Quantitative PET/MRI of brain oxygenation in cerebrovascular disease

脑血管疾病脑氧合定量 PET/MRI

基本信息

批准号：
10218276
负责人：
Audrey Peiwen Fan
金额：
$ 22.79万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-15 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218276
关键词：
Acetazolamide Address Affect Biological Biological Markers Blood Blood Vessels Blood capillaries Brain Brain imaging Carotid Stenosis Cause of Death Cerebrovascular Disorders Cerebrum Clinical Collaborations Communities Complex Consensus Consumption Development Diagnosis Dictionary Disease Equipment Fingerprint Functional disorder Gases Hospitals Human Hybrids Image Imaging Device Imaging Techniques Impairment Inhalation Injections Institution Intervention Lead Magnetic Resonance Imaging Magnetism Maps Measurement Measures Medical Metabolic Metabolism Methods Modeling Moyamoya Disease Multicenter Trials Nerve Degeneration Neurologist Neurosurgeon Outcome Oxygen Patients Perfusion Physiologic pulse Physiological Physiology Population Positron-Emission Tomography Predisposition Procedures Protocols documentation Reference Standards Relaxation Reproducibility Research Personnel Resolution Rest Sagittal Sinus Sampling Scanning Signal Transduction Stenosis Stroke Stroke prevention Surgeon Symptoms Techniques Tissue Extracts Tissue Viability Tissue imaging Tissues Tracer Traumatic Brain Injury United States Validation Vasodilator Agents Venous Water Work acute stroke base biophysical model blood oxygen level dependent brain tissue cerebral oxygenation cerebrovascular clinical research site cohort deoxyhemoglobin design disability healthy volunteer high risk imaging approach imaging modality imaging study imaging system improved in vivo innovation insight nervous system disorder non-invasive imaging novel novel imaging technique patient stratification radiotracer spatiotemporal stroke outcome stroke recovery stroke risk tissue oxygenation tool tumor

项目摘要

Stroke is a leading cause of death and disability and creates a societal burden of $34 billion each year in the United States alone. While new endovascular treatments have shown promise to improve stroke outcomes and recovery, they have been hampered by the lack of noninvasive biomarkers to identify patients who are good candidates for these therapies. In particular, imaging of brain oxygenation is a long-recognized but unmet need in the stroke community, and we propose to use magnetic resonance imaging (MRI) to address this need. This project develops a clinically feasible toolset to noninvasively image brain tissue oxygenation by magnetic resonance imaging. Our specific aims are (1) to develop new MRI techniques, quantitative BOLD and vascular fingerprinting, that utilize a novel pulse sequence to quantify oxygen extraction fraction (OEF) levels in cerebral tissues; (2) to validate MR OEF imaging with simultaneous [15O] positron emission tomography (PET) reference images in patients with cerebrovascular disease; and (3) to apply MRI OEF methods to study oxygenation status in patients with carotid artery stenosis who are at high risk of stroke. The innovation of this work lies in the development of a novel imaging technique to assess quantitative OEF in brain tissues. The use of a hybrid PET/MRI system to validate the new OEF imaging methods with simultaneous measurements by [15O] PET is also highly novel. The outcome of proposal is a validated MRI tool to image OEF, and quantitative MRI observations of OEF in patients with carotid artery stenosis, and its relationship to patient symptoms and perfusion status. The significance of this work is a clinically feasible MRI protocol to image tissue OEF that is transferrable to any clinical site. The reproducible and robust tool will allow the stroke imaging community to better stratify patients for new treatments, and implement multi-center trials to evaluate endovascular interventions to reduce stroke risk in these populations.

中风是导致死亡和残疾的主要原因，仅在美国每年就造成 340 亿美元的社会负担。虽然新的血管内治疗已显示出改善中风结果和恢复的希望，但由于缺乏非侵入性生物标志物来识别适合这些治疗的患者，这些治疗受到了阻碍。特别是，脑氧合成像是中风界长期以来公认但尚未满足的需求，我们建议使用磁共振成像（MRI）来满足这一需求。该项目开发了一种临床上可行的工具集，通过磁共振成像对脑组织氧合进行无创成像。我们的具体目标是 (1) 开发新的 MRI 技术、定量 BOLD 和血管指纹识别技术，利用新型脉冲序列来量化脑组织中的氧提取分数 (OEF) 水平； (2) 在脑血管疾病患者中验证 MR OEF 成像与同步 [15O] 正电子发射断层扫描 (PET) 参考图像； (3)应用MRI OEF方法研究脑卒中高危颈动脉狭窄患者的氧合状态。这项工作的创新之处在于开发了一种新颖的成像技术来评估脑组织中的定量 OEF。使用混合 PET/MRI 系统通过 [15O] PET 同步测量来验证新的 OEF 成像方法也是非常新颖的。该提案的成果是一种经过验证的 MRI 工具，用于对 OEF 进行成像，并对颈动脉狭窄患者的 OEF 进行定量 MRI 观察，及其与患者症状和灌注状态的关系。这项工作的意义在于提供了一种临床上可行的 MRI 方案，用于对组织 OEF 进行成像，并且可以转移到任何临床部位。这种可重复且强大的工具将使中风成像界能够更好地对患者进行新治疗分层，并实施多中心试验来评估血管内干预措施，以降低这些人群的中风风险。