和实践培训;
在研究项目进行期间。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Akbar Alipour其他文献
Akbar Alipour的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Akbar Alipour', 18)}}的其他基金
7T MRI as a potential tool for detection of pathology in Alzheimer's disease
7T MRI 作为检测阿尔茨海默病病理的潜在工具
- 批准号:
10704500 - 财政年份:2022
- 资助金额:
$ 10.69万 - 项目类别:
7T MRI as a potential tool for detection of pathology in Alzheimer's disease
7T MRI 作为检测阿尔茨海默病病理的潜在工具
- 批准号:
10704500 - 财政年份:2022
- 资助金额:
$ 10.69万 - 项目类别:
相似国自然基金
多氯联苯与机体交互作用对生物学年龄的影响及在衰老中的作用机制
- 批准号:82373667
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
基于年龄和空间的非随机混合对性传播感染影响的建模与研究
- 批准号:12301629
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
母传抗体水平和疫苗初种年龄对儿童麻疹特异性抗体动态变化的影响
- 批准号:82304205
- 批准年份:2023
- 资助金额:20 万元
- 项目类别:青年科学基金项目
运动状态下代谢率的年龄变化特征及对人体热舒适的影响研究
- 批准号:
- 批准年份:2022
- 资助金额:54 万元
- 项目类别:面上项目
基于堆叠式集成学习探索人居环境对生物学年龄的影响
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
Executive functions in urban Hispanic/Latino youth: exposure to mixture of arsenic and pesticides during childhood
城市西班牙裔/拉丁裔青年的执行功能:童年时期接触砷和农药的混合物
- 批准号:
10751106 - 财政年份:2024
- 资助金额:
$ 10.69万 - 项目类别:
The Proactive and Reactive Neuromechanics of Instability in Aging and Dementia with Lewy Bodies
衰老和路易体痴呆中不稳定的主动和反应神经力学
- 批准号:
10749539 - 财政年份:2024
- 资助金额:
$ 10.69万 - 项目类别:
Stopping Hydroxychloroquine In Elderly Lupus Disease (SHIELD)
停止使用羟氯喹治疗老年狼疮病 (SHIELD)
- 批准号:
10594743 - 财政年份:2023
- 资助金额:
$ 10.69万 - 项目类别:
Identifying and testing a tailored strategy to achieve equity in blood pressure control in PACT
确定并测试量身定制的策略,以在 PACT 中实现血压控制的公平性
- 批准号:
10538513 - 财政年份:2023
- 资助金额:
$ 10.69万 - 项目类别: