Brain atrophy, cognitive impairment and Alzheimer's in low CVD-risk population

低心血管疾病风险人群中的脑萎缩、认知障碍和阿尔茨海默病

• 批准号: 10203685
• 负责人: CALEB E FINCH
• 金额: $ 103.59万
• 依托单位: CHAPMAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203685
• 关键词: 2019-nCoV; Administrative Supplement; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Bolivia; Bolivian; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Cognitive; Data; Dementia; Diet; Disease; Elderly; Epidemic; Funding; Genotype; Goals; Impaired cognition; Impairment; Incidence; Indigenous; Individual; Infection; Inflammation; Light; Longevity; Low Prevalence; Morbidity - disease rate; Neurologic; Parents; Phase; Physical activity; Population; Prevalence; Research; Risk; Virus Diseases; cardiovascular disorder risk; cerebral atrophy; cognitive function; cognitive testing; dementia risk; infection burden; inflammatory marker; mortality; neuroimaging

Project Summary The parent RF1 (1 RF1 AG054442-01) provides new data on brain atrophy and Alzheimer’s disease and Related Dementias (ADRD) in two indigenous Bolivian populations, the Tsimane and the Moseten, with extremely low rates of cardiovascular disease (CVD) but high burdens of infection and inflammation. The aims of this project are: (1) Longitudinal assessment of cognitive impairment and dementia in a low cardiovascular disease (CVD) risk population, Tsimane forager-horticulturalists of lowland Bolivia; (2) Neuroimaging to identify brain atrophy correlates of cognitive impairment, AD and other dementias; (3) Characterization of the prevalence of brain atrophy, cognitive impairment, and dementias in the Tsimane; (4) Collect in- depth data on diet and physical activity; and (5) Examine the interaction of inflammation and APOE genotype on cognitive functioning for individual longitudinal change. ADRD prevalence was estimated during the first 2.5 years of NIA funding. Current results indicate a low prevalence (<5%) of dementia after age 70 with no cases of moderate to severe dementia. The two specific aims of this administrative supplement will determine: (1) whether cognitive impairment and dementia are risk factors for SARS-CoV-2 infection and/or morbidity and mortality, if infected; and (2) if Covid-19 results cognitive and neurological aging impairment. The first aim is necessary for interpreting existing data and achieving the original project goals. it is necessary to determine whether those who develop cognitive impairment dementia are at greater risk for COVID-19 mortality in order to control for a potential downward bias in the estimation of dementia incidence. The second aim presents a new unique opportunity to investigate the original project goal of studying impacts of infection on cognitive decline and ADRD. It will evaluate the impact of COVID-19 infection on cognitive function and ADRD incidence.

项目概要 母体 RF1 (1 RF1 AG054442-01) 提供了有关脑萎缩和阿尔茨海默病的新数据 玻利维亚两个土著群体 Tsimane 中的疾病和相关痴呆症 (ADRD) 和莫塞滕 (Moseten)，心血管疾病 (CVD) 发病率极低，但疾病负担却很高 该项目的目的是：（1）纵向评估。 心血管疾病 (CVD) 低风险人群的认知障碍和痴呆， 玻利维亚低地的 Tsimane 采集者园艺家；(2) 神经影像学以识别脑萎缩 (3) 表征 (4) 收集- 有关饮食和体力活动的深度数据；以及 (5) 检查炎症和体力活动之间的相互作用； APOE 基因型对个体 ADRD 患病率认知功能的影响。 是在 NIA 资助的前 2.5 年中估计的。 70 岁以后痴呆症患病率（<5%），没有中度至重度痴呆病例。 本行政补充文件的两个具体目标将决定：(1) 认知是否 损伤和痴呆是 SARS-CoV-2 感染和/或发病的危险因素， 如果感染，死亡率；(2) Covid-19 是否导致认知和神经老化损害。 第一个目标对于解释现有数据和实现最初的项目目标是必要的。 有必要确定那些患有认知障碍痴呆症的人是否处于 更大的 COVID-19 死亡率风险，以控制潜在的向下偏差 第二个目标为痴呆症发病率的估计提供了一个新的独特机会。 调查研究感染对认知能力下降的影响的最初项目目标 ADRD 将评估 COVID-19 感染对认知功能和 ADRD 的影响。 发生率。

项目成果

Methodological differences cannot explain associations between health, anthropometrics, and excess resting metabolic rate.

方法学差异无法解释健康、人体测量学和过量静息代谢率之间的关联。

• 发表时间: 2019
• 影响因子: 2.8
• 作者: Gurven, Michael;Trumble, Benjamin;Stieglitz, Jonathan;Cummings, Dan;Kaplan, Hillard;Blackwell, Aaron D;Yetish, Gandhi;Pontzer, Herman
• 通讯作者: Pontzer, Herman

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.

玻利维亚土著采集者园艺师痴呆症和轻度认知障碍的患病率。

• 发表时间: 2023-01
• 作者: Gatz, Margaret;Mack, Wendy J;Chui, Helena C;Law, E Meng;Barisano, Giuseppe;Sutherland, M Linda;Sutherland, James D;Eid Rodriguez, Daniel;Quispe Gutierrez, Raul;Copajira Adrian, Juan;Bani Cuata, Jesus;Borenstein, Amy R;Walters, Ellen E;Irimia
• 通讯作者: Irimia

Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.

两个非工业南美人群的脑容量、能量平衡和心血管健康。

• 发表时间: 2023-03-28
• 影响因子: 11.1
• 作者: Kaplan, Hillard;Hooper, Paul L;Gatz, Margaret;Mack, Wendy J;Law, E Meng;Chui, Helena C;Sutherland, M Linda;Sutherland, James D;Rowan, Christopher J;Wann, L Samuel;Allam, Adel H;Thompson, Randall C;Michalik, David E;Lombardi, Guido;Miyamoto
• 通讯作者: Miyamoto

Periodic catastrophes over human evolutionary history are necessary to explain the forager population paradox.

人类进化史上周期性的灾难对于解释采集者种群悖论是必要的。

• 发表时间: 2019
• 影响因子: 11.1
• 作者: Gurven, Michael D;Davison, Raziel J
• 通讯作者: Davison, Raziel J

Multi-system physiological dysregulation and ageing in a subsistence population.

生存人口的多系统生理失调和老龄化。

• 发表时间: 2020-11-09
• 作者: Kraft, Thomas S;Stieglitz, Jonathan;Trumble, Benjamin C;Garcia, Angela R;Kaplan, Hillard;Gurven, Michael
• 通讯作者: Gurven, Michael