CORRECTION OF NEONATAL MONOCULAR APHAKIA WITH IOLS

用人工晶状体矫正新生儿单眼无晶状体

• 批准号: 2162338
• 负责人: SCOTT R LAMBERT
• 金额: $ 24.2万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2162338
• 关键词: Macaca; cataract surgery; congenital vision disorder; eye prosthesis; eye refraction disorder; growth /development; histochemistry /cytochemistry; implant; newborn animals; nonhuman therapy evaluation; postoperative complications; vision tests; visual pathways; visual perception

Monocular congenital cataracts are usually associated with a poor visual outcome. Factors which continue to limit the visual rehabilitation of these eyes after cataract removal include the less than ideal optical correction of the induced aphakia and amblyopia. This research project is a controlled study using a non-human primate model to evaluate the efficacy and safety of treating infants that have monocular congenital cataracts with intraocular lenses (IOLs). Its major objectives are to assess the effect of this treatment modality on: (1) visual acuity and contrast sensitivity using operant testing; (2) ocular growth; (3) long-term ocular complications evaluated clinically and histopathologically; and (4) neuroanatomical changes in the geniculostriate system using cytochrome oxidase histochemistry and parvalbumin and GABA immunoreactivity. These effects are being assessed in groups of monkeys who are monocularly pseudophakic: 2 groups with monofocal IOLs, 2 groups with multifocal IOLs, and 1 group of monkeys treated with a new paradigm (i.e., a higher powered multifocal IOL with no additional optical correction of the pseudophakic eye or occlusion therapy of the fellow eye). One of the two monofocal IOL groups and one of the two multifocal IOL groups also receive occlusion therapy of the fellow eye. Correlations between clinical, behavioral and neuroanatomical outcomes will be assessed and compared across the treatment groups.

单眼先天性白内障通常与视觉较差有关 结果。 继续限制视觉康复的因素 白内障后的这些眼睛包括不理想的光学 校正诱导的阿法基亚和弱视。 该研究项目是使用非人类灵长类动物的对照研究 评估具有治疗婴儿的功效和安全性的模型 具有眼内镜头（IOL）的单眼先天性白内障。 它的专业 目的是评估这种治疗方式的影响：（1） 使用操作测试的视力和对比度灵敏度； （2）眼 生长; （3）在临床上评估的长期眼并发症 组织病理学； （4）神经解剖学变化 使用细胞色素氧化酶组织化学和 白蛋白和GABA免疫反应性。 这些效果正在评估 在单眼的猴子群中：有2组 单焦点IOL，2组具有多焦点IOL和1组猴子 用新的范式处理（即，具有较高动力的多灶IOL 没有伪ic鼠眼或遮挡的其他光学校正 同伴的治疗）。 两个单焦点IOL组之一和一个 在两个多焦点IOL组中，也接受了遮挡疗法 同伴。 临床，行为和行为和 在整个过程中，将评估和比较神经解剖结局 治疗组。