Project 3 - Ex vivo immune profiling of dengue viruses and vaccines

项目 3 - 登革热病毒和疫苗的离体免疫分析

• 批准号: 10330073
• 负责人: Ana Fernandez-Sesma
• 金额: $ 15.27万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-11 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10330073
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adult; COVID-19 pandemic; Child; Dengue Vaccine; Enrollment; Epidemiology; Funding; Health; Household; Human; Immune; Lung diseases; Monitor; National Institute of Allergy and Infectious Disease; Participant; Pediatric Research; Population; Serology; Surveys; Testing; United States National Institutes of Health; design; epidemiologic data; infection burden; infection rate; member; prospective; research study; response

The COVID-19 pandemic is the most important health challenge to the US population within a century. Most epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults. Inadequate information regarding the infection burden in children is available, especially in the context of households that are prospectively monitored with repetitive testing. This information is critical to determine the silent and symptomatic infection rate in children. The NIAID-supported Human Epidemiology and Response to SARS- CoV-2 (HEROS) survey study is designed to fill this gap.

COVID-19 大流行是美国人民面临的最重要的健康挑战 世纪。大多数流行病学数据都集中在导致严重呼吸道疾病的病例上 该病主要见于成人。关于感染负担的信息不充分 儿童是可以利用的，特别是在未来受到监控的家庭中 通过重复测试。该信息对于确定无症状和有症状的患者至关重要 儿童感染率。 NIAID 支持的人类流行病学和对 SARS 的应对 CoV-2 (HEROS) 调查研究旨在填补这一空白。