Neural and motivational mechanisms of age-related change in emotion regulation

年龄相关情绪调节变化的神经和动机机制

• 批准号: 10209489
• 负责人: Tammy English
• 金额: $ 57.37万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10209489
• 关键词: Address; Adult; Affective; Age; Aging; Behavior assessment; Behavioral; Brain; Cicatrix; Code; Cognitive; Corpus striatum structure; Cues; Data; Data Set; Decision Making; Depressed mood; Development; Diagnostic; Dimensions; Disease remission; Ecological momentary assessment; Elderly; Emotional; Emotions; Exhibits; Facial Expression; Foundations; Functional Magnetic Resonance Imaging; Goals; Image; Incentives; Individual; Individual Differences; Influentials; Intervention; Interview; Knowledge; Laboratories; Lateral; Life; Maintenance; Major Depressive Disorder; Matched Group; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Modeling; Motivation; Neurobiology; Nucleus Accumbens; Participant; Patient Self-Report; Pattern; Play; Population; Prefrontal Cortex; Process; Protocols documentation; Quality of life; Recording of previous events; Recurrence; Research; Rewards; Role; Sampling; Scanning; Source; Standardization; System; Testing; Update; Variant; Ventral Striatum; Woman; age effect; age related; base; cognitive control; cognitive function; cognitive reappraisal; design; emotion dysregulation; emotion regulation; emotional experience; emotional functioning; experience; healthy aging; improved; individual variation; innovation; insight; meetings; middle age; neural circuit; neuroeconomics; neuroimaging; neuromechanism; novel; positive emotional state; prevent; racial and ethnic; racial diversity; relating to nervous system; response; reward processing; side effect; success; therapeutic target; trait

PROJECT SUMMARY In the progression from middle to older-age, healthy adults typically experience improvements in their emotional functioning, such as increases in positive emotion and greater expertise in managing emotions. However, not everyone shows these age-related improvements, and the mechanisms that give rise to emotional functioning changes across adulthood are still poorly understood. The primary goal of this project is to examine the critical factors that promote positive emotional development in normative aging, and to test whether depression history might moderate this process as a key trait individual difference marker. To this end, we test our proposed Value- Based Cognitive Control Model of Emotion Regulation in ADulthood (VBCC-MERiAD). The VBCC-MERiAD framework suggests a novel insight: that interactions between reward motivation and cognitive control play a central role in understanding both the normative trajectory of emotional functioning in older adults, and conversely, why and how individuals with depression histories may get “off track”. We focus on effectively upregulating positive emotion, given that older adults prioritize positive emotion goals, and because depression is characterized by blunted reward processing. Our primary hypothesis is that positive emotion regulation (ER) abilities will rely upon the integrity of fronto-striatal circuitry (i.e., activity and connectivity between the lateral prefrontal cortex and nucleus accumbens / ventral striatum). Engagement of this circuit is predicted to reflect the utilization of reward motivation as a means of engaging cognitive control (i.e., to update and maintain ER goals). Across three Specific Aims, we propose to characterize the mechanisms of ER in middle-aged and older adults (35-74), focusing on neural and behavioral indicators of motivation and cognitive control that predict daily emotional functioning, and potential dysregulation in individuals with depression history. To achieve these aims, we will employ a multi-method design involving functional neuroimaging measures, laboratory behavioral assessments, and experience sampling methods. The sample (N=220) will include an ethnically/racially diverse set of adults (66% women) of ages 35-74, equally subdivided into two groups: healthy controls and people with depression histories. A state-of-the art neuroimaging protocol will assess brain activity associated with different ER strategies, and test for linkages with reward-motivated cognitive control. The comprehensive laboratory assessments will include diagnostic interviewing, self-report measures, cognitive functioning batteries, and a standardized ER task with measures of autonomic reactivity and behavioral coding of emotion. The experience sampling protocol will provide a naturalistic, ecologically valid assessment of participants’ emotional experiences, goals and regulatory strategies. The proposed research will dramatically extend our understanding of both normative and dysfunctional age-related change in emotional function, by identifying mechanisms that promote positive ER in late adulthood. In so doing, we will lay the foundation for new interventions to improve quality of life for healthy older adults and preventative therapeutic targets for individuals with depression history.

项目概要 在中年到老年的过程中，健康成年人的情绪通常会得到改善 功能，例如积极情绪的增加和管理情绪的专业知识的增强。 每个人都表现出这些与年龄相关的改善，以及引起情绪功能的机制 人们对成年期的变化仍然知之甚少，该项目的主要目标是检查关键的因素。 促进正常衰老过程中积极情绪发展的因素，并测试是否有抑郁史 可能会调节这一过程作为关键特征个体差异标记。为此，我们测试了我们提出的值-。 基于成年情绪调节的认知控制模型 (VBCC-MERiAD)。 框架提出了一个新颖的见解：奖励动机和认知控制之间的相互作用发挥着 在理解老年人情绪功能的规范轨迹方面发挥着核心作用， 相反，我们重点关注有抑郁症病史的人为何以及如何“偏离正轨”。 上调积极情绪，因为老年人优先考虑积极情绪目标，并且因为抑郁 我们的主要假设是积极情绪调节（ER）。 能力将依赖于额纹状体电路的完整性（即，侧脑纹状体之间的活动和连接） 前额皮质和伏隔核/腹侧纹状体）预计会反映该回路的参与。 利用奖励动机作为参与认知控制的手段（即更新和维持 ER 目标）。 通过三个具体目标，我们建议描述中老年人 ER 的机制 (35-74)，重点关注每天预测的动机和认知控制的神经和行为指标 为了实现这些目标，有抑郁症史的个体的情绪功能和潜在的失调。 我们将采用多种方法设计，涉及功能性神经影像学测量、实验室行为学测量 评估和经验抽样方法样本 (N=220) 将包括种族/种族多样化。 年龄在 35-74 岁的成年人（66% 为女性），平均分为两组：健康对照者和患有此病的人 最先进的神经影像学方案将评估与不同抑郁症相关的大脑活动。 ER 策略，并测试与奖励驱动的认知控制的联系。 评估将包括诊断访谈、自我报告措施、认知功能电池和 标准化 ER 任务，测量自主反应和情绪行为编码。 抽样协议将为参与者的情绪提供自然的、生态上有效的评估 所提出的研究将极大地扩展我们的理解。 通过识别与年龄相关的情绪功能变化的机制， 促进成年晚期积极的 ER 这样做，我们将为改善新的干预措施奠定基础。 健康老年人的生活质量和有抑郁症史的个体的预防性治疗目标。