Center for Environmental and Health Effects of PFAS

PFAS 环境与健康影响中心

基本信息

批准号：
10337301
负责人：
CAROLYN J MATTINGLY
金额：
$ 143.9万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337301
关键词：
Address Analytical Chemistry Animal Model Area Biological Biology Cell model Collaborations Communities Community Health Computational Technique Cosmetics Data Analyses Data Science Detection Ensure Environment Environmental Engineering technology Environmental Epidemiology Environmental Exposure Environmental Health Environmental Pollution Environmental Science Epidemiology Evaluation Exposure to Fostering Fright Goals Government Health Human Immune system Immunology Industrial Product Infrastructure Institutes Knowledge Leadership Liver Malignant Neoplasms Manufacturer Name Mus North Carolina Organism Pathway interactions Poison Poly-fluoroalkyl substances Population Prevention Prevention strategy Public Health Research Research Project Grants Research Support Research Training Resistance Resources Risk Scientist Stains Structure Superfund System Technology Thyroid Function Tests Thyroid Gland Toxic effect Toxicology Training Translational Research Trust United States Environmental Protection Agency Universities Water Zebrafish advanced analytics base bioaccumulation chemical property combinatorial community engagement community involvement community partnership consumer product data management data science management data sharing disease registry exposed human population health literacy immune function improved innovation instrumentation next generation programs remediation training opportunity

项目摘要

ABSTRACT Overall Per- and polyfluoroalkyl substances (PFAS) are emerging as a major public health problem in North Carolina (NC) and across the US. PFAS comprise a class of almost 5,000 known compounds. Their unique chemical properties have been harnessed to make consumer and industrial products more water, stain, and grease resistant; they are found in products as diverse as cosmetics and firefighting foams. Despite increasing evidence that they are found ubiquitously in the environment, there is a paucity of knowledge about their toxicity. For the few well-studied PFAS, associated health effects include cancer and toxicity to the liver, thyroid, and immune system; but human exposure levels, mechanisms of action, bioaccumulation, or effective remediation approaches remain unclear for the majority of PFAS. As a result of recent widespread detection in the environment and increasing evidence of human exposure we propose to establish a Superfund Research Program (SRP) Center for Environmental and Human Health Effects of PFAS. Several of these compounds are included on the Substance Priority List of the Agency for Toxic Substances and Disease Registry and are considered contaminants of emerging concern by the US Environmental Protection Agency. The long-term objective of our Center is to advance understanding about PFAS 1) environmental and human exposure in impacted areas, 2) toxicity and underlying mechanisms of thyroid and immune function, 3) bioaccumulation potential, and 4) remediation. To meet our objective we will employ a highly transdisciplinary approach that will integrate leaders in diverse fields (epidemiology, environmental science and engineering, biology, toxicology, immunology, data science, and advanced analytics) across two major NC Universities (NC State and East Carolina Universities); multiple levels of biological organization (biomolecule, pathway, cell, model organisms (periphyton, mayflies, zebrafish, mouse), and human populations); state-of-the-art analytical technologies; cutting-edge data science and management approaches; a recognized track record in interdisciplinary, environmental health science training; and well-established partnerships with government and community stakeholders. We aim to be a trusted resource for SRP stakeholders and impacted communities and to catalyze discovery of information that leads to prevention of PFAS exposure and protection of human health.

抽象的全面的全氟烷基物质和多氟烷基物质 (PFAS) 正在成为北卡罗来纳州的一个主要公共卫生问题（北卡罗来纳州）和美国各地。 PFAS 包含一类近 5,000 种已知化合物。他们独特的化学物质特性已被利用，使消费品和工业产品更加水、污渍和油脂抵抗的;它们存在于化妆品和消防泡沫等多种产品中。尽管增加有证据表明它们在环境中无处不在，但人们对它们的了解却很少毒性。对于少数经过充分研究的 PFAS，相关的健康影响包括癌症以及对肝脏、甲状腺、和免疫系统；但人类接触水平、作用机制、生物蓄积性或有效大多数 PFAS 的修复方法仍不清楚。由于最近广泛检测环境和人类暴露的证据越来越多，我们建议建立一个超级基金研究 PFAS 环境和人类健康影响计划 (SRP) 中心。其中几个化合物被列入有毒物质和疾病管理局的优先物质清单已登记并被美国环境保护局视为新兴关注的污染物。我们中心的长期目标是增进对 PFAS 1) 环境和受影响地区的人类暴露，2) 毒性以及甲状腺和免疫的潜在机制功能，3) 生物蓄积潜力，以及 4) 修复。为了实现我们的目标，我们将聘请高度跨学科方法将整合不同领域（流行病学、环境科学）的领导者以及工程学、生物学、毒理学、免疫学、数据科学和高级分析）跨越两个专业北卡罗来纳大学（北卡罗来纳州立大学和东卡罗来纳大学）；多层次的生物组织（生物分子、通路、细胞、模式生物（附生生物、蜉蝣、斑马鱼、小鼠）和人类人口）；最先进的分析技术；尖端数据科学和管理方法；在跨学科、环境健康科学培训方面拥有公认的记录；和与政府和社区利益相关者建立良好的伙伴关系。我们的目标是成为值得信赖的为 SRP 利益相关者和受影响社区提供资源，并促进发现可引导的信息预防PFAS暴露，保护人类健康。