Biomechanical indicators of bicuspid aortic valve dysfunction

二尖瓣主动脉瓣功能障碍的生物力学指标

基本信息

批准号：
10202702
负责人：
Robert C Gorman
金额：
$ 71.61万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10202702
关键词：
3-Dimensional Affect Age Age-Years Aged, 80 and over Anatomy Aortic Aneurysm Aortic Valve Insufficiency Aortic Valve Stenosis Behavior Biomechanics Cardiac Characteristics Clinical Computer Models Computer software Congenital Heart Defects Consumption Data Databases Development Disease Dissection Echocardiography Functional disorder Future Geometry Goals Human Human Characteristics Life Liquid substance Maps Measures Mediating Methods Modeling Operative Surgical Procedures Organ Pathologic Pathology Patient risk Patients Pattern Phenotype Population Prevalence Property Risk Factors Role Shapes Statistical Data Interpretation Stress Structure Surface Time Tissues aortic valve aortic valve disorder aortic valve replacement base bicuspid aortic valve calcification clinical development clinical imaging clinically relevant hemodynamics high risk in vivo indexing male mechanical behavior mechanical properties novel physical property population based premature prevent reconstruction risk stratification screening shear stress virtual

项目摘要

Summary: The bicuspid aortic valve (BAV) is the most common cardiac congenital anomaly and affects ~1.4% of the population, with an approximate 2:1 male predominance. Due to the widespread availability and routine use of screening echocardiography, the identification of asymptomatic young patients with BAV has become increasingly common. It has been estimated that 30%-50% of BAV patients will require surgical intervention at some point in their life (1). Surgery is most commonly required for calcific aortic valve disease (CAVD) that results in symptomatic aortic stenosis (AS); less commonly required for aortic insufficiency (AI), ascending aortic aneurysm, and dissection. In aortic valve replacement (AVR) patients under 50 years old having AS, virtually all of them have BAV. In fact, until the age of 70 BAV patients outnumber those with tricuspid aortic valve (TAV) having AVR for AS. Between 71-80 years of age BAV and TAV occur in approximately equal numbers in symptomatic AS patients, and not until over the age of 80 do TAV patients predominate (2). While multiple factors are likely involved in the prevalence of AS in BAV patients and its relation to aortic dissection, the presence of a BAV is consistently an exceptionally strong risk factor for premature AS. Yet, in spite of this strong clinical association it is not currently possible to assess which patients with BAV are at highest risk for developing AS, preventing a rational basis for BAV patient risk stratification. We thus hypothesize that sensitive, clinically derivable functional indices can be obtained from patient-specific dynamic BAV anatomy that, when combined with population-based leaflet properties, will yield clinically relevant patient-specific strategies for identifying BAV patients at high risk for developing symptomatic AS in the future. Narrative: The bicuspid aortic valve (BAV) is the most common cardiac congenital anomaly. Due to the widespread availability and routine use of screening echocardiography, development of clinical methods for the identification of asymptomatic young patients with BAV is now realistic. We thus plan to develop sensitive, clinically derivable functional indices that will yield clinically relevant patient- specific strategies for identifying BAV patients at high risk.

