RETINAL MICROCIRCUITRY--STRUCTURE AND FUNCTION

视网膜微电路——结构和功能

• 批准号: 2161665
• 负责人: KEN-ICHI NAKA
• 金额: $ 26.65万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2161665
• 关键词: DVD /CD ROM; action potentials; alternatives to animals in research; amacrine cells; catfish; electrodes; electrophysiology; fish; horizontal cell; mathematical model; neural conduction; neural information processing; neural transmission; neuroanatomy; photostimulus; retinal bipolar neuron; retinal ganglion; stimulus /response; synapses; visual stimulus

The long-term goal of this 25-year-old research is to discover the principles involved in signal processing in the neuron network in the: vertebrate retina and to produce a mathematical model of the neuron: network based on these principles. There is a set of principles that is particular to the operation of the neuron network and is different from the set of principles that governs ionic or channel mechanisms. At the turn of this century, S. Ramon y Cajal established the neuron doctrine which states that each single neuron functions more or less independently. Golgi, on the other hand, maintained that neurons form a syncytium, the neuroreticulum. Lately, structural as well as morphological evidence is accumulating to suggest that many neurons in the retina form a syncytium which is referred to as a neuron space (in which neurons are tightly coupled) or a neuron cluster (in which neurons are loosely coupled). For example, the horizontal and transient amacrine cells form two independent spaces and sustained amacrine cells form two independent clusters. Our two main goals are: l) Identification of signal transmission between neurons in the inner retina. We will study the way in which signals are transmitted between neurons in a space or in a cluster and the way in which spaces and. clusters interact with each other. In this series of experiments, the space and cluster will also be identified morphologically by intracellular injection of neuro-tracers. 2) The receptive field will be explored by the use of many types of light stimulus in an effort to define a field in time and space (spatiotemporal receptive field) and to try to decompose a response into two components, one that is intrinsic to the cell and the other that reflects the activity of the network.

这项25年历史的研究的长期目标是发现 神经元网络中信号处理涉及的原则： 脊椎动物视网膜并产生神经元的数学模型： 基于这些原则的网络。有一组原则是 特定于神经元网络的操作，与 控制离子或渠道机制的一组原理。 在本世纪初，S。RamonY Cajal建立了神经元 学说指出，每个神经元或多或少发挥作用 独立。另一方面，高尔基坚持认为神经元形成a 合胞菌，神经尿素。 最近，结构和 形态学证据正在积累，以表明许多神经元中的许多神经元 视网膜形成合成剂，称为神经元空间（其中 神经元紧密耦合）或神经元簇（神经元为 松散耦合）。例如，水平和瞬态无长突细胞 形成两个独立的空间，持续的无长束细胞形成两个 独立集群。我们的两个主要目标是： l）鉴定内部神经元之间的信号传递 视网膜。我们将研究信号之间传输的方式 空间或集群中的神经元以及空间和空间的方式。 群集相互作用。在这一系列实验中， 空间和簇还将通过细胞内鉴定 注射神经追踪器。 2）将通过使用许多类型的光来探索接收场 刺激以定义时间和空间的字段（时空时空） 接受场），并试图将响应分解为两个组成部分， 一个与细胞固有的，另一个反映活性的 网络。