Administrative Core

行政核心

• 批准号: 10207345
• 负责人: Arlene H. Sharpe
• 金额: $ 37.75万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207345
• 关键词: Administrative Personnel; Animals; Applications Grants; Award; Bioinformatics; CRISPR screen; CRISPR/Cas technology; Caliber; Cells; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communication; Communities; Conflict (Psychology); Conflict of Interest; Data; Data Analyses; Ensure; Funding; Genetic Screening; Goals; Grant; Group Meetings; Guidelines; Hospitals; Human; Human Resources; Human Subject Research; Immunity; Individual; Infrastructure; Institutes; Institution; Lead; Leadership; Manuscripts; Mediating; Methods; Monitor; Online Systems; Pilot Projects; Preparation; Principal Investigator; Procedures; Process; Progress Reports; PubMed; Public Policy; Reporting; Research Personnel; Research Project Grants; Research Support; Resolution; Resource Sharing; Schedule; Scientist; Secure; Services; Structure; System; Teleconferences; Time; Travel; United States National Institutes of Health; Validation; acute infection; adaptive immune response; base; career; conflict resolution; data management; data portal; data sharing; in vivo; innovation; innovative technologies; medical schools; meetings; member; mouse model; novel; operation; organizational structure; programs; screening; success; web portal

The major objectives of the Administrative Core are to institute an infrastructure that facilitates productive interactions among the U19 Program investigators of this grant application, “Defining regulators of immunity to acute infection using CRISPR screens” and implements our Pilot Project program. The Administrative Core will serve as a centralized, transparent organizational structure to provide administrative support that enables the Principal investigators and their personnel to focus on their experimental and scientific goals. Dr. Sharpe, Program Director of the overall U19 grant, will provide leadership and direction for operations of the Administrative Core, which will be based at Harvard Medical School. Dr. Haining, Co-Director of this U19 grant and Core A, will lead the Pilot Grant Program. The Administrative Core will be responsible for carrying out the following functions: a) Provide the infrastructure for overall management and co-ordination; b) Facilitate and promote interactions and communication between program investigators, scientific advisors and administrative personnel; c) Plan and coordinate annual External Scientific Advisory Group (ESAG) meetings; d) Organize and coordinate travel for ESAG members; e) Assist the Program Directors and Principal Investigators with oversight of scientific, fiscal, regulatory and compliance matters, and with preparation and review of yearly progress reports and financial reports; f) Implement a plan for data management/sharing among investigators; and g) Implement the Pilot Project Program. The Administrative Core will also resolve all conflicts that may arise. To achieve these goals, Core A has the following specific aims: Aim 1: To provide infrastructure for overall management and coordination. Core A will provide administrative support and coordination to promote communication and interactions among Project and Core investigators, including the scheduling of regular teleconferences/face-to-face meetings and annual meetings, preparing and submitting annual progress reports, providing fiscal oversight and ensuring institutional compliance with fiscal, regulatory and scientific issues, and conflict resolution. Aim 2: To maintain a web-based portal for data sharing via a secure Dropbox. Core A will host and manage a secure Dropbox portal for data sharing within the U19. This easy access to data will maximize transparency, encourage collaboration, and aid in monitoring project progress and how collaborators are utilizing core services. Aim 3: To implement the Pilot Project Program. Core A will develop an effective process to solicit review and award high caliber innovative Pilot Projects that use our in vivo CRISPR platform, and monitor their progress. We will encourage applications from early career investigators. Through these specific Aims, we will create an Administrative Core structured to implement processes/procedures to enable the success of this highly collaborative program.

行政核心的主要目标是建立一个基础设施，以促进 本次拨款申请的 U19 计划研究人员之间富有成效的互动，“定义 使用 CRISPR 筛选调节急性感染免疫力”并实施我们的试点项目 行政核心将作为一个集中、透明的组织结构， 提供行政支持，使主要研究人员及其人员能够专注于 他们的实验和科学目标是 U19 总体资助项目主任 Sharpe 博士。 为行政核心的运作提供领导和指导，该核心将设在 哈佛医学院 U19 资助项目联合主任兼核心 A 项目的海宁博士将领导试点资助项目 管理核心将负责执行以下职能： a) 提供 整体管理和协调的基础设施； b) 促进和促进互动； c) 计划 并协调年度外部科学顾问小组 (ESAG) 会议； 协调 ESAG 成员的旅行； e) 协助项目主管和首席研究员 监督科学、财政、监管和合规事务，并准备和审查 f) 实施数据管理/共享计划 调查员；和 g) 实施试点项目计划还将解决所有问题。 为了实现这些目标，核心 A 有以下具体目标： 目标 1： 提供整体管理和协调的基础设施 核心 A 将提供行政管理。 支持和协调，促进项目和核心之间的沟通和互动 调查员，包括安排定期电话会议/面对面会议和年度会议 会议，准备和提交年度进度报告，提供财政监督并确保 财政、监管和科学问题的制度合规性以及冲突解决。 维护一个基于网络的门户，通过安全的 Dropbox Core A 进行数据共享并进行托管和管理。 用于在 U19 内共享数据的安全 Dropbox 门户，这种对数据的轻松访问将最大化。 透明度，鼓励合作，并帮助监控项目进展以及合作者如何 目标 3：实施试点项目计划 核心 A 将开发一个 有效的流程来征求审查并授予使用我们的体内的高水平创新试点项目 CRISPR 平台，并监控他们的进展，我们将鼓励早期职业生涯的应用。 通过这些具体目标，我们将创建一个行政核心，旨在 实施流程/程序，使这一高度协作的计划取得成功。