摘要：二叶式主动脉瓣（BAV）是最常见的先天性心脏瓣膜疾病。异常现象，影响约 1.4% 的人口，其中男性比例约为 2:1 优势。由于筛查的广泛可用性和常规使用超声心动图，无症状年轻 BAV 患者的识别变得越来越普遍。据估计，30%-50%的BAV患者会在生命中的某个时刻需要进行手术干预 (1)。手术是最常见的钙化性主动脉瓣疾病（CAVD）所需的，导致有症状的主动脉瓣狭窄（AS）；主动脉瓣关闭不全 (AI)、升主动脉瓣关闭不全时不太需要动脉瘤和夹层。 50 岁以下的主动脉瓣置换术 (AVR) 患者老年人患有 AS，几乎所有人都患有 BAV。事实上，直到70岁BAV患者超过接受 AVR 治疗 AS 的三尖瓣主动脉瓣 (TAV) 患者。 71-80 之间有症状的 AS 中 BAV 和 TAV 的发生率大致相等 TAV 患者直到 80 岁以上才占主导地位 (2)。尽管 BAV 患者 AS 的患病率可能与多种因素有关与主动脉夹层相关，BAV 的存在始终是一种异常情况过早 AS 的强烈危险因素。然而，尽管有这种强烈的临床关联，目前无法评估哪些 BAV 患者的风险最高发展为 AS，阻碍了 BAV 患者风险分层的合理基础。我们因此假设敏感的、临床上可推导的功能指数可以从患者特定的动态 BAV 解剖学，当与基于人群的结合时传单特性，将产生临床相关的患者特异性策略来识别 BAV 患者未来出现症状性 AS 的风险很高。叙述：二叶式主动脉瓣 (BAV) 是最常见的心脏先天性瓣膜异常。由于筛查的广泛可用性和常规使用超声心动图，诊断临床方法的发展无症状年轻 BAV 患者现在已成为现实。因此我们计划开发敏感的、临床上可推导的功能指数将产生临床相关的患者- 识别高风险 BAV 患者的具体策略。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Computational methods for the aortic heart valve and its replacements.

主动脉心脏瓣膜及其替代物的计算方法。

DOI：
发表时间：
2017-11
期刊：
影响因子：
0
作者：
Zakerzadeh, Rana;Hsu, Ming;Sacks, Michael S
通讯作者：
Sacks, Michael S

Neural Network Approaches for Soft Biological Tissue and Organ Simulations.

用于软生物组织和器官模拟的神经网络方法。

DOI：
发表时间：
2022-12-01
期刊：
影响因子：
0
作者：
Sacks, Michael S;Motiwale, Shruti;Goodbrake, Christian;Zhang, Wenbo
通讯作者：
Zhang, Wenbo

Functional mechanical behavior of the murine pulmonary heart valve.

小鼠肺心瓣膜的功能机械行为。

DOI：
发表时间：
2023-08-08
期刊：
影响因子：
4.6
作者：
Feng, Xinzeng;Liu, Yifei;Kamensky, David;McComb, David W;Breuer, Christopher K;Sacks, Michael S
通讯作者：
Sacks, Michael S

FM-Track: A fiducial marker tracking software for studying cell mechanics in a three-dimensional environment.

FM-Track：一种基准标记跟踪软件，用于在三维环境中研究细胞力学。

DOI：
发表时间：
2020
期刊：
影响因子：
3.4
作者：
Lejeune, Emma;Khang, Ale;Sansom, Jacob;Sacks, Michael S
通讯作者：
Sacks, Michael S

A Deep Learning Framework for Design and Analysis of Surgical Bioprosthetic Heart Valves.

用于设计和分析外科生物人工心脏瓣膜的深度学习框架。

DOI：
发表时间：
2019-12-06
期刊：
影响因子：
4.6
作者：
Balu, Aditya;Nallagonda, Sahiti;Xu, Fei;Krishnamurthy, Adarsh;Hsu, Ming;Sarkar, Soumik
通讯作者：
Sarkar, Soumik

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Robert C Gorman其他文献

Patient-Specific Quantitative In-Vivo Assessment of Human Mitral Valve Leaflet Strain Before and After MitraClip Repair

MitraClip 修复前后人二尖瓣小叶应变的患者特异性定量体内评估

DOI：
发表时间：
2023
期刊：
Cardiovascular Engineering and Technology
影响因子：
1.8
作者：
Natalie T. Simonian;Hao Liu;Sneha Vakamudi;M. Pirwitz;A. Pouch;J. Gorman;Robert C Gorman;Michael S. Sacks
通讯作者：
Michael S. Sacks