Brain-based Mechanisms of Emotion Regulation in Aging and Mood Disorders

衰老和情绪障碍中基于大脑的情绪调节机制

基本信息

批准号：
10319173
负责人：
Katherine Elizabeth Burdick
金额：
$ 82.12万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-15 至 2025-10-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10319173
关键词：
Address Adult Affect Affective Age Aging Amygdaloid structure Attention Attenuated Base of the Brain Behavior Biological Biological Assay Bipolar Disorder Brain Clinical Cognition Cognitive Cognitive deficits Complex Coping Skills Depressive disorder Development Diagnostic Disease remission Elderly Emotional Emotions Enrollment Goals Impairment Intervention Learning Longevity Maintenance Major Depressive Disorder Maps Measures Mediating Memory Mental Depression Mental disorders Mood Disorders Moods National Institute of Mental Health Negative Valence Onset of illness Outcome Patient Self-Report Patients Pattern Performance Personal Satisfaction Play Process Recurrence Relapse Reporting Research Domain Criteria Rest Risk Role Sampling Services Social Functioning Stimulus Strategic Planning Structure Thinking Well in self Work age related aging brain attentional bias base clinically relevant cognitive control critical period emotion regulation emotional experience executive function flexibility functional disability heuristics improved middle age negative affect network dysfunction novel sex social social deficits therapy design therapy resistant trait white matter change

项目摘要

PROJECT SUMMARY Effective emotion regulation (ER) requires the ability to flexibly and dynamically respond to affectively-valenced stimuli in the service of goal-directed behaviors. Patients with major mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD) are characterized by brain-based abnormalities in affective processing and cognitive deficits that make it difficult for them to regulate their emotions. Disruptions in ER are thought to play a role in risk for onset of illness, a relapsing course, and incomplete remission. Aging may amplify poor outcomes in older adults with depression, as reflected in a more severe course and treatment resistance. In contrast, in healthy adults, ER improves across the lifespan with a shift from attending to negative to attending to positive stimuli in attention, learning and memory. Consistent with RDoC, we will leverage multiple units of analysis (circuit, performance, self-report) in a transdiagnostic sample enriched for a range of ER-related network functions, implicit attentional biases, and ER strategies. We will enroll 200 adults (ages 41-80) with an affectively-stable mood disorder (100 BD, 100 MDD), and 100 demographically-matched healthy controls, allowing us to capture the range from extreme positive to extreme negative emotional experience. We will assess performance-based affective biases, cognitive control, and resting-state functional connectivity (FC), to define age-related changes in ER circuitry. We will assay habitual use of ER strategies, social functioning, and well-being to determine how brain-based processes affect these functionally- and clinically-relevant outcomes. Impact. The goals of this project are directly aligned with the NIMH Strategic Plan to develop new ways of characterizing and treating mental illness that are predicated on understanding brain-based mechanisms. Beyond the heuristic value of understanding the specific mechanisms and developmental trajectory of ER in mid and late life, results can be used to inform the development of novel interventions (e.g., neurostimulation, cognitive interventions) designed to “rescue” the specific network dysfunctions that give rise to maladaptive ER in depressive disorders.

项目概要有效的情绪调节（ER）需要能够灵活、动态地响应情感效价为患有重大情绪障碍（包括双相情感障碍）的患者提供刺激。（BD）和重度抑郁症（MDD）的特点是大脑的情感异常导致他们难以调节情绪的处理和认知缺陷是 ER 的障碍。被认为在疾病发作、复发和不完全缓解的风险中发挥作用，并且衰老可能会加剧。患有抑郁症的老年人的预后较差，这反映在更严重的病程和治疗抵抗上。相比之下，在健康成年人中，ER 在整个生命周期中都有所改善，从关注到消极到关注到关注的转变。积极刺激注意力、学习和记忆。与 RDoC 一致，我们将在一个分析中利用多个分析单元（电路、性能、自我报告）跨诊断样本丰富了一系列与 ER 相关的网络功能、隐性注意力偏差和 ER 我们将招募 200 名患有情绪稳定情绪障碍的成年人（41-80 岁）（100 BD，100 MDD），和 100 个人口统计匹配的健康对照，使我们能够捕捉到从极端积极到极端积极的范围我们将评估基于表现的情感偏见、认知控制、和静息态功能连接（FC），以定义 ER 电路中与年龄相关的变化。习惯性使用 ER 策略、社会功能和幸福感来确定基于大脑的过程如何影响这些与功能和临床相关的结果。该项目的目标与 NIMH 战略计划直接一致，旨在开发新的方法。表征和治疗以理解大脑机制为基础的精神疾病。超越理解中期 ER 的具体机制和发展轨迹的启发价值和晚年，结果可用于指导新干预措施的开发（例如神经刺激、认知干预）旨在“拯救”导致 ER 适应不良的特定网络功能障碍在抑郁症中。