CLINICAL ASSESSMENT OF THE NERVE FIBER LAYER IN GLAUCOMA

青光眼神经纤维层的临床评估

• 批准号: 2165235
• 负责人: LINDA M ZANGWILL
• 金额: $ 19.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2165235
• 关键词: African American; age difference; caucasian American; diagnosis design /evaluation; eye disorder diagnosis; eye fundus photography; glaucoma; glaucoma test; human subject; longitudinal human study; ophthalmoscopy; optic nerve disorder; polarimetry

This application describes a five year longitudinal study of structural change in primary open angle glaucoma. This study will evaluate whether clinical evaluation with confocal scanning laser imaging an improve the detection of glaucomatous optic nerve damage and change. Specific Aims: 1. To evaluate and compare photographic and confocal scanning laser imaging techniques to detect optic and retinal nerve fiber layer damage and change. 2. To determine the quantitative temporal relationships between recognizable optic nerve damage and measurable visual field loss and how these relationships differ among patients. 3. To quantify age-related changes in the optic nerve in normal healthy eyes. Methods: This study will include 300 subjects aged 40 and older; 100 patients with primary open angle glaucoma, and 100 White and 100 African- American normal controls. Each subject will have a complete ophthalmologic and visual field examination annually. Images of the optic nerve will be obtained using photographic techniques (optic disc and retinal nerve fiber layer photography), confocal laser scanning ophthalmoscopy to determine optic disc and perpipapillary topography, and confocal scanning laser polarimetry to determine nerve fiber layer thickness. These data will be evaluated qualitatively and quantitatively for evidence o glaucomatous damage and change. This study will evaluate whether these advances in fundus imaging technology can improve the precision with which we can differentiate between normal and glaucoma eyes, and can detect and monitor glaucomatous optic neuropathy.

该应用描述了一项五年的结构研究 一级开头青光眼的变化。 这项研究将评估是否 共聚焦扫描激光成像的临床评估改进 检测青光眼视神经损伤和变化。 具体目的：1。评估和比较摄影和共焦 扫描激光成像技术以检测视神经和视网膜神经纤维 层损坏和变化。 2。确定定量时间 可识别的视神经损伤与可测量的视觉 现场损失以及这些患者之间的关系如何不同。 3 在正常健康的眼睛中量化视神经与年龄相关的变化。 方法：这项研究将包括300名40岁及以上的受试者； 100 初级开头青光眼的患者，100名白色和100名非洲 - 美国正常对照。 每个主题将具有完整的眼科 和每年视觉现场检查。 视神经的图像将是 使用照相技术（视盘和视网膜神经纤维 图层摄影），共聚焦激光扫描眼镜检查以确定 视盘和垂直毛皮地形以及共聚焦扫描激光器 极化法以确定神经纤维层的厚度。 这些数据将是 在定性和定量上评估证据 损坏和改变。 这项研究将评估这些进展是否在眼底成像方面 技术可以提高我们可以区分的精度 在正常和青光眼之间，可以检测和监测青光眼 视神经病变。