TOTAL SYNTHESIS OF COMPLEX MOLECULES

复杂分子的全合成

• 批准号: 2176473
• 负责人: K. C. NICOLAOU
• 金额: $ 18.74万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2176473
• 关键词: chemical structure function; chemical synthesis; cyclization; epoxides; ketones; lactones; neurotoxins; sodium channel; stereochemistry; stimulant /agonist; thioester; thioether

This program is directed towards the completion of the total synthesis of brevetoxin A and ciguatoxin. Both compounds are potent neurotoxins isolated from marine organisms. Their total syntheses are expected to be accompanied by discoveries in the area of mew synthetic technologies and strategies and may have implications in the neurosciences, the understanding and protection of the marine environment, and medicine. The key steps in the syntheses involve the application of novel methods for the construction of 6-, 7-, 8- and 9-membered cyclic ethers using thionoesters, thionolactones, hydroxyepoxides, hydroxyketones and hydroxydithioketals as precursors.

该程序针对完成的总合成 Brevetoxin A和Ciguatoxin。 两种化合物都是有效的神经毒素 从海洋生物中分离出来。 他们的总合成将是 伴随着MEW合成技术领域的发现 策略，可能对神经科学有影响， 了解和保护海洋环境和医学。 这 合成中的关键步骤涉及应用新方法的应用 使用thionoesters构建6，7-，8和9元的循环以醚， 硫二酮，羟基氧化物，羟基酮酮和羟基二硫代酮作为 前体。