Toward novel translucent and strong nanostructured dental zirconia

开发新型半透明且坚固的纳米结构牙科氧化锆

基本信息

批准号：
10273470
负责人：
Yu Zhang
金额：
$ 25.61万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-10-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10273470
关键词：
Address Behavior Biological Models Ceramics Chemical Warfare Clinical Conflict (Psychology)Data Dental Dental Porcelain Dental Technicians Dentistry Dependence Development Elements Engineering Esthetics Evaluation Exhibits Failure Fatigue Fracture Goals Grain Healthcare High temperature of physical object Industry Knowledge Laboratories Laws Light Macor Mechanics Metals Methodology Methods Military Personnel Modernization Morbidity - disease rate Motion Nanostructures Nature Oral cavity Property Prosthesis Public Health Quality of life Research Resistance Stress Fractures Structure Technology Testing Time Tooth structure Ultrafine base clinically relevant cost improved innovation knowledge base mechanical properties minimally invasive nano nanopowder nanoscale next generation novel premature preservation restorative ceramics restorative dentistry restorative material simulation success yttria zirconium oxide

项目摘要

Project Summary/Abstract The attainment of both translucency and strength is a vital requirement for ceramic restorative materials. Unfortunately, these properties are often mutually exclusive. Porcelain-based and glass-ceramic materials have higher translucency but lower strength, and are thus susceptible to premature failure. Zirconia-based ceramics are stronger and tougher but have poor translucency. There is therefore an urgent need to develop translucent and strong ceramics for the next generation of better-performing restorative materials. Accordingly, the long-term goal of this project is to develop esthetic, strong, and abrasion-resistant nanocrystalline yttria- stabilized tetragonal zirconia polycrystals (Y-TZP) for dental and biomedical applications. The overall objectives in this application are: (1) optimize the translucency and strength of nanocrystalline Y-TZP via compositional and microstructural tailoring; and (2) elucidate microstructure-mechanical properties of Y-TZP at the nano and microscale levels. To our knowledge, this proposal is the first to systematically address these questions. The central hypothesis is that nanocrystalline Y-TZP exhibits improved translucency, strength and reduced abrasiveness relative to its microcrystalline counterparts. This hypothesis is formulated on the basis of preliminary results produced in the applicants’ laboratories. To test this hypothesis, we will pursue 3 specific aims: (1) Optimize nanostructured Y-TZP for translucency and strength; (2) Elucidate the dependence of translucency, strength degradation and toughness on Y-TZP microstructure; and (3) Determine resistance to fatigue and wear of nanostructured Y-TZP using a mouth-motion simulator. The approach is innovative because it departs from the status quo by developing a new form of nanocrystalline Y-TZP with improved translucency and fracture resistance and reduced abrasiveness using novel processing methodologies. The proposed research is significant because it extends clinical indications for zirconia to the esthetic zone and promises minimally invasive treatments. Such an approach will prolong prosthetic lifetimes and preserve tooth structure, thus reducing money and time spent correcting premature failures. As an adjunct benefit, the development of nanocrystalline Y-TZP will provide a model system for establishing a broader correlation between mechanical properties and grain size, thus extending classical fracture mechanics laws into the nanoscale domain.

项目概要/摘要实现半透明性和强度是陶瓷修复材料的重要要求。不幸的是，瓷基材料和玻璃陶瓷材料的这些特性通常是相互排斥的。半透明度较高，但强度较低，因此容易过早失效。陶瓷强度更高、韧性更强，但透光性较差，因此迫切需要开发。半透明且坚固的陶瓷可用于下一代性能更好的修复材料。该项目的长期目标是开发美观、坚固且耐磨的纳米晶氧化钇- 用于牙科和生物医学应用的稳定四方氧化锆多晶 (Y-TZP)。该应用的目标是：(1) 通过优化纳米晶 Y-TZP 的半透明度和强度成分和微观结构定制；(2) 阐明 Y-TZP 的微观结构-机械性能据我们所知，该提案是第一个系统地解决这些问题的提案。中心假设是纳米晶体 Y-TZP 表现出改善的半透明度、强度和性能。相对于其微晶附件，磨损性降低。该假设是在其基础上提出的。申请人实验室得出的初步结果为了检验这一假设，我们将追求 3 个具体的结果。目标：（1）优化纳米结构 Y-TZP 的半透明度和强度；（2）阐明 Y-TZP 微观结构的半透明度、强度退化和韧性；以及 (3) 确定耐腐蚀性；使用嘴部运动模拟器研究纳米结构 Y-TZP 的疲劳和磨损该方法是创新的。因为它脱离了现状，开发了一种新型纳米晶Y-TZP，具有改进的性能使用新颖的加工方法实现半透明性和抗断裂性并降低磨损性。拟议的研究意义重大，因为它将氧化锆的临床适应症扩展到了美容区域，并且这种方法有望延长假牙的使用寿命并保护牙齿。结构，从而减少纠正过早故障所花费的金钱和时间。纳米晶 Y-TZP 的开发将为建立更广泛的相关性提供模型系统机械性能和晶粒尺寸之间的关系，从而将经典断裂力学定律扩展到纳米级域。