Interconnections among Cognition, Pain, and Physical Function in Aging.

衰老过程中认知、疼痛和身体功能之间的相互联系。

• 批准号: 10224654
• 负责人: Thomas W Buford
• 金额: $ 10.49万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10224654
• 关键词: Address; Advisory Committees; Affective; Age; Aging; Alabama; Alzheimer' s Disease; Area; Award; Biometry; Brain; Chronic; Chronic low back pain; Cognition; Cognition Disorders; Cognitive; Cohort Studies; Collaborations; Complex; Coupled; Creativeness; Data; Data Collection; Data Sources; Degenerative polyarthritis; Dementia; Development; Doctor of Philosophy; Educational Curriculum; Educational workshop; Elderly; Epidemic; Exercise; Funding; Future; Gait speed; Goals; Health; Hypertension; Independent Scientist Award; Interdisciplinary Study; International; Knowledge; Knowledge acquisition; Laboratories; Lead; Leadership; Learning; Literature; Maintenance; Medicine; Mentors; Methods; Morbidity - disease rate; National Institute on Aging; Neck; Outcome; Oxygen; Pain; Pain Threshold; Pain management; Persons; Pharmacological Treatment; Physical Exercise; Physical Function; Pilot Projects; Population; Positron-Emission Tomography; Prospective Studies; Psychology; Psychosocial Factor; Publications; Quality of life; Race; Randomized Controlled Trials; Reading; Recording of previous events; Research; Research Personnel; Science; Scientist; Sensory; Site; Testing; Therapeutic; Time; Training; Training Programs; Universities; Virginia; age related cognitive disorder; biopsychosocial; career; chronic pain relief; cognitive function; cognitive neuroscience; design; disability; experience; health management; healthy aging; improved; indexing; innovation; interdisciplinary approach; knee pain; laboratory experience; meetings; mid-career faculty; mild cognitive impairment; mortality; novel; opioid abuse; pain reduction; preservation; prevent; programs; prospective; research study; skill acquisition; skills; success; symposium; therapy design

Project Summary This application is for an Independent Scientist Award (K02) from the National Institute on Aging. The candidate, Dr. Thomas W. Buford, is an Associate Professor in the Department of Medicine at the University of Alabama at Birmingham. Dr. Buford has to date established a strong scientific track record in aging and the preservation of physical function. His long-term goal is to establish a sustainable research program focused on identifying and developing therapeutic strategies for the preserving physical independence among older adults. The objective of this application is to provide the candidate with the protected time necessary to acquire knowledge and skills needed to incorporate two inter-related areas, cognitive health and pain management, into his existing research program. These areas represent two major epidemics in aging including chronic opioid abuse and cognitive disorders including mild cognitive impairment, Alzheimer’s, and other dementias. While these areas are recognized as high-priorities for older adults and are associated with declining physical function, few investigators to date have routinely incorporated these factors into prospective studies concerning the preservation of physical function among older adults. Acquiring expertise in these areas will provide the candidate with a more nuanced view of the key issues surrounding the preservation of physical independence. Award activities will also lead to and expanded skillset, ultimately contributing to an improved ability to design and execute research studies capable of making meaningful impacts on the health and quality of life of older adults. The training plan includes three primary objectives which are to: 1) Acquire new knowledge and skills to the assessment and maintenance of cognition in aging, 2) acquire new knowledge and skills in the assessment and treatment of pain in older adults, and 3) advance mentoring and leadership skills necessary to support a sustainable research program. The research plan is designed to integrate with the training plan to provide the candidate with opportunities to 1) utilize established data sources to explore novel relationships between cognition/pain and indices of physical function, and 2) participate in prospective data collection to learn laboratory methods in these areas and generate novel data in these areas. His advisory team includes established, well-funded experts in both cognition (Ronald Lazar, PhD; Virginia Wadley, PhD) and pain (Roger Fillingim, PhD, Burel Goodin, PhD) in aging as well in biostatistics (Gerald McGwin, PhD) and research leadership (Marcas Bamman, PhD). This outstanding team will facilitate the candidate’s success in integrating these new concepts with his existing research. This K02 award will provide the candidate with protected time to expand his research program which will enhance the overall creativity and sustainability of his research. Ultimately this progress is expected to enhance his potential to make significant contributions to the field of healthy aging and to improve the training of future mentees by creating a more interdisciplinary approach incorporating principles from physical, cognitive, and pain sciences.

项目概要 本申请旨在申请国家老龄化研究所颁发的独立科学家奖（K02）。 候选人托马斯·W·布福德 (Thomas W. Buford) 博士是纽约大学医学系副教授 伯明翰阿拉巴马州的布福德博士迄今为止在衰老和衰老方面建立了良好的科学记录。 他的长期目标是建立一个专注于身体机能的可持续研究计划。 制定和治疗策略以保持老年人的身体独立。 此应用程序的目的是为候选人提供获得所需的受保护时间 整合认知健康和疼痛管理这两个相互关联的领域所需的知识和技能， 这些领域代表了衰老的两个主要流行病，包括慢性病。 阿片类药物滥用和认知障碍，包括轻度认知障碍、阿尔茨海默病和其他痴呆症。 虽然这些领域被认为是老年人优先考虑的领域，并且与身体素质下降有关 功能，迄今为止很少有研究人员定期将这些因素纳入有关的前瞻性研究中 获得这些领域的专业知识将有助于保持老年人的身体机能。 候选人对围绕保护身体独立的关键问题有更细致的看法。 奖励活动还将扩大技能范围，最终有助于提高设计能力 并开展能够对老年人的健康和生活质量产生有意义影响的研究 培训计划包括三个主要目标： 1) 获得新的知识和技能 衰老过程中认知的评估和维持，2）在评估中获得新的知识和技能 和治疗老年人的疼痛，以及 3) 提高必要的指导和领导技能，以支持 研究计划旨在与培训计划相结合，以提供可持续的研究计划。 候选人有机会 1）利用已建立的数据源来探索之间的新关系 认知/疼痛和身体机能指数，2）参与前瞻性数据收集以学习 他的顾问团队包括这些领域的实验室方法并生成这些领域的新颖数据。 认知（Ronald Lazar 博士；Virginia Wadley 博士）和疼痛（罗杰 Fillingim 博士、Burel Goodin 博士）在衰老以及生物统计学（Gerald McGwin 博士）和研究方面 领导力（马卡斯·巴曼博士）。这个优秀的团队将促进候选人成功融入。 这些新概念与他现有的研究相结合，该 K02 奖项将为候选人提供受保护的时间。 扩大他的研究计划，这将提高他研究的整体创造力和可持续性。 最终，这一进展预计将增强他在该领域做出重大贡献的潜力 健康老龄化并通过创建更具跨学科的方法来改善未来受训者的培训 结合物理、认知和疼痛科学的原理。