Predicting Sleep, Smoking and Lung Health Disparities in at-risk Black African American Adults

预测高危黑人非裔美国成年人的睡眠、吸烟和肺部健康差异

基本信息

批准号：
10307075
负责人：
Freda Patterson
金额：
$ 61.27万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10307075
关键词：
Acculturation Address Adult African American African American population Age Alcohols Anxiety Attitude Belief Black Populations Black race Body mass index Chronic Obstructive Pulmonary Disease Cigarette Classification Crowding Data Diagnosis Diet Disease Progression Enrollment Environmental Risk Factor Epidemiology Equation Esthetics Etiology Future Goals Growth Habits Health Heterogeneity Hour Household IL8 gene Impairment Incidence Individual Inflammation Interleukin-1 Interleukin-6 Intervention Knowledge Lead Lighting Measures Mental Depression Minority Health Research Mission Modeling National Institute on Minority Health and Health Disparities Nicotine Dependence Not Hispanic or Latino Observational Study Onset of illness Outcome Phenotype Predictive Factor Primary Prevention Pulmonary Function Test/Forced Expiratory Volume 1 Quality of life Race Reporting Research Support Risk Risk Factors Sampling Secondary Prevention Sleep Sleep Deprivation Smoker Smoking Smoking Behavior Smoking and Health Research Social support Subgroup Symptoms TNF gene Testing Time Tobacco use Work aged base cigarette smoking classification trees contextual factors demographics density design disparity reduction experience health care availability health care quality health disparity health disparity populations high risk high risk population inflammatory marker lung health middle age minority health disparity modifiable risk mortality multidisciplinary neighborhood safety perceived discrimination poor sleep prospective pulmonary function racial disparity regression trees sedentary sleep health sleep quality social social cohesion social factors systemic inflammatory response

项目摘要

Project Abstract Black/African American's (BAAs) are more likely to report insufficient sleep duration (<7 hours) and other sleep deficiencies (e.g., poor sleep quality), and to have advanced Chronic Obstructive Pulmonary Disease (COPD), than Non-Hispanic Whites (NHW) with similar smoking behaviors. Insufficient sleep has been related to: (1) continued cigarette smoking, and (2) impaired lung function in healthy adults. Thus, sleep deficiencies could be an “upstream” primary and/or secondary prevention target to address racial disparities in tobacco use and COPD onset and progression. Not known are the multi-level (i.e., individual, social and environmental) factors that predict insufficient sleep duration and other sleep deficiencies in BAA's across time, and the extent to which sleep deficiencies predict poorer health outcomes such as continued tobacco use and worsening lung function in BAA smokers. To address these knowledge gaps, we will conduct a multi-disciplinary 5-year prospective observational study that will enroll and follow a representative sample of 480 BAAs who are current smokers, are aged >39 years, and who have prodromal (GOLD stage 0) or early stage COPD (GOLD stage 1-2). We will prospectively examine key individual, social, and environmental variables in concert with objectively measured sleep metrics, tobacco use, inflammatory markers, and lung function in this health disparate sample. Longitudinal mixed, classification and regression, and structural equation modeling will define key predictors (and future intervention targets) of sleep deficiencies in BAA's as well as delineate the extent to which insufficient sleep (and other sleep deficiencies) interact with tobacco use and inflammation markers to predict worsening lung function. The expected outcome from this work is to define multi-level phenotypes of risk for sleep deficiencies, continued tobacco use, and worsening lung function in this health disparate population of mid-life BAA smokers. This work directly aligns with, and advances the NIMHD mission to conduct and support research in minority health and health disparities.

项目摘要黑人/非裔美国人 (BAA) 更有可能报告睡眠时间不足（<7 小时）和其他睡眠不足（例如睡眠质量差），并且患有晚期慢性病阻塞性肺疾病 (COPD) 与吸烟情况相似的非西班牙裔白人 (NHW) 相比睡眠不足的行为与：(1) 持续吸烟，以及 (2) 因此，健康成年人的肺功能受损，睡眠不足可能是一个“上游”。初级和/或二级预防目标，以解决烟草使用方面的种族差异和 COPD 的发病和进展是多层面的（即个人、社会和）。预测睡眠时间不足和其他睡眠不足的环境）因素 BAA 随时间的变化，以及睡眠不足在多大程度上预示着较差的健康结果例如，BAA 吸烟者持续使用烟草和肺功能恶化，以解决这些问题。知识差距，我们将进行一项为期 5 年的多学科前瞻性观察研究将登记并跟踪 480 名当前吸烟者、年龄较大的 BAA 的代表性样本 >39 岁，并且患有前驱期（GOLD 0 期）或早期 COPD（GOLD 1-2 期）。我们将前瞻性地研究关键的个人、社会和环境变量客观测量睡眠指标、烟草使用、炎症标志物和肺功能这种健康不同的样本进行纵向混合、分类和回归以及结构。方程模型将定义睡眠的关键预测因素（和未来的干预目标） BAA 的缺陷以及描述睡眠不足（和其他睡眠）的程度缺陷）与烟草使用和炎症标志物相互作用来预测肺部恶化这项工作的预期结果是定义风险的多层次表型。睡眠不足、持续吸烟和肺功能恶化在这种健康差异中这项工作直接符合并推动了 NIMHD 的发展。使命是开展和支持少数族裔健康和健康差异方面的研究。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Meeting the 24-hr movement guidelines: An update on US youth with autism spectrum disorder from the 2016 National Survey of Children's Health.

遵守 24 小时运动指南：2016 年全国儿童健康调查中关于患有自闭症谱系障碍的美国青少年的最新信息。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Healy, Seán;Aigner, Carrie J;Haegele, Justin A;Patterson, Freda
通讯作者：
Patterson, Freda

Does meeting physical activity recommendations ameliorate association between television viewing with cardiovascular disease risk? A cross-sectional, population-based analysis.

满足身体活动建议是否会改善看电视与心血管疾病风险之间的关联？

DOI：
发表时间：
2020
期刊：
影响因子：
2.9
作者：
Patterson, Freda;Mitchell, Jonathan A;Dominick, Gregory;Lozano, Alicia J;Huang, Liming;Hanlon, Alexandra L
通讯作者：
Hanlon, Alexandra L

HIV status and sleep disturbance in college students and relationship with smoking.

大学生的艾滋病毒状况和睡眠障碍及其与吸烟的关系。