Auditory experience during the prenatal and perinatal period

产前和围产期的听觉体验

基本信息

批准号：
10197097
负责人：
Brian Bruce Monson
金额：
$ 15.44万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197097
关键词：
Abdomen Acoustics Address Affect Age Age-Months Air Animals Attentional deficit Audiology Auditory Auditory Brainstem Responses Biological Birth Brain Brain Stem Caring Central Auditory Processing Disorder Child Childhood Cognition Disorders Communication Data Development Devices Diagnosis Diagnostic Early Intervention Environment Exhibits Exposure to Fetal Development Fetus Foundations Goals Healthcare Hearing High Prevalence Human Impaired cognition Incubators Infant Infant Incubators Language Language Development Language Disorders Learning Length of Stay Liquid substance Longitudinal Studies Measures Mechanics Medical Medicine Morbidity - disease rate Mothers National Institute on Deafness and Other Communication Disorders Neonatal Intensive Care Units Neurodevelopmental Disorder Neurosciences Newborn Infant Noise Outcome Pathology Pattern Perinatal Population Positioning Attribute Pregnant Women Premature Birth Premature Infant Reporting Research Risk Sensorineural Hearing Loss Solid Speech Survival Rate Survivors Testing Therapeutic Intervention Time Underserved Population United States Uterus Voice auditory neuropathy auditory pathway auditory processing circadian cohort communication behavior critical period effective intervention effective therapy experience exposed human population follow-up improved improved outcome in utero infancy insight intrauterine environment language processing neurodevelopment perinatal brain perinatal period personalized approach prenatal prospective recruit sound stem therapy design transmission process

项目摘要

Within the United States alone, over a half-million infants are born premature each year. While medical advances have dramatically improved survival rates, long-term morbidities related to auditory function are common. The preterm population suffers from a relatively high prevalence of sensorineural hearing loss, auditory neuropathy/dys-synchrony, and central auditory processing disorder. Even preterm infants in whom no specific auditory pathology has been diagnosed exhibit cognitive impairments related to auditory processing, including auditory attention deficits, language processing deficits, and other speech/language communication deficits. Despite these facts, a solid understanding of the impact of premature birth on auditory neurodevelopment is lacking. Possible effects of the acoustic environment are unknown. The long-term objective of this research is to characterize the effect of premature birth on auditory neurodevelopment and communication behavior to aid in improving best medical practices and therapeutic interventions for preterm infants. In this study, we propose to measure the effects of auditory input during the preterm period on neurodevelopmental outcomes. There are three specific aims. In Aim 1 we will recruit a cohort of preterm infants in the neonatal intensive care unit (NICU) to prospectively measure their auditory input during hospital stay. We will quantify detailed auditory experience in the NICU and determine how this differs from intrauterine auditory experience. In Aim 2 we will determine the effect of premature birth on auditory function at 3 months of age. In Aim 3 we will determine the relationship between our measured parameters of perinatal auditory experience and auditory function in infancy. The proposed study will lay the foundation for a longitudinal study aimed to determine the effect of auditory experience in the NICU on long-term auditory and language development. Valuable insight will be gained as to how premature birth and NICU environment might affect auditory neurodevelopment. Results of these studies will ultimately aid in identifying (1) effective interventions to optimize NICU auditory experience and (2) potential early-intervention therapies for NICU infants at greatest risk for auditory and language deficits later in childhood.

仅在美国，每年就有超过 50 万婴儿早产。就医的同时进步极大地提高了生存率，与听觉功能相关的长期发病率常见的。早产儿人群感音神经性听力损失的患病率相对较高，听觉神经病/不同步和中枢听觉处理障碍。即使是早产儿，特定的听觉病理学已被诊断出表现出与听觉处理相关的认知障碍，包括听觉注意力缺陷、语言处理缺陷和其他言语/语言交流赤字。尽管有这些事实，但对早产对听力的影响有深入的了解神经发育缺乏。声学环境可能产生的影响尚不清楚。长期来看本研究的目的是表征早产对听觉神经发育和发育的影响沟通行为有助于改善早产儿的最佳医疗实践和治疗干预措施婴儿。在这项研究中，我们建议测量早产期听觉输入对神经发育结果。具体目标有三个。在目标 1 中，我们将招募一组早产儿新生儿重症监护病房 (NICU) 中的婴儿在住院期间前瞻性测量他们的听觉输入停留。我们将量化新生儿重症监护病房 (NICU) 中的详细听觉体验，并确定这与宫内胎儿有何不同听觉体验。在目标 2 中，我们将确定早产对出生 3 个月时听觉功能的影响。年龄。在目标 3 中，我们将确定测量的围产期听觉参数之间的关系婴儿期的经验和听觉功能。拟议的研究将为纵向研究奠定基础旨在确定 NICU 中的听觉体验对长期听觉和语言的影响发展。将获得关于早产和 NICU 环境可能如何影响的宝贵见解听觉神经发育。这些研究的结果最终将有助于确定（1）有效的干预措施优化 NICU 听觉体验以及 (2) 最大程度地为 NICU 婴儿提供潜在的早期干预治疗儿童后期出现听觉和语言缺陷的风险。