MECHANICS AND ENERGETICS IN MITRAL REGURGITATION

二尖瓣反流的力学和能量学

• 批准号: 2214467
• 负责人: CLEVELAND W LEWIS
• 金额: $ 2.86万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-01-09 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2214467
• 关键词: MECHANICS; ENERGETICS; MITRAL; REGURGITATION; MECHANICS; ENERGETICS; MITRAL; REGURGITATION

Chronically instrumented conscious dogs will be studied during the development of congestive heart failure due to mitral regurgitation. New load insensitive measures of systolic performance and cardiac energetics will be used to quantify a large animal, closed-chested model of mitral regurgitation. This chronic model will be used to identify the determinants of myocardial dysfunction and altered energy utilization observed in this disease. These studies should provide insight into the pathophysiology of chronic mitral regurgitation, allowing the development of new therapeutic modalities.

长期有仪器有意识的狗将在 由于二尖瓣反流引起的充血性心力衰竭的发展。 新的 负载不敏感的收缩期性能和心脏能量 将用于量化二尖瓣的大动物，闭合胸 反流。 该慢性模型将用于识别 心肌功能障碍和能量利用率改变的决定因素 在这种疾病中观察到。 这些研究应洞悉 慢性二尖瓣反流的病理生理学，允许发育 新的治疗方式。